Results 171 to 180 of about 82,088 (275)

Histone Density and Dynamics Shape Mitotic Chromatid Architecture in Xenopus Egg Extracts

Genes to Cells, Volume 31, Issue 3, May 2026.
Histone chaperones and chromatin remodelers modulate histone density and dynamics. The resulting local chromatin properties are integrated with DNA reconfiguration activities mediated by condensins and topoisomerase IIα to shape the global architecture of mitotic chromosomes.
Keishi Shintomi, Keita Ohsumi, Mari Iwabuchi, Tatsuya Hirano   +3 more
wiley   +1 more source

A Highly Conserved SNARE‐Associated Protein Enhances Plant Immunity by Regulating Vesicle Trafficking

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3426-3440, May 2026.
ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk, Peitong Li, Hafiz Muhammad Khalid Abbas, Mst Shamira Sultana, Sarbottam Piya, Nicole Coffey, Cengizhan Öztürk, Sobhan Bahrami Zadegan, Susan Thomas Laird, Mazen Alazem, Samantha P. Nuzzi, J. Hollis Rice, Chris Wyman, Tessa Burch‐Smith, Vince Pantalone, Tarek Hewezi   +15 more
wiley   +1 more source

MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer. [PDF]

Cell Commun Signal
Eguchi T, Taha EA, Nakano K, Tiwari V, Takebe K, Inoue T, Xing L, Sogawa C, Okamoto K, Calderwood SK.   +9 more
europepmc   +1 more source

Development of Styryl‐Modified 3,4‐Dihydropyrimidin‐2(1H)‐ones as Potential Antitumor Agents

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Styryl‐modified 3,4‐dihydropyrimidin‐2(1H)‐ones (DHPMs), designed from the Eg5 inhibitor monastrol, show markedly enhanced antiproliferative activity in HeLa and MCF‐7 cancer cells. Lead compounds 16 and 17 trigger apoptosis through cell‐line‐specific pathways and downregulate c‐Myc, emerging as promising anticancer candidates.
Konstantinos Panagoulias, Woonghee Kim, Murat Ozdemir, Busra Turan, Adil Mardinoglu, Hasan Turkez, Daniela Trisciuzzi, Orazio Nicolotti, Antonio Di Stefano, Stamatia Vassiliou, Ivana Cacciatore   +10 more
wiley   +1 more source

Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles. [PDF]

Aging Cell
Ma T, Bao H, Xu Z, Ren H, Tian W, Chen J, Liu Z, Lu X, Lv F, Yao Q, Qi Y, Huang K.   +11 more
europepmc   +1 more source

Paclitaxel compromises nuclear integrity in interphase through SUN2-mediated cytoskeletal coupling. [PDF]

J Cell Sci
Hale T, Hale VL, Kolata P, Dos Santos Á, Allegretti M.   +4 more
europepmc   +1 more source

Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity. [PDF]

J Cell Sci
Bunner S, Huang K, Shah A, Figueroa S, Lang N, Chu C, Eskndir N, Pho M, Manning G, Zheng M, Fritz-Laylin L, Velle KB, Marcus J, Orth J, Stephens AD.   +14 more
europepmc   +1 more source

Fertilization with Protamine-2 deficient sperm triggers abnormal pronucleus development and zygotic cleavage†. [PDF]

Biol Reprod
Rainsford SR, Tse K, Walters BW, Oh JN, Sumigray K, Lesch BJ, Smith ZD.   +6 more
europepmc   +1 more source

Phosphorylation-dependent modulation of the Lamin A/C-EZH2 complex regulates epithelial-mesenchymal plasticity. [PDF]

Nucleic Acids Res
Ak B, Saha S, Sengupta K.
europepmc   +1 more source

Cdk1-dependent lamin aggregation underlies oxidative stress-induced nuclear shape abnormalities. [PDF]

BMB Rep
Ahn JH, Cho MG, Basit A, Song IK, Lee KJ, Lee JH.   +5 more
europepmc   +1 more source