Results 31 to 40 of about 149,549 (315)

Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells [PDF]

, 1995
I-E is a class II major histocompatibility complex molecule normally expressed by Langerhans cells, A series of transgenic mice were developed previously that carry Eαd gene constructs with promoter-region deletions that cause expression of I-E by ...
Ding, Tie-Gang, Edelson, Richard, Flavell, Richard, Levin, Ditza, Lewis, Julia, Longley, Jack, Tigelaar, Robert   +6 more
core   +1 more source

From simplicity to complexity in current melanoma models

Experimental Dermatology, Volume 31, Issue 12, Page 1818-1836, December 2022., 2022
Abstract Despite the recent impressive clinical success of immunotherapy against melanoma, development of primary and adaptive resistance against immune checkpoint inhibitors remains a major issue in a large number of treated patients. This highlights the need for melanoma models that replicate the tumor's intricate dynamics in the tumor ...
Elisabetta Michielon, Tanja D. de Gruijl, Susan Gibbs   +2 more
wiley   +1 more source

Shaping bursting by electrical coupling and noise [PDF]

Biological Cybernetics Volume 106, Number 2 (2012), 67-88, 2011
Gap-junctional coupling is an important way of communication between neurons and other excitable cells. Strong electrical coupling synchronizes activity across cell ensembles. Surprisingly, in the presence of noise synchronous oscillations generated by an electrically coupled network may differ qualitatively from the oscillations produced by uncoupled ...
arxiv   +1 more source

Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. [PDF]

, 2003
Exposure to ultraviolet-B radiation impairs cellular immune responses. This immunosuppression seems to be associated with Langerhans cell migration. DNA damage appears to play a key role because enhanced nucleotide excision repair, a pathway essential ...
Applegate, Berg, Boonstra, Chen, Cheo, Cruz, Cumberbatch, Cumberbatch, De Boer, de Vries, Frank R. de Gruijl, Garssen, Garssen, Gijsbertus T.J. van der Horst, Goettsch, Hanawalt, Harry van Steeg, Hurks, Jan H.J. Hoeijmakers, Jiang, Jimbo, Johan Garssen, Kölgen, Miyauchi-Hashimoto, Morison, Morison, Nishigori, Noonan, O'Connor, Okamoto, Petit-Frere, Pupe, Reeve, Ruven, Shreedhar, Sontag, Sontag, Tan, Tang, Tang, van der Horst, Van Oosten, Vink, Wendy Kölgen, Willem A. van Vloten, Wolf, Yarosh, Yarosh   +47 more
core   +2 more sources

Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response [PDF]

PLoS ONE 8(8): e70366 (2013), 2013
Cells of almost all solid tissues are connected with gap junctions which permit the direct transfer of ions and small molecules, integral to regulating coordinated function in the tissue. The pancreatic islets of Langerhans are responsible for secreting the hormone insulin in response to glucose stimulation.
arxiv   +1 more source

Langerhans Cell Sarcoma: A Case Report Demonstrating Morphological and Immunophenotypical Variability within a Single Lesion

Case Reports in Pathology, 2017
Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and ...
Rasika Singh, Charles Edward Keen, Christopher Stone, Patrick Sarsfield   +3 more
doaj   +1 more source

Langerhans cell histiocytosis [PDF]

Blood, 2020
Abstract Langerhans cell histiocytosis (LCH) is caused by clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in lesions that leads to a spectrum of organ involvement and dysfunction. The pathogenic cells are defined by constitutive activation of the MAPK signaling pathway.
Carl E. Allen, Carlos Rodriguez-Galindo
openaire   +3 more sources

The effects of beta-cell mass and function, intercellular coupling, and islet synchrony on $\textrm{Ca}^{2+}$ dynamics [PDF]

, 2020
Type 2 diabetes (T2D) is a challenging metabolic disorder characterized by a substantial loss of $\beta$-cell mass and alteration of $\beta$-cell function in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. The mechanisms for deficiency in $\beta$-cell mass and function during the hyperglycemia development and T2D ...
arxiv   +1 more source

Pulmonary Langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child

The Egyptian Journal of Internal Medicine, 2015
Bilateral pneumothorax is very rare in childhood. Moreover, if it is due to pulmonary involvement of Langerhans cell histiocytosis, it is even rarer in childhood.
Anupam Patra, Sujit K Bhattacharyay, Arnab Maji, Abhijit Mandal   +3 more
doaj   +1 more source

Islet isolation assessment in man and large animals [PDF]

, 1990
Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet yield.
Alejandro, R, Bretzel, RG, Carlo, VD, Falqui, L, Federlin, K, Gray, DWR, Hering, BJ, James, RFL, Kaufman, DB, Kneteman, NM, Lacy, PE, Lake, SP, London, NJM, Mintz, DH, Morris, PJ, Pozza, G, Rajotte, RV, Ricordi, C, Scharp, DW, Socci, C, Starzl, TE, Sutherland, DER, Tzakis, A, Viviani, G, Warnock, GL, Zeng, Y   +25 more
core   +1 more source