Results 131 to 140 of about 43,097 (243)

Quantifying intracellular mechanosensitive response upon spatially defined mechano-chemical triggering. [PDF]

Elife
Zare-Eelanjegh E, Lewis RTM, Lüchtefeld I, Kutay U, Zambelli T.   +4 more
europepmc   +1 more source

Exosomal TGM2 From Hypoxia‐Primed Olfactory Mucosa MSCs Attenuates Senescent Astrocytes via NRF1/TFAM Signaling in Parkinson's Disease

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Hypoxia‐preconditioned olfactory mucosa mesenchymal stem cells (OM‐MSCs) release exosomes enriched with transglutaminase 2 (TGM2), which are taken up by astrocytes. Inside the nucleus, TGM2 activates NRF1, leading to the upregulation of TFAM. This enhances mitochondrial function by reducing mitochondrial DNA (mtDNA) leakage and improving mitochondrial ...
Xiqi Hu, Yuchang Liang, Hong Fan, Wenqi Fan, Zijie Wang, Ya‐nan Ma, Peipei Song, Ying Xia   +7 more
wiley   +1 more source

Dysregulated nuclear Lamin B1 in DYT1 dystonia thickens nuclear lamina and disrupts 14-3-3 proteins. [PDF]

Cell Death Discov
Duan Y, Sepehrimanesh M, Hosain MA, Cui H, Stagray J, Shen X, Xiao Y, Li Y, Zhang CL, Ding B.   +9 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Alleviates Metabolic Dysfunction‐Associated Fatty Liver Disease via AHR/AMPK Signaling Activation

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
IPA promotes AHR nuclear translocation and AMPK phosphorylation. Phosphorylated AMPK may in turn facilitate AHR translocation, suggesting a potential reciprocal interplay that contributes to alleviating hepatic lipid deposition in MAFLD. ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a health problem worthy of attention ...
Yanting Huang, Meimei Yu, Jiaxin Lu, Chujun Lin, Shuhuan Li, Yalin Chen, Xin Chen, Hongliang Xue, Jing Chen, Lijie Su   +9 more
wiley   +1 more source

Nuclear Lamins: A Molecular Bridge Coupling Extracellular Mechanical Cues to Intranuclear Signal Transduction and Gene Regulation. [PDF]

Int J Mol Sci
Yang S, Liu H, Kou H, Lai L, Zhang X, Xu Y, Sun Y, Chen B.   +7 more
europepmc   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Genetically reprogrammed BMSCs with Lamin B1 depletion enhance bone regeneration for osteoporosis therapy. [PDF]

Front Bioeng Biotechnol
Fu X, Huo S, Cao C, Hsu H, Huang J, Lei Y, Li J, Liu P, Zeng J, Lin S, Liang C.   +10 more
europepmc   +1 more source

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho, Min‐Kyung Choi, Mi‐Ock Baek, Hyeon‐Hee Son, Binh Thanh Nguyen, Min‐Jung Kang, Il‐Chan Kim, Jin‐Hyoung Kim, Mee‐Sup Yoon   +8 more
wiley   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Tau oligomerization induces nuclear lamina invagination and chromatin remodeling in Alzheimer's disease. [PDF]

Acta Neuropathol
Yuan S, Essepian N, Roberts R, Sherman E, Wang Q, Erisir A, Jiang L.   +6 more
europepmc   +1 more source