Results 171 to 180 of about 54,589 (273)

Muscular dystrophy-associated lamin variants disrupt cellular organization through a nucleolar-ribosomal axis. [PDF]

Sci Adv
Ding X, Kumari S, F Gregory E, Starr DA, Luxton GWG.   +4 more
europepmc   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Whole genome duplication through mitotic slippage causes nuclear instability. [PDF]

EMBO J
Gemble S, Budzyk M, Simon A, Lambuta R, Nanni L, Weiss N, Forest A, Miroshnikova Y, Scotto Di Carlo F, Marthiens V, Verdel C, Fang J, Desdouets C, Wickström SA, Ciriello G, Oricchio E, Almouzni G, Basto R.   +17 more
europepmc   +1 more source

Change‐of‐function fibroblast growth factor receptor 3 mutations causing skeletal dysplasias

Journal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
We show that the ligands FGF1 and FGF2 elicit differential fibroblast growth factor receptor 3 (FGFR3) signaling responses and that the FGFR3 G380R and A391E mutations reshape these signaling outputs. Thus, pathogenic FGFR3 mutations found in skeletal dysplasia do not simply enhance signaling strength and should be reclassified from “gain‐of‐function ...
Tanaya Roy, Zuzana Feketova, Jiawei Liu, Pavel Krejci, Kalina Hristova   +4 more
wiley   +1 more source

Alpinetin Protects Against High‐Fat Diet‐Induced Hepatic Injury via Mitigating Oxidative Stress, and Ferroptosis Through Modulating LXRα

Food Frontiers, Volume 7, Issue 6, November 2026.
Alpinetin protects against high‐fat diet‐ or palmitic acid‐induced nonalcoholic fatty liver disease by restoring LXR‐α expression. Activation of LXR‐α reduces hepatic lipid accumulation through suppression of lipogenic genes while alleviating oxidative stress and ferroptosis, ultimately improving liver function and attenuating hepatic injury.
Yanzi Yang, Tianhao Yu, Yujia Chu, Xingyu Liu, Qingping Lu, Tushuai Li, Jie Zhang   +6 more
wiley   +1 more source

The risk of nephrotic range proteinuria and kidney failure in primary laminopathies is genotype specific. [PDF]

JCI Insight
Sewerin S, Aurnhammer C, Hamed M, Revêchon G, Schönauer R, Findeisen C, Miehle K, Tesařo Vá Š, Georgomanolis T, Bergmann C, Wolff C, Kollár M, Akinci B, Araújo-Vilar D, Ceccarini G, Csajbók É, Gambineri A, Heni M, Scherer T, Štotl I, Sorkina E, Vantyghem MC, Vorona E, Wabitsch M, von Schnurbein J, Vatier C, Roume J, Reznik Y, Eriksson M, Antonin W, Vigouroux C, Halbritter J.   +31 more
europepmc   +1 more source

Quantitative Assessment of Mesoscale Cellular Order and Organization in the Mouse Hippocampus

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT The hippocampus is characterized by a stereotypical macroscopic structure, where the nuclei are densely and heterogeneously packed among different subregions of the hippocampus. Despite the fact that tissue‐specific cellular organization has been implicated in neural function, it has been technically challenging to quantitatively analyze ...
Konstantin Hein, Humberto Romero‐Limon, Conrad Möckel, Anne Karasinsky, Stephanie Möllmert, Jona Kayser, Alessio Zaccone, Jochen Guck, Tomohisa Toda   +8 more
wiley   +1 more source

Patching up the nucleus: a novel role for PMLII in nuclear envelope stability. [PDF]

Nucleic Acids Res
Janssen AFJ, Knowles O, Britton S, Kumita JR, Deane JE, Spruijt E, Larrieu D.   +6 more
europepmc   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

An Epi(c) Path to LMNA Cardiomyopathy. [PDF]

JACC Basic Transl Sci
Wang Y, Rau CD.
europepmc   +1 more source