Results 121 to 130 of about 54,589 (273)
Phytotherapy Research, EarlyView.Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang +9 more
wiley +1 more source
CellsTriple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterised by the absence of targetable hormone receptors and increased metastatic rates.
Emily Jessop +5 more
doaj +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Diabetic osteoporosis (DOP) is characterized by chronic low‐grade inflammation and impaired bone formation. Pinoresinol diglucoside (PDG), a bioactive compound derived from Eucommia ulmoides Oliv., has shown therapeutic potential in metabolic bone disorders; however, its direct molecular targets and integrated mechanisms remain unclear.
Wenqi Jin +7 more
wiley +1 more source
The role of A-Type lamins and LAP2a in cellular ageing of human fibroblasts in vitro [PDF]
, 2005 Mutations in LMNA gene have been linked to a number of age-related tissue-specific diseases and premature ageing syndromes termed laminopathies. The finding that A- type lamins affect longevity and maintenance of a number of somatic tissues makes them ...
PekovicÌ, Vanja, Peković, Vanja
core
Ajugol Improves Liver Fibrosis by Modulating Bile Acid and Arachidonic Acid Metabolism in Mice
Phytotherapy Research, EarlyView.Ajujol ameliorates hepatic fibrosis by regulating bile acid metabolism and suppressing inflammatory responses. ABSTRACT Ajugol (AJ), the primary component extracted from the root of Rehmannia glutinosa, exhibits protective effects against metabolic dysregulation and chronic inflammation.
Xia Wei +9 more
wiley +1 more source
Phytotherapy Research, EarlyView.Butein attenuates pathological cardiac hypertrophy by activating Nrf2–Sirt3 signaling, restoring mitochondrial function and redox homeostasis. ABSTRACT Butein (3,4,2′,4′‐tetrahydroxychalcone) is a bioactive chalcone with antioxidant, anti‐inflammatory, and cytoprotective properties.
Tsendsuren Tungalag, Dong Kwon Yang
wiley +1 more source
Functional characterization of LINC complex protein assemblies and their role in laminopathies [PDF]
, 2013 LINC (Linker of nucleoskeleton and cytoskeleton) complexes connect the nucleoskeleton to the cytoskeleton by interactions among LINC complex proteins and their interactions to proteins in the nucleus and the cytosol.
Yang, Liu
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Does innovation success need advocacy? Stakeholder involvement in firm innovation
Strategic Management Journal, EarlyView.Abstract Research Summary Prior research documents that firms often collaborate with advocacy groups to mitigate stakeholder contention. Integrating stakeholder theory into a performance model of collaborative innovation, we propose an overlooked explanation for such collaborations: to enhance the adoption of firms' innovations.
Paolo Carioli +3 more
wiley +1 more source
The effects of overexpression of lamin a and two mutants associated with premature aging on stem cell differentiation and proliferation. [PDF]
, 2007 The nuclear lamina is composed of A and B-type lamins and performs a number of functions within the nucleus. Mutations within lamins give rise to a group of diseases called laminopathies including autosomal dominant Emery-Dreifuss muscular dystrophy and ...
Gibbs-Seymour, Ian
core
More Than a Birthmark? A Growing Pediatric Skin Lesion
JEADV Clinical Practice, EarlyView.
Shatha Ahmad Al Hajjaj +2 more
wiley +1 more source