Results 151 to 160 of about 21,188,703 (341)

Lamin A mutation impairs interaction with nucleoporin NUP155 and disrupts nucleocytoplasmic transport in atrial fibrillation

open access: yesHuman Mutation, 2018
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Here, we show the identification and functional characterization of one AF‐associated mutation p.Arg399Cys in lamin A/C.
Meng Han   +13 more
semanticscholar   +1 more source

Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]

open access: yes, 2011
The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core  

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

open access: yesCytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos   +5 more
wiley   +1 more source

152: Development of DNA damage foci, loss of Lamin B and activation of pp38MAPK in pPROM: classic signs of senescence in human amniochorion [PDF]

open access: bronze, 2014
Eryn Dutta   +5 more
openalex   +1 more source

Lamin A/C, laminopathies and premature ageing.

open access: yesHistology and histopathology, 2008
Lamin A/C belongs to type V intermediate filaments and constitutes the nuclear lamina and nuclear matrix, where a variety of nuclear activities occur. Lamin A/C protein is firstly synthesized as a precursor and is further proteolytically processed by the zinc metallo-proteinase Ste24 (Zmpste24).
Zhou, Z, Liu, B
openaire   +4 more sources

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells

open access: yesThe Nucleus, 2018
Interphase phosphorylation of lamin-A,C depends dynamically on a cell's microenvironment, including the stiffness of extracellular matrix. However, phosphorylation dynamics is poorly understood for diseased forms such as progerin, a permanently ...
Sangkyun Cho   +6 more
semanticscholar   +1 more source

The effects of environmental and classroom noise on the academic attainments of primary school children [PDF]

open access: yes, 2008
While at school children are exposed to various types of noise including external, environmental noise and noise generated within the classroom. Previous research has shown that noise has detrimental effects upon children?s performance at school ...
Dockrell, Julie, Shield, Bridget
core   +1 more source

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

open access: yesFood Frontiers, EarlyView.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu   +8 more
wiley   +1 more source

Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry [PDF]

open access: hybrid, 2011
Veronika Butin‐Israeli   +6 more
openalex   +1 more source

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