Results 201 to 210 of about 23,804 (222)

Nuclear Mechanics and Nuclear Mechanotransduction in Cancer Cell Migration and Invasion. [PDF]

Biomolecules
Mierke CT.
europepmc   +1 more source

Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains. [PDF]

Proc Natl Acad Sci U S A
Beckner RL, Kim L, Carter C, Walterscheid A, Liszczak G.   +4 more
europepmc   +1 more source

Computational Characterization of the Role of LEM2/LaminA Interactions on the Stability of BAF-Dimer Using Molecular Simulations. [PDF]

Proteins
Muthachikavil AV, von Appen A, Kühne TD.   +2 more
europepmc   +1 more source

Lamina-associated domains: Tethers and looseners

Current Opinion in Cell Biology, 2022
Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled. Here, we review recent progress in the search for molecular tethers and looseners of LADs and we discuss the link between LAD-NL tethering, transcription regulation ...
Bas Van Steensel, Lise Dauban
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

CTCF supports preferentially short lamina-associated domains

Chromosome Research, 2022
More than one third of the mammalian genome is in a close association with the nuclear lamina, thus these genomic regions were termed lamina-associated domains (LADs). This association is fundamental for many aspects of chromatin biology including transcription, replication, and DNA damage repair.
Lukasz Stanislaw Kaczmarczyk, Nehora Levi, Tamar Segal, Mali Salmon-Divon, Gabi Gerlitz   +4 more
openaire   +2 more sources

Genome regulation at the peripheral zone: lamina associated domains in development and disease

Current Opinion in Genetics and Development, 2014
The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture
TERESA Romeo Luperchio, Xianrong Wong, Karen Reddy   +2 more
exaly   +3 more sources

Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells [PDF]

EMBO Reports, 2015
In mammals, the nuclear lamina interacts with hundreds of large genomic regions, termed lamina-associated domains (LADs) that are generally in a transcriptionally repressed state. Lamins form the major structural component of the lamina and have been reported to bind DNA and chromatin.
Bas Van Steensel, Mario Amendola
exaly   +4 more sources

Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2α

Journal of Cell Science, 2000
ABSTRACT Lamina-associated polypeptide 2α (LAP2α) is a non-membrane-bound isoform of the LAP2 family involved in nuclear structure organization. Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death-inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that ...
J, Gotzmann, S, Vlcek, R, Foisner
openaire   +2 more sources

Nonspecific steric hindrance of protein particles by lamina-associated domains

Genomic organization within the nucleus is crucial for gene regulation and cell health, as disruptions in this organization are linked to genetic disorders and cancers. Recent studies suggest that molecular-scale organization of chromatin near the nuclear periphery (lamina-associated domains, LADs) affects gene regulation, providing transciptional ...
Naz Bardakcı, Aykut Erbaş, Ozan S. Sarıyer   +2 more
openaire   +1 more source

Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

Summary Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which can be classified into two subtypes (T1 and T2) based on their level of lamina-association.
Chujing Zhang, Eugene Gil, Sajad Hamid Ahanger, Lynn Mingcong Li, Li Wang, Eric J. Huang, Jingjing Li, Arnold R. Kriegstein, Daniel A. Lim   +8 more
openaire   +2 more sources