Results 111 to 120 of about 54,589 (273)
iNew Medicine, EarlyView.ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang +13 more
wiley +1 more source
Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation
iNew Medicine, EarlyView.The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li +11 more
wiley +1 more source
The Transcriptomic and Genomic Analysis of Lamin A/C Expression in the Colon and in Colorectal Cancer [PDF]
, 2011 Lamins A and C, also known as A-type lamins, are type V nuclear intermediate filament proteins which form an interlacing meshwork of filaments subjacent to the inner nuclear membrane termed the nuclear lamina.
RAHMAN-CASANS, SYED,FIDA,UR +1 more
core
Mechanical memory in aging: From adaptive sensing to pathological entrenchment
Interdisciplinary Medicine, EarlyView.Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang +7 more
wiley +1 more source
Matrix stiffness induces midnolin-dependent lamin B1 degradation to control myoblast differentiation
EMBO ReportsCells decode mechanical cues to direct fate decisions through nuclear remodeling, yet nuclear adaptors to mechanical signals remain elusive. Here, we show that soft matrix suppresses myoblast differentiation and induces nuclear abnormality within 30 min,
Liping Guo +11 more
doaj +1 more source
The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes [PDF]
, 2011 The premature ageing syndromes Hutchison-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are rare genetic disorders that result in greatly accelerated ageing. RD is neonatal fatal, whereas children suffering from HGPS age approximately 8
MUTER, JOANNE,RUTH
core
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao +6 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Abnormal protein levels have been demonstrated to contribute to the progression of various diseases, including metabolic syndrome (MetS). Here, we speculated that the downregulation of BMI1 might lead to the failure of METTL3 degradation and contribute to METTL3 overexpression in MetS‐related liver injury.
Yun‐Jiang Chen +4 more
wiley +1 more source
Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri +2 more
wiley +1 more source
Phytotherapy Research, EarlyView.Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li +10 more
wiley +1 more source