Results 61 to 70 of about 633,545 (282)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Comment initier en mathématiques la production d’une notation et ses usages à partir de l’activité des élèves ?

Recherches en Éducation, 2011
We seek to describe verbal and non verbal interactions and how a teacher teaches mathematics in a learning situation where the production of mathematical concepts and a marking-system is developed from the pupils’ activity with the teacher’s guidance. We
Serge Quilio, Dominique Forest
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Les opérations intellectuelles des élèves et la perception de l’enseignante dans trois discussions à visée philosophique en classe de CP

Recherches en Éducation, 2016
In three philosophical discussions in a class of schoolchildren aged 6-7 years, we analyzed linguistic forms in successive utterances to establish the intellectual processes involved.
Lidia Lebas-Fraczak
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Usage des traces des interactions verbales pour la formation des personnels éducatifs et réflexion sur leur didactisation

Recherches en Éducation
This article discusses the use, in training, of traces of the language activity of Principal Education Advisors (CPE) during interviews with parents of pupils.
Claire Burdin
doaj   +1 more source

Relation texte-image : pratiques d’enseignement dans les situations de lecture d’albums au cycle 3, apprentissages élèves et « schème collectif »

Recherches en Éducation, 2015
This article is a contribution to the group analysis proposed in this issue. It is based on three studies of 3rd cycle’s cases during children’s literature class with the aim of broaching the connection between text and image, equally in the teaching and
Antonietta Specogna
doaj   +1 more source