Results 61 to 70 of about 53,083 (269)

Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

EMBO Journal, 2020
Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation
T. Bedrosian, J. Houtman, J. Eguiguren, Saeed Ghassemzadeh, N. Rund, Nicole Novaresi, Lauren Hu, Sarah L Parylak, Ahmet M. Denli, Lynne Randolph-Moore, T. Namba, F. Gage, T. Toda   +12 more
semanticscholar   +1 more source

Nuclear Lamins [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Thomas, Dechat, Stephen A, Adam, Pekka, Taimen, Takeshi, Shimi, Robert D, Goldman   +4 more
openaire   +2 more sources

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.

PLoS ONE, 2017
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi, Diane Frankel, Julien Guinde, Sophie Perrin, Sophie Laroumagne, Andrée Robaglia-Schlupp, Kevin Ostacolo, Karim Harhouri, Rachid Tazi-Mezalek, Joelle Micallef, Hervé Dutau, Pascale Tomasini, Annachiara De Sandre-Giovannoli, Nicolas Lévy, Pierre Cau, Philippe Astoul, Patrice Roll   +16 more
doaj   +1 more source

Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. [PDF]

PLoS ONE, 2014
Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus.
Jose M González-Granado, Ana Navarro-Puche, Pedro Molina-Sanchez, Marta Blanco-Berrocal, Rosa Viana, Jaime Font de Mora, Vicente Andrés   +6 more
doaj   +1 more source

Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer’s Disease Progression

International Journal of Molecular Sciences, 2020
Background. Recent reports point to a nuclear origin of Alzheimer’s disease (AD). Aged postmitotic neurons try to repair their damaged DNA by entering the cell cycle.
Laura Gil, S. Niño, É. Chi-Ahumada, Ildefonso Rodríguez-Leyva, C. Guerrero, Ana B Rebolledo, J. Arias, M. Jiménez-Capdeville   +7 more
semanticscholar   +1 more source

Baculovirus infection induces disruption of the nuclear lamina

Scientific Reports, 2017
Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang, Kaiyan Xu, Denghui Wei, Wenbi Wu, Kai Yang, Meijin Yuan   +5 more
doaj   +1 more source

Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers

Biomarker Research, 2018
Background In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypothesis was that the loss of nuclear
Callinice D Capo-chichi, Kathy Q Cai, Xiang-Xi Xu   +2 more
doaj   +1 more source

Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice

Nucleus, 2023
The Lmna knockout mouse (Lmna–/–) created by Sullivan and coworkers in 1999 has been widely used to examine lamin A/C function. The knockout allele contains a deletion of Lmna intron 7–exon 11 sequences and was reported to be a null allele.
Joonyoung R. Kim, Paul H. Kim, Ashley Presnell, Yiping Tu, Stephen G. Young   +4 more
doaj   +1 more source

An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Deficiencies in lamin B1 or lamin B2 in mice result in markedly reduced neuronal density in the cerebral cortex, but the mechanism has been unclear.
Natalie Y. Chen, Ye Yang, Thomas A. Weston, Jason N. Belling, Patrick J. Heizer, Yiping Tu, Paul H. Kim, Lovelyn Edillo, S. Jonas, P. Weiss, L. Fong, S. Young   +11 more
semanticscholar   +1 more source

Laminate Veneerler

Selcuk Dental Journal, 2022
Laminate Veneerler Estetik dental tedavilerde hastaların beklenti ve gereksinimleri günden güne artmaktadır. Dental estetik, hastaların kaybettikleri estetik görüntünün yeniden kazandırılmasında son derece önemli bir yer tutmaktadır. Hasta beklentilerinin bu denli yüksek olması, hekimleri tedavilerde daha estetik materyaller kullanmaya ve daha ...
Emre SİVA, Hakan TERZİOGLU
openaire   +3 more sources