Results 51 to 60 of about 92,845 (317)
Structure and unique mechanical aspects of nuclear lamin filaments.
Current Opinion in Structural Biology, 2020 The major constituent of the nuclear envelope is the nuclear lamina. A fibrous meshwork of lamin filaments spanning underneath the nuclear membrane provides mechanical support to the nucleus.
Rafael Tenga, O. Medalia
semanticscholar +1 more source
Journal of Translational Medicine, 2023 Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan +12 more
doaj +1 more source
Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone
Cells, 2020 Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into nucleus.
Natividad Alcorta-Sevillano +3 more
semanticscholar +1 more source
PLoS ONE, 2012 Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla +5 more
doaj +1 more source
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis
EMBO Journal, 2020 Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation
T. Bedrosian +12 more
semanticscholar +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]
, 2013 The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core +1 more source
Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D. +23 more
core +2 more sources
Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]
, 2017 Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K. +4 more
core +2 more sources
Journal of Clinical Investigation, 2020 Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control.
Andrea Bianchi +17 more
semanticscholar +1 more source