Results 171 to 180 of about 52,713 (325)

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

Aging Cell, EarlyView.
In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang, Maria Jose Gacha‐Garay, Yu Wang, Scott D. Collum, Rene A. Girard, Hydia Puente, Seung‐Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J. Wagner, Hari KrishnaYalamanchili, Harry Karmouty‐Quintana, Zheng Chen, Tingting Mills   +14 more
wiley   +1 more source

EDITORIAL. NUCLEAR STRUCTURE AND THE LAMINS [PDF]

, 1996
Fred T. Bosman
openalex   +1 more source

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, EarlyView.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation

Cell Reports
Summary: LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are reversely ...
Yuan Shen, Liang-Liang Zheng, Cai-Yun Fang, Yao-Yao Xu, Chao Wang, Jin-Tao Li, Ming-Zhu Lei, Miao Yin, Hao-Jie Lu, Qun-Ying Lei, Jia Qu   +10 more
doaj  

Disruption of Nuclear Lamin Organization Alters the Distribution of Replication Factors and Inhibits DNA Synthesis [PDF]

, 1997
Timothy P. Spann, Robert D. Moir, Anne E. Goldman, Reimer Stick, Robert D. Goldman   +4 more
openalex   +1 more source

Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment

Aging Cell, EarlyView.
Local growth hormone (GH) is expressed and secreted by senescent cells in the aging human colon. GH triggers epithelial‐to‐mesenchymal transition and activates colon cell motility by regulating extracellular matrix proteins, inducing cytoskeleton rearrangement and altering cell motility protein phosphorylation.
Vera Chesnokova, Svetlana Zonis, Richard Ainsworth, Tugce Apaydin, Christian Wong Valencia, Elora C. Greiner, Robert Barrett, Arminja N. Kettenbach, Shlomo Melmed   +8 more
wiley   +1 more source

Dexrazoxane protects against doxorubicin‐induced cardiotoxicity in susceptible human living myocardial slices: A proof‐of‐concept study

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Experimental Approach Living myocardial slices (LMS) were obtained from explanted end‐stage heart failure ...
Jort S. A. van der Geest, Ilse R. Kelters, Bauke Arends, Willem B. van Ham, Ernest Diez Benavente, Thirza A. Lapré, Petra van der Kraak, Pim van der Harst, Arco J. Teske, Andreas Dendorfer, M. Mostafa Mokhles, Pieter A. Doevendans, Teun P. de Boer, Linda W. van Laake, Joost P. G. Sluijter, Vasco Sampaio‐Pinto   +15 more
wiley   +1 more source

Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes. [PDF]

J Neurochem
Astrocyte senescence contributes to brain aging and neurodegeneration, yet human‐relevant models remain scarce. We developed a doxorubicin‐based protocol that reliably induces senescence in murine and human astrocytes. Treated cells showed nuclear enlargement, reduced proliferation (BrdU), and increased markers of senescence (p21, β‐galactosidase), DNA
Marques M, Hayashide LS, Amorim P, Fernandes BM, Araujo APB, Messor DF, Leocadio VE, Pessoa B, Corrêa JBLP, Villablanca C, Vidal RL, González-Billault C, Matias I, Gomes FCA, Diniz LP.   +14 more
europepmc   +2 more sources

Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.

, 1994
Valerie L. Goss, Barbara A. Hocevar, Larry J. Thompson, Carl A. Stratton, David J. Burns, Alan P. Fields   +5 more
openalex   +1 more source

Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B) [PDF]

, 2000
Antoine Muchir
openalex   +1 more source