A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting
bioRxiv, 2018 Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines.
Eike-Christian Wamhoff +13 more
semanticscholar +1 more source
High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis.
Blood, 2017 Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that most commonly affects adults and is driven by a high frequency of mutations in BRAF, MAP2K1, and kinases promoting MAPK signaling.
M. Papo +22 more
semanticscholar +1 more source
Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells [PDF]
, 1995 I-E is a class II major histocompatibility complex molecule normally expressed by Langerhans cells, A series of transgenic mice were developed previously that carry Eαd gene constructs with promoter-region deletions that cause expression of I-E by ...
Ding, Tie-Gang +6 more
core +1 more source
Case Reports in Pathology, 2017 Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and ...
Rasika Singh +3 more
doaj +1 more source
Hematopoietic origin of Langerhans cell histiocytosis and Erdheim-Chester disease in adults.
Blood, 2017 Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) are rare histiocytic disorders induced by somatic mutation of MAPK pathway genes. BRAFV600E mutation is the most common mutation in both conditions and also occurs in the hematopoietic
Paul Milne +16 more
semanticscholar +1 more source
Pulmonary Langerhans cell histiocytosis causing spontaneous bilateral pneumothorax in a child
The Egyptian Journal of Internal Medicine, 2015 Bilateral pneumothorax is very rare in childhood. Moreover, if it is due to pulmonary involvement of Langerhans cell histiocytosis, it is even rarer in childhood.
Anupam Patra +3 more
doaj +1 more source
Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis.
Blood, 2016 Langerhans cell histiocytosis (LCH) is characterized by inflammatory lesions containing pathologic CD207+ dendritic cells with constitutively activated ERK.
Rikhia Chakraborty +15 more
semanticscholar +1 more source
Specific Protein Antigen Delivery to Human Langerhans Cells in Intact Skin
Frontiers in Immunology, 2021 Immune modulating therapies and vaccines are in high demand, not least to the recent global spread of SARS-CoV2. To achieve efficient activation of the immune system, professional antigen presenting cells have proven to be key coordinators of such ...
Mareike Rentzsch +14 more
doaj +1 more source
Islets of Langerhans Are Protected from Inflammatory Cell Recruitment during Reperfusion of Rat Pancreas Grafts [PDF]
, 2010 Background: Ischemia/reperfusion (I/R) injury plays a pivotal role in the development of graft pancreatitis, with ischemia time representing one of its crucial factors.
Eichhorn, M. E. +6 more
core +1 more source
Langerhans' Cell Histiocytosis
Dermatology Online Journal, 2002 Adult onset Langerhans cell histiocytosis is uncommon. A 29 year old man is presented who developed classic cutaneous disease with severe systemic involvement. He responded completely to a two month course of thalidomide.
Mortazavi, Hessein +3 more
openaire +4 more sources