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The cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes. [PDF]
J Cell BiolShen KM +14 more
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Integration of nuclear mechanosensing with integrin-extracellular matrix adhesions. [PDF]
NucleusSandria S, King MC.
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Lamina-associated domains: Tethers and looseners
Current Opinion in Cell Biology, 2022 Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation ...
Bas van Steensel, Lise Dauban
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CTCF supports preferentially short lamina-associated domains
Chromosome Research, 2022More than one third of the mammalian genome is in a close association with the nuclear lamina, thus these genomic regions were termed lamina-associated domains (LADs). This association is fundamental for many aspects of chromatin biology including transcription, replication, and DNA damage repair.
Lukasz Stanislaw Kaczmarczyk +4 more
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Genome regulation at the peripheral zone: lamina associated domains in development and disease
Current Opinion in Genetics and Development, 2014The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture
Teresa Romeo Luperchio +2 more
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Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains [PDF]
Nature Genetics, 2011 Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale studies have yielded important insights into these changes but have focused on CpG islands or gene promoters.
Daniel Weisenberger +2 more
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Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2α
Journal of Cell Science, 2000ABSTRACT Lamina-associated polypeptide 2α (LAP2α) is a non-membrane-bound isoform of the LAP2 family involved in nuclear structure organization. Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death-inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that ...
J, Gotzmann, S, Vlcek, R, Foisner
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Nonspecific steric hindrance of protein particles by lamina-associated domains
Genomic organization within the nucleus is crucial for gene regulation and cell health, as disruptions in this organization are linked to genetic disorders and cancers. Recent studies suggest that molecular-scale organization of chromatin near the nuclear periphery (lamina-associated domains, LADs) affects gene regulation, providing transciptional ...Naz Bardakcı +2 more
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Summary Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which can be classified into two subtypes (T1 and T2) based on their level of lamina-association.
Chujing Zhang +8 more
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Chujing Zhang +8 more
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