Results 1 to 10 of about 2,586 (178)
Bioengineering Lantibiotics for Therapeutic Success [PDF]
Frontiers in Microbiology, 2015 Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesised equivalents are being discovered with increased frequency.
Paul Cotter, Colin Hill, Des Field
exaly +6 more sources
Synthesis of a Novel Lantibiotic Using Mutacin II Biosynthesis Apparatus [PDF]
Microbiology Spectrum, 2023 Owing to extensive metagenomic studies, we now have access to numerous sequences of novel bacteriocin-like antimicrobial peptides encoded by various cultivable and noncultivable bacteria.
Saswati Biswas
doaj +2 more sources
From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity. [PDF]
SmallAntimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Rossetti P +5 more
europepmc +2 more sources
Structural insights into the substrate binding mechanism of the class I dehydratase MadB [PDF]
Communications BiologyIn the battle against antimicrobial resistance, lantibiotics have emerged as promising new sources for antimicrobial drugs. Their exceptional stability is due to characteristic modifications termed (methyl-)lanthionine rings.
C. Vivien Knospe +6 more
doaj +2 more sources
Listeria monocytogenes-Can We Reduce or Eliminate It From Food Commodities? [PDF]
Mol Nutr Food ResListeria monocytogenes is a foodborne pathogen responsible for listeriosis. Traditional control methods include heat treatment, high‐pressure processing, irradiation, and acidification, all aimed at reducing bacterial load in foods. Emerging strategies include gene expression, CRISPR‐Cas9, bacteriophage, competitive exclusion via beneficial microbes ...
d'Ovidio L +5 more
europepmc +2 more sources
Bovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge. [PDF]
PLoS ONE, 2014 Lantibiotics are ribosomally-synthesized and posttranslationally modified peptides with potent antimicrobial activities. Discovery of novel lantibiotics has been greatly accelerated with the soaring release of genomic information of microorganisms.
Jian Wang +6 more
doaj +1 more source
Frontiers in Microbiology, 2023 The rapid emergence of microbial multi-resistance against antibiotics has led to intense search for alternatives. One of these alternatives are ribosomally synthesized and post-translationally modified peptides (RiPPs), especially lantibiotics.
C. Vivien Knospe +9 more
doaj +1 more source
Micromachines, 2021 Lanthionine-containing peptides (lantibiotics) have been considered as pharmaceutical candidates for decades, although their clinical application has been restricted.
Irina Panina +3 more
doaj +1 more source
Engineering of Nisin as a Means for Improvement of Its Pharmacological Properties: A Review
Pharmaceuticals, 2023 Lantibiotics are believed to have a conceivable potential to be used as therapeutics, especially against clinically resistant bacterial strains. However, their low solubility and poor stability under physiological conditions limit their availability for ...
Mateusz Musiejuk, Paweł Kafarski
doaj +1 more source
Microbiology and Molecular Biology Reviews, 2015 SUMMARY The dramatic rise in the incidence of antibiotic resistance demands that new therapeutic options will have to be developed. One potentially interesting class of antimicrobials are the modified bacteriocins termed lantibiotics, which are bacterially produced, posttranslationally modified, lanthionine/methyllanthionine-containing ...
Lorraine A, Draper +3 more
openaire +2 more sources