Results 61 to 70 of about 92,845 (317)

Altered protein dynamics of disease-associated lamin A mutants

BMC Cell Biology, 2004
Background Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes.
Worman Howard J, Östlund Cecilia, Perry Paul, Gilbert Nick, Gilchrist Susan, Bickmore Wendy A   +5 more
doaj   +1 more source

Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers

Biomarker Research, 2018
Background In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypothesis was that the loss of nuclear
Callinice D Capo-chichi, Kathy Q Cai, Xiang-Xi Xu   +2 more
doaj   +1 more source

Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy

Genetics in Medicine, 2020
Lamins are the major component of nuclear lamina, maintaining structural integrity of the nucleus. Lamin A/C variants are well established to cause a spectrum of disorders ranging from myopathies to progeria, termed laminopathies.
D. Parry, Carol-Anne Martin, P. Greene, J. Marsh, J. C. P. E. L. M. F. J. M. C. R. H. M. J. G. C. C. E. Ambrose Arumugam Baple Bleda Boardman-Pretty Boiss, J. Ambrose, P. Arumugam, E. Baple, M. Bleda, F. Boardman-Pretty, J. Boissiere, C. Boustred, H. Brittain, M. Caulfield, G. Chan, C. Craig, L. Daugherty, A. de Burca, A. Devereau, G. Elgar, R. E. Foulger, T. Fowler, P. Furió-Tarí, A. Giess, J. Hackett, D. Halai, A. Hamblin, S. Henderson, J. Holman, T. Hubbard, K. Ibáñez, R. Jackson, L. J. Jones, D. Kasperaviciute, M. Kayikci, A. Kousathanas, L. Lahnstein, K. Lawson, S. Leigh, I. Leong, F. J. Lopez, F. Maleady-Crowe, J. Mason, E. McDonagh, L. Moutsianas, M. Mueller, N. Murugaesu, A. Need, C. Odhams, A. Orioli, C. Patch, D. Perez-Gil, M. Pereira, D. Polychronopoulos, J. Pullinger, T. Rahim, A. Rendon, P. Riesgo-Ferreiro, T. Rogers, M. Ryten, K. Savage, K. Sawant, R. Scott, A. Siddiq, A. Sieghart, D. Smedley, K. Smith, S. Smith, A. Sosinsky, W. Spooner, H. E. Stevens, A. Stuckey, R. Sultana, M. Tanguy, E. Thomas, S. Thompson, C. Tregidgo, A. Tucci, E. Walsh, S. Watters, M. Welland, E. Williams, K. Witkowska, S. Wood, M. Zarowiecki, Moira Blyth, H. Cox, D. Donnelly, L. Greenhalgh, S. Greville-Heygate, V. Harrison, K. Lachlan, C. McKenna, A. Quigley, Gillian Rea, L. Robertson, M. Suri, A. Jackson   +97 more
semanticscholar   +1 more source

Baculovirus infection induces disruption of the nuclear lamina

Scientific Reports, 2017
Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang, Kaiyan Xu, Denghui Wei, Wenbi Wu, Kai Yang, Meijin Yuan   +5 more
doaj   +1 more source

Leichtlösliche, lichtechte Perylen-Fluoreszenzfarbstoffe [PDF]

, 1988
Die Synthese von Perylenfarbstoffen 2 mit terminalen Alkylgruppen wird beschrieben. Langkettige n-Alkylgruppen führen nicht zu einer Erhöhung der Löslichkeit, sondern zu einer Erniedrigung.
Adkins, Aubert, Kitatsuji, Langhals, Langhals, Langhals, Langhals, Niobe, Pohland, Prelog, Rademacher, Rohrmann, Sadrai, Černý   +13 more
core   +1 more source

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

Frontiers in Cell and Developmental Biology, 2019
We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response.
Elisabetta Mattioli, Elisabetta Mattioli, Davide Andrenacci, Davide Andrenacci, Antonello Mai, Sergio Valente, Joke Robijns, Winnok H. De Vos, Cristina Capanni, Cristina Capanni, Giovanna Lattanzi, Giovanna Lattanzi   +11 more
doaj   +1 more source

Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. [PDF]

PLoS ONE, 2014
Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus.
Jose M González-Granado, Ana Navarro-Puche, Pedro Molina-Sanchez, Marta Blanco-Berrocal, Rosa Viana, Jaime Font de Mora, Vicente Andrés   +6 more
doaj   +1 more source

Strange Laminates

Mathematical Methods in the Applied Sciences, 2012
Laminates made of composite anisotropic layers have a large varieties of different possible elastic responses. Still remaining in the classical field of linear elasticity, it is possible to obtain, with laminates, elastic behaviors that are very strange and completely unusual not only for classical materials, like metallic alloys, but also for the same
openaire   +3 more sources

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Nature Communications, 2019
Mutations in LMNA, which encodes the nuclear proteins Lamin A/C, can cause cardiomyopathy and conduction disorders. Here, we employ induced pluripotent stem cells (iPSCs) generated from human cells carrying heterozygous K219T mutation on LMNA to develop ...

semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source