Results 91 to 100 of about 1,759,457 (222)

The crosstalk between ubiquitination and GlcNAcylation of CHAF1A regulates HIV-1 latency and reactivation

Journal of Virology
The persistence of latent HIV-1 reservoirs remains a critical barrier to cure. Current “shock and kill” strategies are limited by ineffective latency-reversing agents (LRAs) and poor understanding of epigenetic regulation.
Tao Yang, Minghua Chen, Mo Zhou, Xiaohui Deng, Peiming Huang, Siyi Xie, Jianteng Zeng, Jingjing Luo, Yiwen Zhang, Xiancai Ma, Liqin Sun, Jiaye Liu, Hui Zhang, Linghua Li, Bingfeng Liu, Jie Qin, Ting Pan   +16 more
doaj   +1 more source

Design and Modeling of a High‐Displacement, Skin‐Integrated Flexible Electromagnetic Actuator for Haptic Interfaces in Virtual Reality

Advanced Robotics Research, EarlyView.
A flexible, skin‐integrated electromagnetic actuator is developed for wearable virtual/augmented reality (VR/AR) haptic systems. A tunable design model enables control over displacement and resonance frequency. The system is validated through a custom VR application with a 6 × 4 actuator array, demonstrating real‐time, spatially targeted tactile ...
Naji Tarabay, Alexandra Zhang Jiang, Ziteng Liu, Rachel Villamor, Derek Cha, Ananya Renuka Balakrishna, Tianshu Liu, Priyanshu Agarwal, Rainer Dömer, Camilo Velez   +9 more
wiley   +1 more source

Latency reversing agents affect HIV RNA splicing [PDF]

, 2017
© 2017 Dr. Talia Monique MotaAlthough antiretroviral therapy (ART) has changed HIV from a death sentence to a manageable chronic illness, there is still no cure and individuals living with HIV must endure lifelong therapy and continue to face stigma and ...
Mota, Talia Monique
core   +1 more source

Protocol for intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4+ T cell model

STAR Protocols
Summary: Investigating the molecular mechanisms of HIV latency reversal in a proper physiological context can only be done in primary cells. Here, we describe a primary T cell model of HIV latency and a reliable flow cytometry assay to measure latency ...
Uri Mbonye, Anna Agaponova, Muda Yang, Jonathan Karn   +3 more
doaj   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Targeting Viral Transcription for HIV Cure Strategies

Microorganisms
Combination antiretroviral therapy (ART) suppresses viral replication to undetectable levels, reduces mortality and morbidity, and improves the quality of life of people living with HIV (PWH).
Jon Izquierdo-Pujol, Maria C. Puertas, Javier Martinez-Picado, Sara Morón-López   +3 more
doaj   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

OP 2.8 – 00193 Enhancing PKC Modulator HIV Latency Reversing Agents

Journal of Virus Eradication, 2022
M. Marsden, J. Moran, V. Pham, J. Kim, P. Wender, J. Zack   +5 more
doaj   +1 more source