Results 121 to 130 of about 41,627 (225)
Neuropathology, Volume 46, Issue 2, April 2026.ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya +5 more
wiley +1 more source
Starch Synthase 3 isoforms are essential for normal starch granule initiation in wheat endosperm
New Phytologist, Volume 250, Issue 2, Page 1075-1091, April 2026.Summary Wheat grains have two distinct types of starch granules. Large, lenticular A‐type granules are formed from a single initiation per amyloplast during early grain development, while numerous small B‐type granules are initiated during later grain development.
Jinjin Ding +4 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So +7 more
wiley +1 more source
Lamins' role in osteosarcoma. [PDF]
Front Cell Dev BiolBagnato G, Peruzzi B.
europepmc +1 more source
Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer
International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley +1 more source
Baculoviruses exploit the mitotic kinase CDK1 to disrupt the nuclear lamina. [PDF]
PLoS PathogMo M +5 more
europepmc +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, Volume 20, Issue 3, Page 727-752, March 2026.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting
Advanced Materials, Volume 38, Issue 16, 17 March 2026.A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang +8 more
wiley +1 more source
Attenuated lamin A-prohibitin2 interaction leads to mitochondrial dysfunction in LMNA 289 A>G-mediated dilated cardiomyopathy. [PDF]
J Biol ChemNath S +4 more
europepmc +1 more source
Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis
Advanced Materials, Volume 38, Issue 15, 12 March 2026.This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar +5 more
wiley +1 more source