Results 51 to 60 of about 21,208 (178)
Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, Volume 13, Issue 53, 24 September 2026.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
IL‐22Rα1 restrains pancreatic injury independently of its C‐terminal STAT3‐amplifying domain
Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.IL‐22R, and to a lesser extent IL‐22, are key drivers of protection in acute pancreatitis. Although the C‐terminal domain of IL‐22R enhances STAT3 activation in the pancreas, it is not required for disease protection. Classical IL‐22R signaling alone is sufficient to control inflammation and promote pancreatic recovery.
Léna Puigdevall +4 more
wiley +1 more source
Current Protocols, Volume 6, Issue 9, September 2026.Abstract The most common treatment for people with people with type 1 diabetes (T1D) requires injections of exogenous insulin to regulate blood glucose homeostasis. A longer‐term therapeutic solution for T1D has emerged whereby patients may regain insulin independence through transplantation of donated human pancreatic islets, which contain insulin ...
Manuj Bandral +2 more
wiley +1 more source
Jurnal Veteriner, 2012 Morphology, distribution and relative frequency of endocrine cells in the pancreas Bullfrog (Ranacatesbeiana) were studied using conventional and immunohistochemical methods.
I Ketut Mudite Adnyane +3 more
doaj
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani +4 more
wiley +1 more source
VARIATION IN THE AREA OF ISLETS OF LANGERHANS IN SODIUM CYCLAMATE TREATED RATS
Pakistan Armed Forces Medical Journal, 2015 Objective: To observe the effects of sodium cyclamate on islets of langerhans in rats pancreas. Study Design: Laboratory based randomized control trial. Duration of study: Anatomy Department, Army Medical College Rawalpindi, in collaboration with
Hina Kundi +2 more
doaj +2 more sources
Antidiabetic effect of honey feeding in noise induced hyperglycemic rat: involvement of oxidative stress [PDF]
Iranian Journal of Basic Medical Sciences, 2015 Objective(s):In this study the effect of oral administration of honey on serum glucose, lipids, stress oxidative markers, and morphology of langerhans islets in noise induced hyperglycemic rats was investigated.
Saiedeh Arabmoazzen +3 more
doaj
iNew Medicine, Volume 2, Issue 3, September 2026.ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 1998 Nitric oxide synthase activity was measured in Langerhans islets isolated from control and streptozotocin diabetic rats. The activity of the enzyme was linear up to 150 µg of protein from control rats and was optimal at 0.1 µM calcium, when it was ...
T.M. Fonovich de Schroeder +3 more
doaj +1 more source
The Endothelial Cells in Islets of Langerhans [PDF]
Upsala Journal of Medical Sciences, 2005 The blood vessels of the pancreatic islets are of crucial importance for oxygen and metabolite supply, and dispersal of secreted hormones. In addition to this, endothelial cells have an important role in the revascularization process after islet transplantation.
openaire +2 more sources