Aging Cell, Volume 25, Issue 8, August 2026.We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre +18 more
wiley +1 more source
Prelamin A in an <i>Lmna</i> <sup>L648R/L648R</sup> Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss. [PDF]
Arterioscler Thromb Vasc BiolWang Y +6 more
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Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice
Aging Cell, Volume 25, Issue 8, August 2026.Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez +11 more
wiley +1 more source
Characterizing the SASP‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types
Aging Cell, Volume 25, Issue 8, August 2026.In this paper, we characterized the brain cell‐type‐specific SASP and defined the directionality of a paracrine spreading of senescence phenotypes. We unraveled ligand‐receptor pairs underlying this spreading and showed that inhibiting this interaction ameliorates senescence dissemination.
Taylor Russo, Markus Riessland
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Detection of nuclear STING in cultured human cells and in the normal and cancer tissues. [PDF]
iScienceVo N, Chen E, Sidorova JM.
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The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis
British Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan +17 more
wiley +1 more source
Lamin A/C as a Molecular Link Between Nuclear Organization, Chromatin Dynamics, and Tumor Progression. [PDF]
CellsFoglini C, Scotlandi K, Pasello M.
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Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma +5 more
wiley +1 more source
SUV family histone methyltransferases correlate with nuclear lamina remodeling and clinical outcome in cancer: integrative pan-cancer TCGA analysis and experimental evidence. [PDF]
Sci RepKundu S, Akhtar AR, Kumar A, Sharma A.
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Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, Volume 59, Issue 8, August 2026.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source