Results 181 to 190 of about 8,868,086 (239)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Deep learning enabled prediction of nuclear lamina-associated chromatin. [PDF]

Patterns (N Y)
Das P, Lee JT.
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Histone acetyltransferase HAT1 regulates intestinal stem cell proliferation and differentiation. [PDF]

J Biol Chem
Nagarajan P, Martin CJ, Keller AR, Akkaya-Colak KB, Festing MH, Mihaylova MM, Parthun MR.   +6 more
europepmc   +1 more source

Single‐Sensor Vibration Sensing in Anisotropic Composites Enabled by Disordered Metasurfaces

Advanced Science, EarlyView.
This work develops a single‐sensor vibration sensing (SSVS) framework that integrates disordered metasurfaces with compressive sensing. Comprehensive numerical and experimental validations demonstrate that, by manipulating anisotropic guided wave propagation through metasurfaces, the proposed SSVS framework enables high‐fidelity multi‐source vibration ...
Jianjie Zhang, Lanhe Xu, Zhongzheng Zhang, Yongbo Li, Eric Li, Asoke K. Nandi, Bing Li   +6 more
wiley   +1 more source

Lamin A/C as a Molecular Link Between Nuclear Organization, Chromatin Dynamics, and Tumor Progression. [PDF]

Cells
Foglini C, Scotlandi K, Pasello M.
europepmc   +1 more source

Trace Li Pre‐Doping of Activated Carbon Cathode Enabling Accelerated Li‐Ion Transport for High‐Power Lithium‐Ion Capacitors

Advanced Science, EarlyView.
Trace‐level Li pre‐doping on activated carbon cathodes is demonstrated to significantly enhance Li‐ion transport and high‐rate performance in lithium‐ion capacitors. An ultrathin Li2CO3 interfacial layer, formed through controlled thermal conversion, facilitates rapid ion transport without pore blockage.
Kyungmin Do, Jihyeon Ryu, Dong Gyun Im, Seong‐Yong Kim, Tae‐Hyun Kwon, Byeong Guk Kim, Seojin Jeon, Woosun Jang, Myoung Joon Hwang, Ki‐Hun Nam, Seung Yol Jeong, Ick‐Jun Kim, Seungwook Eom, Jaeik Hyun, Sunhye Yang   +14 more
wiley   +1 more source

Vectored Immunoprophylaxis for Mucosal Immunity: Advances and Challenges Associated with Recombinant Secretory IgA Expression. [PDF]

Vaccines (Basel)
Manchester BJ, Gommerman JL, Sharif S, Susta L, Wootton SK.   +4 more
europepmc   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Epistemological parameters in the recent era of nuclear organization and function. [PDF]

Mol Biol Cell
Pederson T.
europepmc   +1 more source