Results 101 to 110 of about 17,586 (206)

The role of Coenzyme Q10 in statin-associated myopathy [PDF]

, 2009
Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors,\ud are cholesterol-lowering drugs which are frequently used in the primary and secondary\ud prevention of coronary artery disease. Current research and recommendations support\
Kalra, Dr Sanjay
core  

Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates.

Journal of Lipid Research, 1986
With [3H-24,25]-dihydrolanosterol as substrate, large-scale metabolic formation of intermediates of lanosterol demethylation was carried out to identify all compounds in the metabolic process.
A Shafiee, J M Trzaskos, Y K Paik, J L Gaylor   +3 more
doaj   +1 more source

Estudio de la fracción insaponificable obtenida del aceite extraído de la semilla de la luffa cylindrica [PDF]

, 2008
Se obtuvo y caracterizo la materia insaponificable del aceite de las semillas de la Luffa Cylindrica procedentes de Risaralda suministrada por la empresa ESTROCOL. La materia prima se sometio a un proceso de secado para la posterior extraccion del aceite
Arcila González, Luis F., Fernández Tenorio, Juliana   +1 more
core  

Candida infections, causes, targets and resistance mechanisms. Traditional and alternative antifungal agents [PDF]

, 2013
The genus Candida includes about 200 different species, but only a few species are human opportunistic pathogens and cause infections when the host becomes debilitated or immunocompromised. Candida infections can be superficial or invasive.
Leonardi, Darío, Spampinato, Claudia Patricia   +1 more
core   +3 more sources

Hairy Tongue [PDF]

, 2017
Hairy tongue (lingua villosa) is a commonly observed condition of defective desquamation of the filiform papillae that results from a variety of precipitating factors. [1] The condition is most frequently referred to as black hairy tongue (lingua villosa
Burgess, Jeff, Butler, David F., Eisen, Drore, Handler, Marc Zachary, Lynch, Denis P, Stafford, Gary L   +5 more
core   +1 more source

The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study

Atherosclerosis Plus
Background and aims: Hydroxychloroquine (HCQ) has a variable effect on cholesterol synthesis. To clarify this, we assessed the effect of HCQ on the cholesterol-synthesis pathway in individuals with low and high cholesterol absorption efficiency.
Piia Simonen, Lotta Ulander, Kari K. Eklund, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo   +6 more
doaj   +1 more source

Cholesterol metabolism during ketoconazole treatment in man.

Journal of Lipid Research, 1988
Ketoconazole, an antifungal antibiotic, inhibits cholesterol synthesis by blocking demethylation of lanosterol. Effects of this inhibition were studied on serum cholesterol, lipoproteins and cholesterol precursors, biliary lipid composition, and fecal ...
T A Miettinen
doaj   +1 more source

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]

, 2017
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc, Hirayama, Yuichiro, Houk, KN, Li, Dehai H, Li, Li, Tang, Mancheng C, Tang, Yi, Watanabe, Kenji, Zou, Yi   +8 more
core  

Amphotericin forms an extramembranous and fungicidal sterol sponge. [PDF]

, 2014
For over 50 years, amphotericin has remained the powerful but highly toxic last line of defense in treating life-threatening fungal infections in humans with minimal development of microbial resistance.
Anderson, Thomas M, Burke, Martin D, Cioffi, Alexander G, Clay, Mary C, Comellas, Gemma, Diaz, Katrina A, Gonen, Tamir, Hisao, Grant S, Maryum, Nashrah, Nieuwkoop, Andrew J, Rienstra, Chad M, Tuttle, Marcus D, Uno, Brice E, Wang, Shu, Wildeman, Erin L   +14 more
core  

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

Nature Communications
Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing the C14α-methyl group ...
Yiru Jin, Somrita Basu, Mei Feng, Yu Ning, Indeewara Munasinghe, Arline M. Joachim, Junan Li, Lingli Qin, Robert Madden, Hannah Burks, Philip Gao, Judy Qiju Wu, Salma Waheed Sheikh, April C. Joice, Chamani Perera, Karl A. Werbovetz, Kai Zhang, Michael Zhuo Wang   +17 more
doaj   +1 more source