Results 181 to 190 of about 52,713 (325)

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source

Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C

, 1993
Fan Lin, Howard J. Worman
openalex   +1 more source

Essential Roles forCaenorhabditis elegansLamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes [PDF]

, 2000
Jun Liu, Tom Rolef Ben-Shahar, Dieter Riemer, Millet Treinin, P. Spann, Klaus Weber, Andrew Fire, Yosef Gruenbaum   +7 more
openalex   +1 more source

Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3‐Cytoskeleton‐Nucleoskeleton Axis in Mechanical Osteogenic Programming

Cell Proliferation, EarlyView.
Large segmental bone defects can result in non‐union of fractures and present a formidable challenge in clinical management. This study aims to investigate the role of mechanical stimulation in regulating osteogenic differentiation of stem cells via the mechanosensitive protein PDLIM5, thereby promoting bone regeneration and repair.
Yuchao Yang, Shutong Wu, Yining Wang, Jiajun Tang, Jiaxuan Liu, Jinyang Wang, Yunfeng Li, Asmat Ullah Khan, Muhammad Akram Khan, Wenqing Liu, Jinhui Zhu, Konghe Hu, Jingxing Dai, Jun Ouyang   +13 more
wiley   +1 more source

The in vitro DNA-binding properties of purified nuclear lamin proteins and vimentin.

, 1990
Robert L. Shoeman, Peter Traub
openalex   +1 more source

YKT6 Is Essential for Male Fertility by Promoting Meiosis Progression During Spermatogenesis of Mice

Cell Proliferation, EarlyView.
Specifically ablating Ykt6 in pre‐meiotic germ cells and meiotic spermatocytes leads to complete sterility and meiotic arrest in conditional knockout male mice. YTK6 is required for stabilising intercellular bridges between spermatocytes due to its key role in maintaining protein homeostasis and vesicular transport‐dependent functions in spermatocytes,
Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao, Yongzhi Cao, Hongbin Liu   +8 more
wiley   +1 more source

The accumulation of progerin underlies the loss of aortic smooth muscle cells in Hutchinson-Gilford progeria syndrome. [PDF]

Cell Death Dis
Kim PH, Kim JR, Heizer PJ, Jung H, Tu Y, Presnell A, Scheithauer J, Yu RG, Young SG, Fong LG.   +9 more
europepmc   +1 more source

C. elegansNuclear Envelope Proteins Emerin, MAN1, Lamin, and Nucleoporins Reveal Unique Timing of Nuclear Envelope Breakdown during Mitosis [PDF]

, 2000
KK Lee, Yosef Gruenbaum, P. Spann, Jun Liu, Katherine L. Wilson   +4 more
openalex   +1 more source

Left atrial remodeling in epilepsy: A comparative echocardiographic study of left atrial emptying fraction and left atrial volumetric index in patients with epilepsy

Epilepsia, EarlyView.
Abstract Objective Patients with epilepsy (PWE) are at increased risk for cardiac abnormalities, including arrhythmias, structural changes, and sudden unexpected death in epilepsy (SUDEP). Although previous studies have examined ventricular dysfunction, left atrial (LA) structural and mechanical changes remain underexplored.
Selcen Duran, Yalcin Boduroglu
wiley   +1 more source

Heterogeneity of Nuclear Lamin A Mutations in Dunnigan-Type Familial Partial Lipodystrophy* [PDF]

, 2000
Robert A. Hegele, Henian Cao, Carol M. Anderson, Irene Hramiak   +3 more
openalex   +1 more source