Results 51 to 60 of about 16,901 (224)

Protease inhibitors targeting coronavirus and filovirus entry. [PDF]

, 2015
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet, Barnard, Dale, Carrion, Ricardo, Lu, Kai, McKerrow, James H, Nunneley, Jerritt W, Pöhlmann, Stefan, Renslo, Adam R, Simmons, Graham, Vedantham, Punitha, Zhou, Yanchen   +10 more
core   +1 more source

Research Direction and Science Evaluation: The Role of Coherence and Alignment

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT The decisions of funding agencies greatly influence the direction of scientific research; however, our understanding of how applicants' research directions affect the selection process remains limited. In this study, we investigate how a project's coherence with a scientist's previous work and its alignment with current scientific trends ...
Charles Ayoubi, Sandra Barbosu, Michele Pezzoni, Fabiana Visentin   +3 more
wiley   +1 more source

From Lake Victoria to the Tap: Antibiotic Resistance and Pathogenic Contamination of Kisumu City Water Supply and Wastewater Network

Tropical Medicine &International Health, EarlyView.
ABSTRACT Waterborne diseases and antimicrobial resistance (AMR) pose mounting public health threats across sub‐Saharan Africa, particularly in rapidly urbanising regions dependent on untreated or poorly treated surface waters. This study applied shotgun metagenomic sequencing to characterise microbial communities, virulence factors and antibiotic ...
Oleg N. Reva, Anthony Sifuna, Francis Orata, Caroline Omolo, Jacob Stanley Iramiot, Mark C. Enright, Awelani Mutshembele, Jian Zhou, William A. Shivoga   +8 more
wiley   +1 more source

Lassa antiviral LHF-535 protects guinea pigs from lethal challenge

Scientific Reports, 2022
LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates significant morbidity and mortality.
Kathleen A. Cashman, Eric R. Wilkinson, Jeffrey Posakony, Ikenna G. Madu, Eric J. Tarcha, Kurt H. Lustig, Marcus J. Korth, Kristin M. Bedard, Sean M. Amberg   +8 more
doaj   +1 more source

Pathogens that Cause Illness Clinically Indistinguishable from Lassa Fever, Nigeria, 2018

Emerging Infectious Diseases, 2022
During the 2018 Lassa fever outbreak in Nigeria, samples from patients with suspected Lassa fever but negative Lassa virus PCR results were processed through custom gene expression array cards and metagenomic sequencing.
Jonathan W. Ashcroft, Adebola Olayinka, Nnaemeka Ndodo, Kuiama Lewandowski, Martin D. Curran, Chioma Dan Nwafor, Kingsley Madubuike, Helen Bagnall, Abdulmajid S. Musa, Adama Ahmad, Afolabi Akinpelu, Adesola Adeleye, Chukwuji Martin, Adejoke Akano, Michael Onoja, Akanimo Iniobong, Winifred Ukponu, Chinedu Arinze, Else Ilori, Nwando Mba, Benedict Gannon, Anthony Ahumibe, Chikwe Ihekweazu   +22 more
doaj   +1 more source

Epidemiology of Four Major Canine Tumours in the UK: Insights From a National Pathology Registry With Comparative Oncology Perspectives

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Pet dogs with naturally occurring cancers provide valuable models for comparative oncology and pathology tumour registries offer a powerful resource for onco‐epidemiological research. Here, we analysed the Small Animal Veterinary Surveillance Network (SAVSNET) pathology‐based tumour registry (PTR), one of the largest veterinary tumour ...
José Rodríguez, Antonio Espinosa de los Monteros, Ángelo Santana, P. J. Noble, Alan D. Radford, Francesco Cian, Annika Herrmann, Jenny S. McKay, Matthew Jones, David R. Killick   +9 more
wiley   +1 more source

Fractional Order Epidemic System of Saturated Rate of Incidence: A Neural Network Approach

Engineering Reports, Volume 8, Issue 3, March 2026.
The workflow depictions of the mathematical fractional order saturated rate of incidence model using the process of Levenberg–Marquardt Backpropagation neural network. The designed neural network contains 20 numbers of neurons, a sigmoid activation function, and a single hidden layer structure.
Zulqurnain Sabir, M. A. Abdelkawy, Muhammad Umar, Soheil Salahshour   +3 more
wiley   +1 more source

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs

Human Vaccines & Immunotherapeutics, 2017
We previously developed optimized DNA vaccines against both Lassa fever and Ebola hemorrhagic fever viruses and demonstrated that they were protective individually in guinea pig and nonhuman primate models.
Kathleen A. Cashman, Eric R. Wilkinson, Suzanne E. Wollen, Joshua D. Shamblin, Justine M. Zelko, Jeremy J. Bearss, Xiankun Zeng, Kate E. Broderick, Connie S. Schmaljohn   +8 more
doaj   +1 more source

Current Trends of Lassa fever amidst COVID-19 Pandemic in Nigeria

Global Biosecurity, 2023
Lassa fever is a disease endemic in West Africa caused by the Lassa virus (LASV). The emergence of the COVID-19 pandemic has put an extra burden on Nigeria in the fight against infectious disease outbreaks.
Jeremiah Oluwamayowa Omojuyigbe, Habeebullah Jayeola Oladipo, Moriam Adesola Adegbite, Yusuf Babatunde, Taiwo Oluwaseun Sokunbi, Oluwakorede Adedeji, Ibrahim Abdulmumin   +6 more
doaj   +1 more source

Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. [PDF]

, 2018
During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women.
Aagaard, Kjersti M, Castro, Eumenia CC, Chiu, Charles Y, Giavedoni, Luis, Hodara, Vida L, Layne-Colon, Donna, Li, Tony, Martyn, Calla, Parodi, Laura M, Patterson, Jean L, Reyes, Kevin, Rutherford, Julienne, Seferovic, Maxim, Suter, Melissa A, Sánchez-San Martín, Claudia, Tamhankar, Manasi, Tardif, Suzette D, Yagi, Shigeo   +17 more
core   +2 more sources