Results 151 to 160 of about 1,866,196 (278)

Nuclear-lamin-guided plastic positioning and folding of the human genome

Cell Reports
Summary: The human genome exhibits a highly ordered hierarchical architecture, yet the mechanisms governing its large-scale organization remain poorly understood.
Zehua Wang, Qianzhao Ji, Zunpeng Liu, Chunyu Jiao, Yiyuan Zhang, Feifei Liu, Shuhui Sun, Qun Chu, Zeming Wu, Jingyi Li, Hao Li, Jianli Hu, Yizhou Gao, Gang Cao, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Guang-Hui Liu, Jing Qu   +17 more
doaj   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Unveiling Propriety, Validity and Consensus: A Multi‐level Examination of Legitimacy Following the Global Financial Crisis

Journal of Management Studies, EarlyView.
Abstract Previous work on legitimacy has conceptualized its multi‐level nature, encompassing individual‐level propriety and collective‐level validity. Recently, scholars have introduced the construct of consensus, the degree to which evaluators agree in terms of their propriety beliefs.
Patrick Haack, Jost Sieweke, Michael D. Pfarrer   +2 more
wiley   +1 more source

Expression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutation

BMC Cell Biology, 2004
Background The autosomal dominant form of Emery-Dreifuss muscular dystrophy (AD-EDMD) is caused by mutations in the gene encoding for the lamins A and C (LMNA).
Ewald Andrea, Motsch Isabell, Krüger Eleonora, Dreger Christine, Klafke Ruth, Reichart Beate, Schäfer Jochen, Reichmann Heinz, Müller Clemens R, Dabauvalle Marie-Christine   +9 more
doaj  

Leave It to Me: Overconfident CEOs’ Lower Propensity to Delegate Acquisition Responsibility

Journal of Management Studies, EarlyView.
Abstract Overconfident CEOs have been shown to lead their firms to achieve different outcomes, but the literature has only a limited understanding why this is the case. In this paper, we focus on whether overconfident CEOs run their firms differently, focusing on a key internal interaction: CEOs' choices regarding whether to delegate to other ...
Matthew Josefy, Jared Smith, Daniel Greene   +2 more
wiley   +1 more source

A Multifunctional β‐Defensin‐3 Mimetic Peptide Modulates Host–Biofilm Interactions and Reduces Bone Loss in Periodontitis

Journal of Periodontal Research, EarlyView.
BDMP, a peptide that can penetrate cells and tissues, offering antimicrobial and anti‐inflammatory effects, has been identified as a potential new therapy for periodontitis. ABSTRACT Aim This study evaluated the potential of a beta‐defensin‐3 mimetic peptide (BDMP), a synthetic cell‐penetrating peptide with antimicrobial and immunomodulatory properties,
Beom Soo Jo, Dong Woo Lee, Ji‐Young Lee, Sanghui Seok, Yu‐Bin Kim, Jue‐Yeon Lee, Shin‐Young Park, Young Dan Cho, Yang Jo Seol, Yoon Shin Park, Shahram Ghanaati, Homayoun H. Zadeh, Chong Pyung Chung, Yoon Jeong Park   +13 more
wiley   +1 more source

[A-type lamins and progeroïd syndromes : persistent farnesylation with dramatic effects].

Medecine sciences : M/S, 2008
Hutchinson-Gilford Progeria (HGPS), a rare and severe developmental disorder characterized by features recalling premature aging, and Restrictive Dermopathy (RD), a neonatal lethal genodermatosis, have recently been identified as being primary or secondary >. These heterogeneous disorders are caused by altered Lamin maturation pathway. In physiological
Navarro, Claire, Poitelon, Yannick, Lévy, Nicolas   +2 more
openaire   +2 more sources

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

A Highly Conserved SNARE‐Associated Protein Enhances Plant Immunity by Regulating Vesicle Trafficking

Plant Biotechnology Journal, EarlyView.
ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk, Peitong Li, Hafiz Muhammad Khalid Abbas, Mst Shamira Sultana, Sarbottam Piya, Nicole Coffey, Cengizhan Öztürk, Sobhan Bahrami Zadegan, Susan Thomas Laird, Mazen Alazem, Samantha P. Nuzzi, J. Hollis Rice, Chris Wyman, Tessa Burch‐Smith, Vince Pantalone, Tarek Hewezi   +15 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source