Results 11 to 20 of about 2,586 (178)

Clinical Effects of Streptococcus salivarius K12 in Hospitalized COVID-19 Patients: Results of a Preliminary Study

Microorganisms, 2022
Anatomical and physiological considerations indicate that the oral cavity is a primary source of the lung microbiota community, and recent studies have shown that the microbiota in the lungs contributes to immunological homeostasis, potentially altering ...
Francesco Di Pierro, Somia Iqtadar, Sami Ullah Mumtaz, Alexander Bertuccioli, Martino Recchia, Nicola Zerbinati, Amjad Khan   +6 more
doaj   +1 more source

Combating Antimicrobial Resistance With New-To-Nature Lanthipeptides Created by Genetic Code Expansion

Frontiers in Microbiology, 2020
Due to the rapid emergence of multi-resistant bacterial strains in recent decades, the commercially available effective antibiotics are becoming increasingly limited.
Hamid Reza Karbalaei-Heidari, Hamid Reza Karbalaei-Heidari, Nediljko Budisa, Nediljko Budisa   +3 more
doaj   +1 more source

In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium

Microorganisms, 2021
Post-translationally modified, (methyl-)lanthionine-containing peptides are produced by several Gram-positive bacteria. These so-called lantibiotics have potent activity against various bacterial pathogens including multidrug-resistant strains and are ...
Oliver Goldbeck, Dominik Weixler, Bernhard J. Eikmanns, Christian U. Riedel   +3 more
doaj   +1 more source

Conjugation of Synthetic Polyproline Moietes to Lipid II Binding Fragments of Nisin Yields Active and Stable Antimicrobials

Frontiers in Microbiology, 2020
Coupling functional moieties to lantibiotics offers exciting opportunities to produce novel derivatives with desirable properties enabling new functions and applications.
Jingjing Deng, Jakob H. Viel, Vladimir Kubyshkin, Vladimir Kubyshkin, Nediljko Budisa, Nediljko Budisa, Oscar P. Kuipers   +6 more
doaj   +1 more source

Insights in the Antimicrobial Potential of the Natural Nisin Variant Nisin H

Frontiers in Microbiology, 2020
Lantibiotics are a growing class of antimicrobial peptides, which possess antimicrobial activity against mainly Gram-positive bacteria including the highly resistant strains such as methicillin-resistant Staphylococcus aureus or vancomycin-resistant ...
Jens Reiners, Jens Reiners, Marcel Lagedroste, Julia Gottstein, Emmanuel T. Adeniyi, Rainer Kalscheuer, Gereon Poschmann, Kai Stühler, Kai Stühler, Sander H. J. Smits, Sander H. J. Smits, Lutz Schmitt   +11 more
doaj   +1 more source

Potentiating the activity of nisin against Escherichia coli

Frontiers in Cell and Developmental Biology, 2016
Lantibiotics are antimicrobial (methyl) lanthionine-containing peptides produced by various Gram-positive bacteria. The model lantibiotic, nisin, binds lipid II in the cell membrane.
Liang eZhou, Auke J. van Heel, Manuel eMontalban-Lopez, Oscar P. Kuipers   +3 more
doaj   +1 more source

The N-terminal Region of Nisin Is Important for the BceAB-Type ABC Transporter NsrFP from Streptococcus agalactiae COH1

Frontiers in Microbiology, 2017
Lantibiotics are (methyl)-lanthionine-containing antimicrobial peptides produced by several Gram-positive bacteria. Some human pathogenic bacteria express specific resistance proteins that counteract this antimicrobial activity of lantibiotics.
Jens Reiners, Marcel Lagedroste, Katja Ehlen, Selina Leusch, Julia Zaschke-Kriesche, Sander H. J. Smits   +5 more
doaj   +1 more source

Subcellular Localization and Assembly Process of the Nisin Biosynthesis Machinery in Lactococcus lactis

mBio, 2020
Nisin, a class I lantibiotic, is synthesized as a precursor peptide by a putative membrane-associated lanthionine synthetase complex consisting of the dehydratase NisB, the cyclase NisC, and the ABC transporter NisT. Here, we characterize the subcellular
Jingqi Chen, Auke J. van Heel, Oscar P. Kuipers   +2 more
doaj   +1 more source

Microbisporicin (NAI-107) protects Galleria mellonella from infection with Neisseria gonorrhoeae

Microbiology Spectrum, 2023
Due to the increasing incidence of antibiotic-resistant bacterial pathogens, the need for the development of alternative compounds is of utmost importance. Bacteriocins are considered a promising alternative to antibiotics.
Nele Hofkens, Zina Gestels, Said Abdellati, Irith De Baetselier, Philippe Gabant, Anandi Martin, Christopher Kenyon, Sheeba Santhini Manoharan-Basil   +7 more
doaj   +1 more source

Kunkecin A, a New Nisin Variant Bacteriocin Produced by the Fructophilic Lactic Acid Bacterium, Apilactobacillus kunkeei FF30-6 Isolated From Honey Bees

Frontiers in Microbiology, 2020
Apilactobacillus kunkeei FF30-6 isolated from healthy honey bees synthesizes the bacteriocin, which exhibits antimicrobial activity against Melissococcus plutonius.
Takeshi Zendo, Chihiro Ohashi, Shintaro Maeno, Xingguo Piao, Seppo Salminen, Kenji Sonomoto, Akihito Endo   +6 more
doaj   +1 more source