Results 61 to 70 of about 2,586 (178)

Bacteriocins as a Promising Antimicrobial Strategy Against Multidrug‐Resistant Pathogens: Mechanisms of Action, Applications in Human and Animal Health, and the Food Industry

BioMed Research International, Volume 2026, Issue 1, 2026.
The global rise of antimicrobial resistance has significantly increased the difficulty treating infectious agents, creating an urgent need for alternative therapeutic strategies. In this context, bacteriocins have emerged as a promising solution, offering a potential alternative to conventional antibacterial therapies.
Abdo Megra Geda, Aregash Wendimu Tumebo, Solomon Lulie Abey, Gashaw Enbiyale Kasse, Abraham Belete Temesgen, Zerihun Getie Wassie, Baisakhi Banerjee   +6 more
wiley   +1 more source

Lantibiotics as prospective antimycobacterial agents [PDF]

Bioengineered Bugs, 2010
Mycobacteria contribute substantially to human infectious disease, most notably the primary pathogens of tuberculosis (TB), leprosy and Bureli ulcer. Global prospects for TB control are challenged by the emergence of drug-resistant strains. If we are to stay ahead of mycobacterial strains developing resistance to chemotherapeutic regimens, all new ...
openaire   +2 more sources

SppI Forms a Membrane Protein Complex with SppA and Inhibits Its Protease Activity in Bacillus subtilis

mSphere, 2020
The membrane protease SppA of Bacillus subtilis was first described as a signal peptide peptidase and later shown to confer resistance to lantibiotics. Here, we report that SppA forms octameric complexes with YteJ, a membrane protein of thus-far-unknown ...
Gabriela Henriques, Stephen McGovern, Jolanda Neef, Minia Antelo-Varela, Friedrich Götz, Andreas Otto, Dörte Becher, Jan Maarten van Dijl, Matthieu Jules, Olivier Delumeau   +9 more
doaj   +1 more source

Isolation, Characterization, and Optimization of Antimicrobial Proteinaceous Compounds Produced by Bacillus safensis Isolated From Rhizosphere Soil Samples in Bangladesh

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Bacillus species are widely distributed in nature and are recognized for their capacity to synthesize a wide range of antimicrobial compounds effective against multidrug‐resistant bacterial and fungal pathogens, highlighting their potential as alternatives to conventional antibiotics. This study focused on the isolation of Bacillus spp.
Fatema Tuz Jubyda, Mohammed Ayaz, Shyama Prosad Moulick, Firoz Ahmed, Md. Anowar Khasru Parvez, Shweta Negi   +5 more
wiley   +1 more source

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria

BMC Genomics, 2010
Background Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents.
Ross R Paul, O'Sullivan Orla, Marsh Alan J, Cotter Paul D, Hill Colin   +4 more
doaj   +1 more source

Integration of In Vitro Approaches With Whole‐Genome Sequencing to Evaluate the Probiotic Potential of Lactic Acid Bacteria Isolated From Thit Chua: A Traditional Fermented Sour Meat in Northwest Vietnam

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Human demand for safe and high‐quality fermented meat products has been increasing, emphasizing the need to develop innovative production approaches that incorporate functional starter cultures. This study investigated the biodiversity of culturable lactic acid bacteria (LAB) in thit chua, a traditional fermented pork meat locally produced by the Muong
Nhung Thi Doan, Ha Viet Nguyen, Huy Duc Bui, Van Thi Nguyen, Linh Hai Nguyen Bui, Lan Anh Thi Hoang, Trung Thanh Trinh, Giuseppe Comi   +7 more
wiley   +1 more source

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity

Beilstein Journal of Organic Chemistry
Antimicrobial resistance presents a substantial threat to global public health, demanding urgent attention and action. This study focuses on lanthipeptides, ribosomally encoded peptides that display significant structural diversity and hold promising ...
Moisés Alejandro Alejo Hernandez, Katia Pamela Villavicencio Sánchez, Rosendo Sánchez Morales, Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez, Eddie Guillermo Sanchez-Rueda, Yanet Teresa-Cruz, Brian Choi, Armando Hernández Garcia, Alba Romero-Rodríguez, Oscar Juárez, Siseth Martínez-Caballero, Mario Figueroa, Corina-Diana Ceapă   +13 more
doaj   +1 more source

Salivaricin G32, a Homolog of the Prototype Streptococcus pyogenes Nisin-Like Lantibiotic SA-FF22, Produced by the Commensal Species Streptococcus salivarius

International Journal of Microbiology, 2012
Salivaricin G32, a 2667 Da novel member of the SA-FF22 cluster of lantibiotics, has been purified and characterized from Streptococcus salivarius strain G32.
Philip A. Wescombe, Kristin H. Dyet, Karen P. Dierksen, Daniel A. Power, Ralph W. Jack, Jeremy P. Burton, Megan A. Inglis, Anna L. Wescombe, John R. Tagg   +8 more
doaj   +1 more source

Fracturing Rings to Understand Lantibiotics

Chemistry & Biology, 2008
Haloduracin is a bacterially produced antibiotic system of two alkali-stable peptides (Halalpha and Halbeta) that have extensive posttranslational modifications, including lanthionine rings. Now, Cooper et al. (2008) revise the structure of Halbeta and demonstrate that some of the lanthionine rings are not essential for bioactivity.
Yoganathan, Sabesan, Vederas, John C.
openaire   +2 more sources

Specificity and Application of the Lantibiotic Protease NisP

Frontiers in Microbiology, 2018
Lantibiotics are ribosomally produced and posttranslationally modified peptides containing several lanthionine residues. They exhibit substantial antimicrobial activity against Gram-positive bacteria, including relevant pathogens.
Manuel Montalbán-López, Jingjing Deng, Auke J. van Heel, Oscar P. Kuipers   +3 more
doaj   +1 more source