Results 71 to 80 of about 6,528 (248)

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, Volume 4, Issue 1, Page 82-93, February 2026.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Decoding the Chemical Language of Ribosomally Synthesized and Post‐Translationally Modified Peptides from the Untapped Archaea Domain

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
Secondary metabolites (SMs) are essential across all life domains, yet those originating from the Archaea domain remain poorly understood. Here, the systematic genome mining and the pioneering heterologous expression of archaeal SMs have revealed the chemical landscape of archaeal lanthipeptides, showing both canonical and non‐canonical forms.
Zhi‐Man Song, Cunlei Cai, Ying Gao, Xiaoqian Lin, Qian Yang, Dengwei Zhang, Gengfan Wu, Haoyu Liang, Qianlin Zhuo, Junliang Zhang, Peiyan Cai, Haibo Jiang, Wenhua Liu, Yong‐Xin Li   +13 more
wiley   +2 more sources

Processing and Structure of the Lantibiotic Peptide Nso From the Human Gut Bacterium Blautia obeum A2-162 analysed by Mass Spectrometry [PDF]

, 2018
A previously reported gene cluster encoding four nisin-like peptides, three with the same sequence (NsoA1-3) and the unique NsoA4, produced antimicrobial activity in the presence of trypsin after heterologous expression in Lactococcus lactis.
Gherghisan-Filip, Cristina, Hatziioanou, Diane, Mayer, Melinda J., Narbad, Arjan, Saalbach, Gerhard   +4 more
core   +1 more source

An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Postbiotics have emerged as a promising alternative to live probiotics, offering comparable health benefits while overcoming challenges related to safety, stability, and shelf life. The review addresses current challenges in standardizing postbiotic definitions and production processes, and by outlining future research directions necessary to unlock ...
Michael Leonidas Chikindas, Diana E. Roopchand, Santosh Kumar Tiwari, Liubov S. Sichel, Mukund V. Karwe, Nitin Nitin, Vitor Luis Fagundes, Igor V. Popov, John R. Tagg, Xuanxuan Lu, Svetoslav Dimitrov Todorov   +10 more
wiley   +1 more source

Pharmacodynamic activity of the lantibiotic MU1140 [PDF]

International Journal of Antimicrobial Agents, 2009
This study evaluated the pharmacodynamics of the lantibiotic MU1140 and the ability of selected organisms to develop resistance to this antibiotic. MU1140 demonstrated activity against all Gram-positive organisms tested, including oxacillin- and vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis (VREF).
Oragenics Inc. Progress Blvd., Alachua, FL 32615, USA ( host institution ), Ghobrial, Oliver G., Derendorf, Hartmut, Hillman, Jeffery D.   +3 more
openaire   +3 more sources

Anthropogenic Disruption Versus Natural Restoration: Enterobacter cloacae‐Driven Barnacle Larval Settlement and Its Mitigation via Natural Bacteriophages

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
Anthropogenic‐derived E. cloacae colonises marine cooling water systems, where chlorine exposure drives cross‐resistance and enhances biofilm formation, creating hotspots for barnacle larval settlement. This work reveals a previously unrecognised mechanism linking microbial pollution to marine biofouling.
Atif Khan, Akash Saha, Hiren M. Joshi
wiley   +1 more source

Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction [PDF]

, 1995
The post-translationally modified, antimicrobial peptide nisin is secreted by strains of Lactococcus lactis that contain the chromosomally located nisin biosynthetic gene cluster nisABTCIPRKFEG.
Buchman, Casadaban, de Vos, de Vos, Engelke, Engelke, Fukase, Gallo, Gao, Gasson, Goodman, Gross, Gross, Gutowski-Eckel, Holo, Horinouchi, Hurst, Kaletta, Klein, Kuipers, Kuipers, Kuipers, Mattick, Mulders, Parkinson, Peschel, Piard, Piard, Platteeuw, Rauch, Sahl, Sahl, Sahl, Sanger, Schnell, Siegers, Stock, Tanaka, van der Meer, Wakamiya, Wakamiya, Wakamiya, Wanner, Yanisch-Perron   +43 more
core   +2 more sources

Biosynthesis of the Lantibiotic Mersacidin: Organization of a Type B Lantibiotic Gene Cluster

Applied and Environmental Microbiology, 2000
ABSTRACT The biosynthetic gene cluster (12.3 kb) of mersacidin, a lanthionine-containing antimicrobial peptide, is located on the chromosome of the producer, Bacillus sp. strain HIL Y-85,54728 in a region that corresponds to 348° on the chromosome of Bacillus subtilis 168.
K, Altena, A, Guder, C, Cramer, G, Bierbaum   +3 more
openaire   +3 more sources

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, Volume 1, Issue 1, Page 27-44, December 2025.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth

Frontiers in Microbiology, 2018
The mode of action of four cationic amphipathic antimicrobial peptides (AMPs) was evaluated against the non-pathogenic, Gram-positive, spore-forming bacterium, Bacillus subtilis. The AMPs were TC19, TC84, BP2, and the lantibiotic Nisin A.
Soraya Omardien, Jan Wouter Drijfhout, Sebastian A. Zaat, Stanley Brul   +3 more
doaj   +1 more source