Results 31 to 40 of about 2,586 (178)

Isolation and Analysis of the Nisin Biosynthesis Complex NisBTC: further Insights into Their Cooperative Action

mBio, 2021
Lantibiotics are ribosomally synthesized and posttranslationally modified peptide antibiotics. Although the membrane-associated lantibiotic biosynthesis machinery has long been proposed to exist, the isolation of such a complex has not been reported yet,
Jingqi Chen, Oscar P. Kuipers
doaj   +1 more source

Protein defence systems against the lantibiotic nisin: Function of the immunity protein NisI and the resistance protein NSR

Frontiers in Microbiology, 2016
Lantibiotics are potential alternatives to antibiotics because of their broad-range killing spectrum. The producer strain is immune against its own synthesized lantibiotic via the expression of two proteins LanI and LanFEG.
Sakshi eKhosa, Marcel eLagedroste, Sander Hj Smits   +2 more
doaj   +1 more source

The length of a lantibiotic hinge region has profound influence on antimicrobial activity and host specificity

Frontiers in Microbiology, 2015
Lantibiotics are ribosomally synthesized (methyl)lanthionine containing peptides which can efficiently inhibit the growth of Gram-positive bacteria. As lantibiotics kill bacteria efficiently and resistance to them is difficult to be obtained, they have ...
Liang eZhou, Auke L. evan Heel, Oscar P. Kuipers   +2 more
doaj   +1 more source

Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin

AMB Express, 2023
Keypoints Taxonomically distant species have a wide diversity of roseocin family lantibiotics. The phylogeny-guided approach opens new possibilities for RiPPs bioengineering.
Sandeep Chaudhary, Shweta Kishen, Mangal Singh, Sunanda Jassal, Reeva Pathania, Kalpana Bisht, Dipti Sareen   +6 more
doaj   +1 more source

Large Scale Production and Downstream Processing of Labyrinthopeptins from the Actinobacterium Actinomadura namibiensis

Bioengineering, 2018
A method was established for the production of 1.2-fold and 4.2-fold increased amounts of the antiviral and central nervous system-active lantipeptides, labyrinthopeptins A1 and A2, respectively, isolated from the actinobacterium Actinomadura namibiensis,
Zeljka Rupcic, Stephan Hüttel, Steffen Bernecker, Sae Kanaki, Marc Stadler   +4 more
doaj   +1 more source

Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance. [PDF]

PLoS ONE, 2016
Lantibiotics are antimicrobial peptides produced by Gram-positive bacteria. Interestingly, several clinically relevant and human pathogenic strains are inherently resistant towards lantibiotics.
Sakshi Khosa, Astrid Hoeppner, Holger Gohlke, Lutz Schmitt, Sander H J Smits   +4 more
doaj   +1 more source

Structure and Activity of Class II Lanthipeptides From a Thermophilic Bacterium

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Heterologous coexpression of the lanthipeptide synthetase TlaM from the thermophilic bacterium Thermoactinomyces sp. DSM 45891, with the precursor peptides TlaA1 and TlaA2 in Escherichia coli, resulted in the introduction of four thioether rings in both peptides.
Enleyona Weir, Lingyang Zhu, Wilfred A. van der Donk   +2 more
wiley   +1 more source

Genomic Insights Into Antimicrobial Resistance and Virulence of Enterococcus avium Strains From Bovine Mastitis in Some Selected Dairy Farms of Bangladesh

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
The graphical abstract outlines that samples from milk, faeces and soil were tested for Enterococcus avium using culture, PCR and genome sequencing.2. Overall, prevalence of E. avium was 56.3%, and 93.5% of isolates were multidrug‐resistant.3. Genomic analysis revealed six ARGs, 43–45 VFGs and 4–6 bacteriocins.4.
Monira Rahaman, Md. Morshedur Rahman, Kh. Yeashir Arafat, Md. Abu Ahsan Gilman, Naim Siddique, Taniya Sultana, Ziban Chandra Das, Anup Kumar Talukder, Tofazzal Islam, A. N. M. Aminoor Rahman, M. Nazmul Hoque   +10 more
wiley   +1 more source

Clinical experience of Streptococcus salivarius K12 use for the prevention of pharyngotonsillitis and respiratory infections in children

Zdorovʹe Rebenka, 2018
Background. Streptococcus salivarius K12 (SsK12) is an oral colonizing, persistent, antibiotic-sensitive and safe strain that produces two megaplasmid-encoded class I lantibiotics, namely salivaricin A2 and salivaricin B, which expression inhibits the ...
T.O. Kryuchko, O.Ya. Tkachenko
doaj   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq, Doni Dermawan, Samir Chtita   +2 more
wiley   +1 more source