Results 141 to 150 of about 21,188,703 (341)

Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

iScience
Summary: Lamins A and C are components of the lamina at the nuclear periphery and associate with heterochromatin. A distinct, relatively mobile pool of lamin A/C in the nuclear interior associates with euchromatic regions and with lamin-associated ...
Daria Filipczak, Anna Souchet, Konstantina Georgiou, Roland Foisner, Nana Naetar   +4 more
doaj   +1 more source

OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A

Cells, 2018
The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases (‘laminopathies’). Lamins A and C are identical for their first 566 residues.
Dan N. Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B. Peterson, Yosef Gruenbaum, Cathrine R. Carlson, Line M. Grønning-Wang, Donald F. Hunt, Katherine L. Wilson   +11 more
doaj   +1 more source

Smurf2 regulates stability and the autophagic–lysosomal turnover of lamin A and its disease‐associated form progerin

Aging Cell, 2018
A‐lamins, encoded by the LMNA gene, are major structural components of the nuclear lamina coordinating essential cellular processes. Mutations in the LMNA gene and/or alterations in its expression levels have been linked to a distinct subset of human ...
A. P. Borroni, Andrea Emanuelli, P. Shah, Nataša Ilić, L. Apel-Sarid, B. Paolini, Dhanoop Manikoth Ayyathan, Praveen Koganti, Gal Levy-Cohen, M. Blank   +9 more
semanticscholar   +1 more source

Journal of African Christian Biography: v. 2, no. 3 [PDF]

, 2017
A publication of the Dictionary of African Christian Biography with U.S. offices located at the Center for Global Christianity and Mission at Boston University. This issue focuses on: 1. Agnes Okoh. 2. Self-Sacrificial Christian Pioneers of Uganda.
Bonk, Jonathan J., Byaruhanga, Christopher, Kalengyo, Edison Muhindo, Oduro, Thomas, Tumwine, John Kateeba, Way, Yossa   +5 more
core  

Supplementary Figures from Lamin B1 Is a Novel Therapeutic Target of Betulinic Acid in Pancreatic Cancer

, 2023
Lei Li, Yiqi Du, Xiangyu Kong, Zhaoshen Li, Zhiliang Jia, Jiujie Cui, Jun Gao, Guokun Wang, Keping Xie   +8 more
openalex   +1 more source

Lamin complexes in the nuclear interior control progenitor cell proliferation and tissue homeostasis [PDF]

, 2009
Nana Naetar, Roland Foisner
openalex   +1 more source

Binding of lamin A to polynucleosomes

Journal of Biological Chemistry, 1991
Morphological observations suggest a close association between heterochromatin and the nuclear lamina. To investigate the molecular aspects of this association, we have established a simple sedimentation assay employing purified lamin proteins, or their 125I-labeled derivatives, and polynucleosomal particles isolated from avian erythrocytes.
Yuan, J., Simos, G., Blobel, G., Georgatos, S. D.   +3 more
openaire   +3 more sources

Lamin A/C and PI(4,5)P2—A Novel Complex in the Cell Nucleus

Cells
Lamins, the nuclear intermediate filaments, are important regulators of nuclear structural integrity as well as nuclear functional processes such as DNA transcription, replication and repair, and epigenetic regulations.
Sara Escudeiro-Lopes, Vlada V. Filimonenko, Lenka Jarolimová, Pavel Hozák   +3 more
doaj   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation

Nature Communications
Alterations in nuclear structure and function are hallmarks of cancer cells. Little is known about these changes in Cancer-Associated Fibroblasts (CAFs), crucial components of the tumor microenvironment. Loss of the androgen receptor (AR) in human dermal
Soumitra Ghosh, Jovan Isma, Paola Ostano, Luigi Mazzeo, Annagiada Toniolo, Monalisa Das, Joni R. White, Christian Simon, G. Paolo Dotto   +8 more
doaj   +1 more source