Results 261 to 270 of about 1,727,162 (300)

A-type lamins: Guardians of the soma?

Nature Cell Biology, 2004
The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of transcription factors required for
Chris J, Hutchison, Howard J, Worman
openaire   +2 more sources

Long-Term Efficacy and Safety of ARRY-371797 (PF-07265803) in Patients With Lamin A/C-Related Dilated Cardiomyopathy.

American Journal of Cardiology, 2022
Dilated cardiomyopathy associated with lamin A/C (LMNA) gene variants (LMNA-related dilated cardiomyopathy [DCM]) is a life-threatening condition with a high unmet need, accounting for approximately 6% of idiopathic DCM cases.
D. Judge, N. Lakdawala, M. Taylor, L. Mestroni, Huihua Li, Colleen Oliver, F. Angeli, Patrice A Lee, C. Macrae   +8 more
semanticscholar   +1 more source

Laminopathies and A-type lamin-associated signalling pathways

Advances in Enzyme Regulation, 2010
IntroductionThe nuclear envelope (NE) is the most important border in the eukaryotic cells, essential inmaintaining the identity of the nuclear and cytoplasmic compartments and in allowing additionallevels of regulation and control of the gene expression.
Maraldi NM, Lattanzi G, Cenni V, Bavelloni A, Marmiroli S, Manzoli FA   +5 more
openaire   +3 more sources

A Slice-Type Magnetoelectric Laminated Current Sensor

IEEE Sensors Journal, 2015
This paper describes the design and the implementation of a new structure for an ac current sensor based on a magnetoelectric laminated composite slice. Two layers of longitudinally magnetized magnetostrictive material Terfenol-D (Tb0.3Dy0.7Fe1.92) and one layer of transversely polarized piezoelectric material Pb(Zr,Ti)O3 (PZT) were epoxy-bonded and ...
Xinjie Yu, Guofeng Lou, Hongge Chen, Chao Wen, Shihua Lu   +4 more
openaire   +1 more source

Lamina-associated polypeptide 2α binds intranuclear A-type lamins

Journal of Cell Science, 2000
ABSTRACT The nucleoskeletal protein lamina-associated polypeptide 2α (LAP2α) contains a large, unique C terminus and differs significantly from its alternatively spliced, mostly membrane-integrated isoforms, such as LAP2β. Unlike lamin B-binding LAP2β, LAP2α was found by confocal immunofluorescence microscopy to colocalize preferentially
T, Dechat, B, Korbei, O A, Vaughan, S, Vlcek, C J, Hutchison, R, Foisner   +5 more
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SUV39h‐ and A‐type lamin‐dependent telomere nuclear rearrangement

Journal of Cellular Biochemistry, 2010
AbstractTelomeres are specialized chromatin structures that are situated at the end of linear chromosomes and play an important role in cell senescence and immortalization. Here, we investigated whether changes in histone signature influence the nuclear arrangement and positioning of telomeres.
Radka, Uhlírová, Andrea Harnicarová, Horáková, Gabriela, Galiová, Sona, Legartová, Pavel, Matula, Miloslava, Fojtová, Miroslav, Varecha, Jana, Amrichová, Jan, Vondrácek, Stanislav, Kozubek, Eva, Bártová   +10 more
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A-type nuclear lamins, progerias and other degenerative disorders

Mechanisms of Ageing and Development, 2005
Nuclear lamins were identified as core nuclear matrix constituents over 20 years ago. They have been ascribed structural roles such as maintaining nuclear integrity and assisting in nuclear envelope formation after mitosis, and have also been linked to nuclear activities including DNA replication and transcription. Recently, A-type lamin mutations have
Erica D, Smith, Brian A, Kudlow, Richard L, Frock, Brian K, Kennedy   +3 more
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A-type lamin-linked lipodystrophies.

Novartis Foundation symposium, 2005
Lipodystrophies represent a group of diseases characterized by altered body fat repartition and major metabolic alterations with insulin resistance. Genetic forms of partial lipodystrophy are currently recognized as two syndromes with subcutaneous lipoatrophy but preserved or increased fat at the level of face and neck (Dunnigan syndrome or FPLD due to
Corinne, Vigouroux, Jacqueline, Capeau
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Identification of novel phosphorylation sites in murine A‐type lamins

European Journal of Biochemistry, 1993
We report the distribution of phosphorylation sites in murine lamins A and C (A‐type lamins) in vitro and in vivo followed by reverse‐phase high‐performance liquid chromatography and micro‐sequencing of peptides spanning the almost complete lamin sequence. We show that two distinct protein kinases, cell‐division‐cycle‐2 kinase (cdc2 kinase) and protein
M, Eggert, N, Radomski, D, Linder, D, Tripier, P, Traub, E, Jost   +5 more
openaire   +2 more sources

Lamin A/C Expression in Hematopoietic Cells Declines During Human Aging and Constrains Atherosclerosis in Mice

Arteriosclerosis, Thrombosis and Vascular Biology
BACKGROUND: Aging is the primary risk factor for atherosclerosis, a degenerative process regulated by immune cells and the leading cause of death worldwide.
M. Amorós-Pérez, Alberto Del Monte-Monge, Pilar Gonzalo, M. Andrés-Manzano, Cristina Rius, Víctor Fanjul, Cristina González-Gómez, Guillermo Moreno, A. Benguría, A. Dopazo, F. Sánchez-Cabo, C. Torroja, Fernando Martínez de Benito, B. Calì, Pablo Vargas, Carlos Silvestre-Roig, J. González-Granado, Héctor Bueno, J. J. Fuster, Vicente Andrés   +19 more
semanticscholar   +1 more source