Results 101 to 110 of about 9,787 (247)

TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

eLife, 2019
Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure.
Xiancai Ma, Tao Yang, Yuewen Luo, Liyang Wu, Yawen Jiang, Zheng Song, Ting Pan, Bingfeng Liu, Guangyan Liu, Jun Liu, Fei Yu, Zhangping He, Wanying Zhang, Jinyu Yang, Liting Liang, Yuanjun Guan, Xu Zhang, Linghua Li, Weiping Cai, Xiaoping Tang, Song Gao, Kai Deng, Hui Zhang   +22 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

, 2016
Despite the success of combination antiretroviral therapy (cART), HIV persists in long lived latently infected cells in the blood and tissue, and treatment is required lifelong.
Gray, LR, Wesselingh, SL, Ellett, AM, Cheng, W., Roberts, E., Lewin, SR, Jacobson, J., Raison, JA, Gorry, PR, Purcell, D., Lu, HK, Churchill, M., Purcell, DFJ, Moso, MA, Jacobson, JC, Gray, L., Ellett, A., Wesselingh, S., On, H., Gorry, P., Cheng, WJ, Lewin, S., Moso, M., Papaioannou, C., Churchill, MJ, Lu, H., Papaioannou, C, Raison, J., Roberts, E, On, H   +29 more
core   +2 more sources

Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir [PDF]

, 2016
Objective: HIV-1 reservoirs are the major hurdle to virus clearance in combination antiretroviral therapy (cART)-Treated patients. An approach to eradicating HIV-1 involves reversing latency in cART-Treated patients to make latent cells visible to the ...
De Wit, S, Rohr, O, Rohr, O. (Olivier), Van Lint, C. (Carine), De Wit, S. (Stéphane), Van Lint, Carine, Darcis, Gilles, De Wit, Stéphane, Rouzioux, C, Vanhulle, C. (Caroline), Bouchat, S, Kula, Anna, Delacourt, Nadège, Bouchat, S. (Sophie), Vanhulle, Caroline, Delacourt, N, Rouzioux, C. (Christine), Darcis, G. (Gilles), Rohr, Olivier, Rouzioux, Christine, Van Driessche, Benoît, Avettand-Fenoel, Veronique, Vanhulle, C, Avettand-Fenoel, V. (Véronique), Van Driessche, B, Delacourt, N. (Nadège), Bouchat, Sophie, Van Driessche, B. (Benoit), Kula, A. (Anna)   +28 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Latency reversing agents affect HIV RNA splicing [PDF]

, 2017
© 2017 Dr. Talia Monique MotaAlthough antiretroviral therapy (ART) has changed HIV from a death sentence to a manageable chronic illness, there is still no cure and individuals living with HIV must endure lifelong therapy and continue to face stigma and ...
Mota, Talia Monique
core  

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat.

, 2015
The pharmaceutical reactivation of dormant HIV-1 proviruses by histone deacetylase inhibitors (HDACi) represents a possible strategy to reduce the reservoir of HIV-1-infected cells in individuals treated with suppressive combination antiretroviral ...
Carrington, M., Bashirova, A., Vigano, S., Rasmussen, T.A., Østergaard, L., Søgaard, O.S., Buzon, M., Olesen, R., Yu, X.G., Tolstrup, M., Palmer, S., Brinkmann, C.R., Ouyang, Z., Lichterfeld, M.   +13 more
core   +1 more source

The role of latency reversal in HIV cure strategies

, 2022
One strategy to eliminate latently infected cells that persist in people with HIV on antiretroviral therapy is to activate virus transcription and virus production to induce virus or immune‐mediated cell death. This is called latency reversal.
Kim, Y, Lewin, Sharon R., Roche, Michael, Lewin, SR, Tanaka, Kiho, Tanaka, K, Roche, M, Kim, Youry   +7 more
core   +1 more source