Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF [PDF]
International audienceThe localization of genes within the nuclear space is of paramount importance for proper genome functions. However, very little is known on the cis-acting elements determining subnuclear positioning of chromosome segments.
Schluth-Bolard, Caroline +13 more
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Implications for Diverse Functions of the LINC Complexes Based on the Structure
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins.
Miki Hieda
doaj +1 more source
Role of Nuclear Lamins in Nuclear Organization, Cellular Signaling, and Inherited Diseases
Lamins are the major architectural proteins of the nucleus and are essential for nuclear integrity and assembly. Lamins are also involved in the organization of nuclear functions such as DNA replication, transcription, and repair.
Parnaik, Veena K., Veena K. Parnaik
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Internal iamin structures within G1 nuclei of human dermal fibroblasts [PDF]
The nuclear lamina is a mesh-like network of fibres subjacent to the inner nuclear membrane that is believed to be involved in the specific spatial reorganisation of chromatin after mitosis.
Kill, IR +3 more
core +1 more source
Robert Feulgen Lecture | LAMINS IN NUCLEAR ORGANISATION AND CHROMATIN REGULATION
Lamins form a filamentous network at the nuclear envelope that anchors heterochromatin and repressed genes to the nuclear periphery. Lamin A also exists as a non-filamentous pool in the nuclear interior, where it interacts with lamin-associated ...
doaj +1 more source
Lamin subtype expression in Merkel-cell carcinoma: its relation to polyomavirus infection and tumor metastasis. [PDF]
Stiekema M +10 more
europepmc +1 more source
An Unbiased Drug Screen in a Drosophila Model of <i>LMNA</i>-Muscular Dystrophy Identifies Calcium Channel Blockers as Potential Treatments. [PDF]
Mohar NP +9 more
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Lamin-ating the genome: quantitative gatekeeping of replication initiation. [PDF]
Parasar B, Moghadami S, Tan L.
europepmc +1 more source
The Lamin Proteins in Nuclear Structure, Functions, and Laminopathies. [PDF]
Zhao G +5 more
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