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Langerhans Cell Histiocytosis [PDF]
Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Its clinical presentation is variable and ranges from isolated skin or bone disease to a life-threatening multisystem condition. LCH can occur at any age but is more frequent in the pediatric population. A neoplastic origin of this disease has been suggested
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Background Langerhans cells constitute a special subset of immature dendritic cells localized in the epidermis that play a key role in the skin's immune response.
da Silva Jorge P+4 more
doaj +1 more source
Definition: A histiocytary proliferation of granuloma-like aspect with unknown etiology that may involve bone marrow, internal organs, skin, and mucosae.
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Rho-associated kinase regulates Langerhans cell morphology and responsiveness to tissue damage
Summary: Skin damage requires efficient immune cell responses to restore organ function. Epidermal-resident immune cells known as Langerhans cells use dendritic protrusions to surveil the skin microenvironment, which contains keratinocytes and peripheral
Eric Peterman+3 more
doaj
Assessment of antigen presenting cell infiltration in lung tissues of patients with bronchiectasis
Background: Bronchiectasis is a chronic disease characterized by permanent dilatation of the conducting airways accompanied by sustained inflammation. Aims: To assess whether chronic inflammation of lungs in bronchiectasis is associated with alterations ...
Waseem M Hajjar+5 more
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A histiocitose de células de Langerhans é proliferação clonal de células fenotipicamente semelhantes às células de Langerhans. Anteriormente denominada Letterer-Siwe, é a forma mais comum e mais grave dessa enfermidade, acometendo sobretudo crianças até ...
Leonardo Mello Ferreira+4 more
doaj +1 more source
Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis.
Sergio E. Rodriguez+3 more
doaj +1 more source
Background: Patients with Langerhans cell histiocytosis are at particularly high risk for central diabetes insipi-dus (CDI) due to hypothalamic-pituitary disease. Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the
Zahra Alian+2 more
doaj
SERIAL RECONSTRUCTION OF THE CHARACTERISTIC GRANULE OF THE LANGERHANS CELL [PDF]
Richard W. Sagebiel, Thomas H. Reed
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Lactobacilli have immunomodulatory mechanisms that affect the host cell immune system, leading to inhibition of HIV-1 transmission. Thus, lactobacilli as mucosal delivery vehicles for developing HIV-1 vaccines have attracted interest in recent years ...
Jie Song+10 more
doaj +1 more source