Results 51 to 60 of about 2,586 (178)

Biosynthesis of the Lantibiotic Mersacidin: Organization of a Type B Lantibiotic Gene Cluster

Applied and Environmental Microbiology, 2000
ABSTRACT The biosynthetic gene cluster (12.3 kb) of mersacidin, a lanthionine-containing antimicrobial peptide, is located on the chromosome of the producer, Bacillus sp. strain HIL Y-85,54728 in a region that corresponds to 348° on the chromosome of Bacillus subtilis 168.
K, Altena, A, Guder, C, Cramer, G, Bierbaum   +3 more
openaire   +3 more sources

Pharmacodynamic activity of the lantibiotic MU1140 [PDF]

International Journal of Antimicrobial Agents, 2009
This study evaluated the pharmacodynamics of the lantibiotic MU1140 and the ability of selected organisms to develop resistance to this antibiotic. MU1140 demonstrated activity against all Gram-positive organisms tested, including oxacillin- and vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis (VREF).
Oragenics Inc. Progress Blvd., Alachua, FL 32615, USA ( host institution ), Ghobrial, Oliver G., Derendorf, Hartmut, Hillman, Jeffery D.   +3 more
openaire   +3 more sources

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, Volume 4, Issue 1, Page 82-93, February 2026.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Epidermin and gallidermin: Staphylococcal lantibiotics

International Journal of Medical Microbiology, 2014
The Staphylococcus epidermidis derived epidermin was the first lantibiotic that has been shown to be ribosomally synthesized and posttranslationally modified. Together with gallidermin, produced by Staphylococcus gallinarum, they belong to the large class of cationic antimicrobial peptides (CAMPs) that act against a broad spectrum of Gram-positive ...
Perconti, Silvana, Pope, Peter, Werner, Rolf, Schlag, Martin, Götz, Friedrich   +4 more
openaire   +3 more sources

Cationic Amphipathic Antimicrobial Peptides Perturb the Inner Membrane of Germinated Spores Thus Inhibiting Their Outgrowth

Frontiers in Microbiology, 2018
The mode of action of four cationic amphipathic antimicrobial peptides (AMPs) was evaluated against the non-pathogenic, Gram-positive, spore-forming bacterium, Bacillus subtilis. The AMPs were TC19, TC84, BP2, and the lantibiotic Nisin A.
Soraya Omardien, Jan Wouter Drijfhout, Sebastian A. Zaat, Stanley Brul   +3 more
doaj   +1 more source

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13. [PDF]

PLoS ONE, 2009
BACKGROUND: Lantibiotics are small microbial peptide antibiotics that are characterized by the presence of the thioether amino acids lanthionine and methyllanthionine. Lantibiotics possess structural genes which encode inactive prepeptides.
Jasmin Dischinger, Michaele Josten, Christiane Szekat, Hans-Georg Sahl, Gabriele Bierbaum   +4 more
doaj   +1 more source

An Integrated Engineering Approach to Creating Health‐Modulating Postbiotics

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Postbiotics have emerged as a promising alternative to live probiotics, offering comparable health benefits while overcoming challenges related to safety, stability, and shelf life. The review addresses current challenges in standardizing postbiotic definitions and production processes, and by outlining future research directions necessary to unlock ...
Michael Leonidas Chikindas, Diana E. Roopchand, Santosh Kumar Tiwari, Liubov S. Sichel, Mukund V. Karwe, Nitin Nitin, Vitor Luis Fagundes, Igor V. Popov, John R. Tagg, Xuanxuan Lu, Svetoslav Dimitrov Todorov   +10 more
wiley   +1 more source

Anthropogenic Disruption Versus Natural Restoration: Enterobacter cloacae‐Driven Barnacle Larval Settlement and Its Mitigation via Natural Bacteriophages

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
Anthropogenic‐derived E. cloacae colonises marine cooling water systems, where chlorine exposure drives cross‐resistance and enhances biofilm formation, creating hotspots for barnacle larval settlement. This work reveals a previously unrecognised mechanism linking microbial pollution to marine biofouling.
Atif Khan, Akash Saha, Hiren M. Joshi
wiley   +1 more source