Results 71 to 80 of about 9,924 (194)
Cell Reports, 2018 Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a truncated lamin A protein (progerin) that drives cellular and organismal decline.
Ray Kreienkamp +9 more
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Functions and Regulation of Nuclear Lamins in Health and Disease [PDF]
, 2014 Nuclear lamins are intermediate filament proteins that form the nuclear lamina, a structural scaffolding for the nucleus. They interact with other nuclear proteins and the chromatin and are thought to participate in many fundamental cellular pathways ...
Jung, Hea Jin
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Insight into the functional organization of nuclear lamins in health and disease
, 2018 Lamins are the main component of the nuclear lamina, a protein meshwork at the inner nuclear membrane which primarily provide mechanical stability to the nucleus. Lamins, type V intermediate filament proteins, are also involved in many nuclear activities.
Meltem Tatli +5 more
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Quantitative Analysis of Nuclear Lamins Imaged by Super-Resolution Light Microscopy
Cells, 2019 The nuclear lamina consists of a dense fibrous meshwork of nuclear lamins, Type V intermediate filaments, and is ~14 nm thick according to recent cryo-electron tomography studies.
Mark Kittisopikul +3 more
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An investigation into the role of lamin A in the progression of colorectal cancer [PDF]
, 2005 Nuclear lamins are type V intermediate filaments which form a proteinaceous meshwork, termed the nuclear lamina, which underlines the inner nuclear membrane and provides mechanical strength to the nucleus and maintains nuclear shape.
Willis, Naomi Daphne
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Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]
, 1994 The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Hutchison, CJ +3 more
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The cell nucleus. A study in Burgundy
Nucleus, 2019 Wilhelm Bernhard’s revolutionary microscopy techniques helped him put forward the hypothesis of specialized compartmentalization of the nucleus. He also described for the first time the nuclear bodies and peri-chromatin fibrils, and demonstrated that ...
Oleg Demidov +3 more
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Unveiling karyoskeletal dynamics in chromatin organization and gene regulation in haematopoietic cell physiology and pathology [PDF]
Open BiologyChromatin organization and gene regulation are essential for maintaining homeostatic haematopoiesis, the tightly regulated process by which haematopoietic stem and progenitor cells generate diverse blood lineages.
Mohd Kamran +2 more
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In Practice, 2012 Laminitis is a common and painful condition of adult equids that often results in permanent lameness or euthanasia. In recent years, our knowledge of the condition has developed and this article discusses the current understanding of laminitis and approaches to its treatment and prevention.
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Lamins and chromatin join forces [PDF]
The intricate interplay between lamins and chromatin underpins the structural integrity and functional organization of the eukaryotic nucleus. Lamins, type V intermediate filament proteins, form a robust meshwork beneath the inner nuclear membrane that ...
Luo, Qiang +2 more
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