Results 51 to 60 of about 96,178 (343)

Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone

Cells, 2020
Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into nucleus.
Natividad Alcorta-Sevillano, Iratxe Macías, C. I. Rodríguez, A. Infante   +3 more
semanticscholar   +1 more source

Influences of lamin A levels on induction of pluripotent stem cells

Biology Open, 2012
Summary Lamin A is an inner nuclear membrane protein that maintains nuclear structure integrity, is involved in transcription, DNA damage response and genomic stability, and also links to cell differentiation, senescence, premature aging and associated ...
Bingfeng Zuo, Jiao Yang, Fang Wang, Lei Wang, Yu Yin, Jiameng Dan, Na Liu, Lin Liu   +7 more
doaj   +1 more source

Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty

Frontiers in Cell and Developmental Biology, 2023
Clinical frailty affects ∼10% of people over age 65 and is studied in a chronically inflamed (Interleukin-10 knockout; “IL10-KO”) mouse model. Frailty phenotypes overlap the spectrum of diseases (“laminopathies”) caused by mutations in LMNA. LMNA encodes
Fatima D. Elzamzami, Arushi Samal, Adith S. Arun, Tejas Dharmaraj, Neeti R. Prasad, Alex Rendon-Jonguitud, Lauren DeVine, Jeremy D. Walston, Robert N. Cole, Katherine L. Wilson   +9 more
doaj   +1 more source

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila.

PLoS ONE, 2022
Epigenetic alterations occur during aging, but it remains unclear what epigenetic features are associated with the onset of physiological decline in animals.
Wei-Qi Lin, Zhen-Kai Ngian, Tong-Wey Koh, Chin-Tong Ong   +3 more
doaj   +1 more source

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

EMBO Journal, 2020
Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation
T. Bedrosian, J. Houtman, J. Eguiguren, Saeed Ghassemzadeh, N. Rund, Nicole Novaresi, Lauren Hu, Sarah L. Parylak, Ahmet M. Denli, Lynne Randolph-Moore, T. Namba, F. Gage, T. Toda   +12 more
semanticscholar   +1 more source

The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.

PLoS ONE, 2012
Lamins' functions are regulated by phosphorylation at specific sites but our understanding of the role of such modifications is practically limited to the function of cdc 2 (cdk1) kinase sites in depolymerization of the nuclear lamina during mitosis.
Magdalena Zaremba-Czogalla, Katarzyna Piekarowicz, Katarzyna Wachowicz, Katarzyna Kozioł, Magda Dubińska-Magiera, Ryszard Rzepecki   +5 more
doaj   +1 more source

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

Journal of Translational Medicine, 2023
Background Dilated cardiomyopathy (DCM) is a severe, non-ischemic heart disease which ultimately results in heart failure (HF). Decades of research on DCM have revealed diverse aetiologies.
Chia Yee Tan, Pui Shi Chan, Hansen Tan, Sung Wei Tan, Chang Jie Mick Lee, Jiong-Wei Wang, Shu Ye, Hendrikje Werner, Ying Jie Loh, Yin Loon Lee, Matthew Ackers-Johnson, Roger S. Y. Foo, Jianming Jiang   +12 more
doaj   +1 more source

Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy

Genetics in Medicine, 2020
Lamins are the major component of nuclear lamina, maintaining structural integrity of the nucleus. Lamin A/C variants are well established to cause a spectrum of disorders ranging from myopathies to progeria, termed laminopathies.
D. Parry, Carol-Anne Martin, P. Greene, J. Marsh, J. C. P. E. L. M. F. J. M. C. R. H. M. J. G. C. C. E. Ambrose Arumugam Baple Bleda Boardman-Pretty Boiss, J. Ambrose, P. Arumugam, E. Baple, M. Bleda, F. Boardman-Pretty, J. Boissiere, C. Boustred, H. Brittain, M. Caulfield, G. Chan, C. Craig, L. Daugherty, A. de Burca, A. Devereau, G. Elgar, R. E. Foulger, T. Fowler, P. Furió-Tarí, A. Giess, J. Hackett, D. Halai, A. Hamblin, S. Henderson, J. Holman, T. Hubbard, K. Ibáñez, R. Jackson, L. J. Jones, D. Kasperaviciute, M. Kayikci, A. Kousathanas, L. Lahnstein, K. Lawson, S. Leigh, I. Leong, F. J. Lopez, F. Maleady-Crowe, J. Mason, E. McDonagh, L. Moutsianas, M. Mueller, N. Murugaesu, A. Need, C. Odhams, A. Orioli, C. Patch, D. Perez-Gil, M. Pereira, D. Polychronopoulos, J. Pullinger, T. Rahim, A. Rendon, P. Riesgo-Ferreiro, T. Rogers, M. Ryten, K. Savage, K. Sawant, R. Scott, A. Siddiq, A. Sieghart, D. Smedley, K. Smith, S. Smith, A. Sosinsky, W. Spooner, H. E. Stevens, A. Stuckey, R. Sultana, M. Tanguy, E. Thomas, S. Thompson, C. Tregidgo, A. Tucci, E. Walsh, S. Watters, M. Welland, E. Williams, K. Witkowska, S. Wood, M. Zarowiecki, Moira Blyth, H. Cox, D. Donnelly, L. Greenhalgh, S. Greville-Heygate, V. Harrison, K. Lachlan, C. McKenna, A. Quigley, Gillian Rea, L. Robertson, M. Suri, A. Jackson   +97 more
semanticscholar   +1 more source

Sequences within the C terminus of the metabotropic glutamate receptor 5 (mGluR5) are responsible for inner nuclear membrane localization [PDF]

, 2017
Traditionally, G-protein-coupled receptors (GPCR) are thought to be located on the cell surface where they transmit extracellular signals to the cytoplasm.
Harmon, Steven K., Jong, Yuh-Jiin I., Kumar, Vikas, O\u27Malley, Karen L., Sergin, Ismail   +4 more
core   +2 more sources