Results 91 to 100 of about 9,787 (247)

A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis

Virology Journal
Background Although macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and reactivated in these cell types is poorly understood.
Javan K. Kisaka, Daniel Rauch, Malachi Griffith, George B. Kyei   +3 more
doaj   +1 more source

Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency

EMBO Molecular Medicine, 2017
Highly active antiretroviral therapy (HAART) has improved the outlook for the HIV epidemic, but does not provide a cure. The proposed “shock‐and‐kill” strategy is directed at inducing latent HIV reservoirs, which may then be purged via boosted immune ...
Pargol Hashemi, Kris Barreto, Wendy Bernhard, Adam Lomness, Nicolette Honson, Tom A Pfeifer, P Richard Harrigan, Ivan Sadowski   +7 more
doaj   +1 more source

PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent - Supplementary dataset

, 2023
Aim: To investigate Prussian blue nanoparticles (PBNPs) coated with the synthetic analog of dsRNA polyinosinic-polycytidylic acid (polyIC) for their ability to function as HIV latency reversing agents.
Preethi B Balakrishnan (14563084), Carissa S Holmberg (14563086), Debbie K Ledezma (14563087), Alberto Bosque (202328), Rohan Fernandes (1438021)   +4 more
core   +1 more source

Compliant Pneumatic Feet with Real‐Time Stiffness Adaptation for Humanoid Locomotion

Advanced Robotics Research, EarlyView.
A compliant pneumatic foot with real‐time variable stiffness enables humanoid robots to adapt to changing terrains. Using onboard vision and pressure control, the foot modulates stiffness within each gait cycle, reducing impact forces and improving balance. The design, cast in soft silicone with embedded air chambers and Kevlar wrapping, offers durable,
Irene Frizza, Hiroshi Kaminaga, Philippe Fraisse, Gentiane Venture   +3 more
wiley   +1 more source

Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab

Nature Communications, 2019
Here, the authors identify B lymphocyte antigen CD20 as a marker for HIV-infected T cells and provide evidence for the potential use of anti-CD20 antibodies in combination with latency reversing agents for depletion of viral reactivated CD4 T cells in ...
Carla Serra-Peinado, Judith Grau-Expósito, Laura Luque-Ballesteros, Antonio Astorga-Gamaza, Jordi Navarro, Jenny Gallego-Rodriguez, Mario Martin, Adrià Curran, Joaquin Burgos, Esteban Ribera, Berta Raventós, Rein Willekens, Ariadna Torrella, Bibiana Planas, Rosa Badía, Felipe Garcia, Josep Castellví, Meritxell Genescà, Vicenç Falcó, Maria J. Buzon   +19 more
doaj   +1 more source

Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents

Open Forum Infectious Diseases, 2016
AbstractIn chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or control this reservoir are now being pursued in the clinic. These strategies include latency reversal agents (LRAs) designed to
Delagreverie, HM, Delaugerre, C, Lewin, SR, Deeks, SG, Li, JZ   +4 more
openaire   +5 more sources

Miniaturized Magnetic Tip Design for Endoluminal Vine Robot Navigation

Advanced Robotics Research, EarlyView.
A magnetic tip mount is designed for a miniaturized 7 mm soft‐growing vine robot to enable wireless magnetic steering and onboard imaging, while preserving a 3 mm working channel. The internal–external ring magnets design balances magnetic attachment with low eversion pressure. Experiments demonstrate ±90° steering, 34 mm bending radius, and successful
Andrea Yanez Trujillo, Joshua Davy, James H. Chandler, James Avery, Pietro Valdastri   +4 more
wiley   +1 more source

Broad activation of latent HIV-1 in vivo

Nature Communications, 2016
Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and ...
Kirston Barton, Bonnie Hiener, Anni Winckelmann, Thomas Aagaard Rasmussen, Wei Shao, Karen Byth, Robert Lanfear, Ajantha Solomon, James McMahon, Sean Harrington, Maria Buzon, Mathias Lichterfeld, Paul W. Denton, Rikke Olesen, Lars Østergaard, Martin Tolstrup, Sharon R. Lewin, Ole Schmeltz Søgaard, Sarah Palmer   +18 more
doaj   +1 more source

Global Dynamics of the HIV Latent Reservoir with Latency Reversing Agents and Immune Response

, 2020
In this project, we model the dynamics of HIV-1 latently infected cells under the effects of latency reversing agents (LRAs) to promote a natural immune response. We establish the existence of immune-free and positive equilibria and then utilize Lyapunov
Berchtold, Claire, Mitchum, Hannah
core  

Design and Modeling of a High‐Displacement, Skin‐Integrated Flexible Electromagnetic Actuator for Haptic Interfaces in Virtual Reality

Advanced Robotics Research, EarlyView.
A flexible, skin‐integrated electromagnetic actuator is developed for wearable virtual/augmented reality (VR/AR) haptic systems. A tunable design model enables control over displacement and resonance frequency. The system is validated through a custom VR application with a 6 × 4 actuator array, demonstrating real‐time, spatially targeted tactile ...
Naji Tarabay, Alexandra Zhang Jiang, Ziteng Liu, Rachel Villamor, Derek Cha, Ananya Renuka Balakrishna, Tianshu Liu, Priyanshu Agarwal, Rainer Dömer, Camilo Velez   +9 more
wiley   +1 more source