Results 21 to 30 of about 2,586 (178)

Lantibiotic Structures as Guidelines for the Design of Peptides That Can Be Modified by Lantibiotic Enzymes [PDF]

Biochemistry, 2005
Lantibiotics are (methyl)lanthionine-containing bacterial peptides. (Methyl)lanthionines are posttranslationally introduced into the prepropeptides by biosynthetic enzymes that dehydrate serines and threonines and couple these dehydrated residues to cysteine residues. Thirty seven lantibiotic primary structures have been proposed to date, but little is
Rink, R, Kuipers, A, de Boef, E, Leenhouts, KJ, Driessen, AJM, Moll, GN, Kuipers, OP, Leenhouts, Kees J.   +7 more
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Design and Expression of Specific Hybrid Lantibiotics Active Against Pathogenic Clostridium spp.

Frontiers in Microbiology, 2019
Clostridium difficile has been reported as the most common cause of nosocomial diarrhea (antibiotic-associated diarrhea), resulting in significant morbidity and mortality in hospitalized patients.
Rubén Cebrián, Alicia Macia-Valero, Afif P. Jati, Oscar P. Kuipers   +3 more
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Diverse Bacteriocins Produced by Strains From the Human Milk Microbiota

Frontiers in Microbiology, 2020
Microbial colonization of the infant gut is a convoluted process dependent on numerous contributing factors, including age, mode of delivery and diet among others that has lifelong implication for human health.
Angeliki Angelopoulou, Angeliki Angelopoulou, Alicja K. Warda, Paula M. O’Connor, Paula M. O’Connor, Stephen R. Stockdale, Andrey N. Shkoporov, Des Field, Des Field, Lorraine A. Draper, Catherine Stanton, Catherine Stanton, Colin Hill, Colin Hill, R. Paul Ross, R. Paul Ross, R. Paul Ross   +16 more
doaj   +1 more source

Evaluation of analogs of mutacin 1140 in systemic and cutaneous methicillin-resistant Staphylococcus aureus infection models in mice

Frontiers in Microbiology, 2022
Mutacin 1140 (Mu1140) is a potent antibiotic against Gram-positive bacteria, such as Staphylococcus aureus. The antibiotic is produced by the oral bacterium Streptococcus mutans and is a member of the epidermin family of type AI lantibiotics.
Min Ju, Thushinari Joseph, Nopakorn Hansanant, Mengxin Geng, McKinley Williams, Andrew Cothrell, Andrew Riley Buhrow, Andrew Riley Buhrow, Frank Austin, Leif Smith, Leif Smith   +10 more
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Lantibiotics as probes for phosphatidylethanolamine [PDF]

Amino Acids, 2009
Phosphatidylethanolamine (PE) is a major component in the mammalian plasma membrane. It is present mainly in the inner leaflet of the membrane bilayer in a viable, typical mammalian cell. However, accumulating evidence indicates that a number of biological events involve PE externalization.
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Quorum sensing in group A streptococcus

Frontiers in Cellular and Infection Microbiology, 2014
Quorum sensing is a widespread phenomenon in the microbial world that has important implications in the coordination of population-wide responses in several bacterial pathogens.
Michael J. Federle, Juan Cristobal Jimenez   +1 more
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Bioengineering of the model lantibiotic nisin [PDF]

Bioengineered, 2015
The lantibiotics are a class of bacterially produced antimicrobial peptides (bacteriocins) that contain several unusual amino acids resulting from enzyme-mediated post-translational modifications. They exhibit high specific activity against Gram-positive targets, including many antibiotic-resistant pathogens, and consequently have been investigated ...
Des, Field, Paul D, Cotter, R Paul, Ross, Colin, Hill   +3 more
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Tonsillar Microbiome‐Derived Lantibiotics Induce Structural Changes of IL‐6 and IL‐21 Receptors and Modulate Host Immunity

Advanced Science, 2022
Emerging evidence emphasizes the functional impacts of host microbiome on the etiopathogenesis of autoimmune diseases, including rheumatoid arthritis (RA).
Jing Li, Jiayang Jin, Shenghui Li, Yan Zhong, Yuebo Jin, Xuan Zhang, Binbin Xia, Yinhua Zhu, Ruochun Guo, Xiaolin Sun, Jianping Guo, Fanlei Hu, Wenjing Xiao, Fei Huang, Hua Ye, Ru Li, Yunshan Zhou, Xiaohong Xiang, Haihong Yao, Qiulong Yan, Li Su, Lijun Wu, Tuoping Luo, Yudong Liu, Xiaohuan Guo, Junjie Qin, Hai Qi, Jing He, Jun Wang, Zhanguo Li   +29 more
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The Lantibiotic Mersacidin Is an Autoinducing Peptide [PDF]

Applied and Environmental Microbiology, 2006
ABSTRACT The lantibiotic (lanthionine-containing antibiotic) mersacidin is an antimicrobial peptide consisting of 20 amino acids and is produced by Bacillus sp. strain HIL Y-85,54728. The structural gene ( mrsA ) and the genes for producer self-protection, modification enzymes ...
Stephanie, Schmitz, Anja, Hoffmann, Christiane, Szekat, Brian, Rudd, Gabriele, Bierbaum   +4 more
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Genome-Guided Mass Spectrometry Expedited the Discovery of Paraplantaricin TC318, a Lantibiotic Produced by Lactobacillus paraplantarum Strain Isolated From Cheese

Frontiers in Microbiology, 2020
The quest for potent alternatives to the currently used antimicrobials is urged by health professionals, considering the rapid rise in resistance to preservatives and antibiotics among pathogens.
Walaa E. Hussein, Walaa E. Hussein, En Huang, Ismet Ozturk, Árpád Somogyi, Xu Yang, Baosheng Liu, Ahmed E. Yousef, Ahmed E. Yousef   +8 more
doaj   +1 more source