Results 21 to 30 of about 28,888 (167)

Management of Antiviral Resistance in Chronic Hepatitis B

Gut and Liver, 2017
The primary goal of therapy for chronic hepatitis B (CHB) is to prevent liver disease progression. Hepatitis B surface antigen (HBsAg) seroclearance or seroconversion is regarded as an optimal endpoint to discontinue treatment.
Young-Suk Lim
doaj   +1 more source

Treatment of subacute hepatitis B with lamivudine: A pilot study in Serbia [PDF]

Vojnosanitetski Pregled, 2009
Background/Aim. The incidence of acute hepatitis B viral (HBV) infection in adults has increased in recent years in Serbia. Most icteric patients with acute hepatitis B resolve their infection and do not require treatment.
Delić Dragan, Nešić Zorica, Prostran Milica, Boričić Ivan, Svirtlih Neda   +4 more
doaj   +1 more source

Successful lamivudine therapy for chronic hepatitis B in the family [PDF]

Vojnosanitetski Pregled, 2006
Background. Hepatitis B virus infection is a global public health problem since it is a leading cause of liver cirrhosis and hepatocellular carcinoma. An optimal treatment is needed to reduce mortality.
Nožić Darko
doaj   +1 more source

Effects of Trimethoprim on Three Previously Proposed Putative Biomarkers for OCT2/MATE‐Mediated Renal Drug‐Drug Interactions in Healthy Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Regulatory agencies request the assessment of the potential of new drugs to cause transporter‐mediated drug‐drug interactions (DDI). This assessment can be improved by integrating endogenous biomarkers during drug development. Regarding the renal excretion of drugs such as metformin, the organic cation transporter (OCT) 2 and multidrug and toxin ...
Jana Picurová, Fabian Müller, Daniel Auge, Jörg König, Martin F. Fromm, Arne Gessner   +5 more
wiley   +1 more source

Green HPLC quantification method of lamivudine, zidovudine and nevirapine with identification of related substances in tablets

Green Chemistry Letters and Reviews, 2022
A green HPLC method for lamivudine (3TC), zidovudine (AZT) and nevirapine (NVP) determination in fixed-dose combination tablets was developed using ethanol as both one of the mobile phases and the solvent for sample preparation. This method was validated
Ludivine Vieira-Sellaï, Mercedes Quintana, Ousmane Diop, Olivier Mercier, Sebastien Tarrit, Nawal Raimi, Alassan Ba, Benoit Maunit, Marie-Josephe Galmier   +8 more
doaj   +1 more source

The Effects of Compulsory Licensing: A Case Study of HIV Drugs

Health Economics, EarlyView.
ABSTRACT Compulsory licensing is a legal mechanism that allows governments the use of patented medicines without the owner's consent, subject to conditions and compensation, to meet public‐health needs. Despite its policy relevance and increasing use, empirical evidence on its market effects remains limited.
Nicolau Martin‐Bassols, Miquel Serra‐Burriel, Kerstin Noelle Vokinger   +2 more
wiley   +1 more source

Human papillomavirus persistence and clearance in women living with HIV: A five‐year retrospective analysis from an Italian university center

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In women living with HIV, HPV clearance occurred after a mean of approximately 2 years under antiretroviral therapy. Baseline positivity for the high‐risk HPV pool was associated with delayed clearance, suggesting that HPV genotype may influence viral persistence more than immunovirological status in clinically stable patients.
Annunziata Carlea, Dario Colacurci, Giorgia D'Apice, Laura Letizia Mazzarelli, Massimiliano Pellicano, Luigi Falco, Ginevra Sepe, Oriana Imperatore, Giuseppe Maria Maruotti, Maurizio Guida, Laura Sarno   +10 more
wiley   +1 more source

Temporal shifts in antiretroviral therapy regimens and metabolic outcomes in people living with HIV: A systematic review and meta‐analysis

HIV Medicine, EarlyView.
Abstract Introduction Antiretroviral therapy (ART) for people living with HIV has led to dramatically reduced mortality and improved life expectancy. This achievement is accompanied by a higher risk for metabolic and other non‐communicable diseases. The role and contribution of various ART regimens to adverse metabolic outcomes are not fully understood.
Melani Ratih Mahanani, Myo Chit, Sophie Mohr, Elisenda Cama i Gibernau, Svetlana Hetjens, Volker Winkler, Hans‐Michael Steffen, Florian Neuhann   +7 more
wiley   +1 more source

Susceptibility of Primary HTLV-1 Isolates from Patients with HTLV-1-Associated Myelopathy to Reverse Transcriptase Inhibitors

Viruses, 2011
Since human T-lymphotropic virus type 1 (HTLV-1)-associated diseases are associated with a high HTLV-1 load, reducing this load may treat or prevent disease.
Antonio Mastino, Graham P Taylor, Beatrice Macchi, Emanuela Balestrieri, Arianna Ascolani, Silva Hilburn, Fabiola Martin   +6 more
doaj   +1 more source

HIV drug resistance and treatment success in the Republic of Congo: Implications for optimized treatment

HIV Medicine, EarlyView.
Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning, Arcy Marcelin Elenga Ike, Johanna Holterhoff, Amira Stockinger, Darrel Ornelle Elion Assiana, Claujens Chastel Mfoutou Mapanguy, Freisnel Hermeland Mouzinga, Carola Horn, Isabelle Suarez, Ferdinand Heyn, Diane Alexia Fila, Hubert Banguissa, Fabien Roch Niama, Donatien Moukassa, Eva Heger, Francine Ntoumi, Clara Lehmann   +16 more
wiley   +1 more source