Results 51 to 60 of about 9,787 (247)
Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure
Molecular Therapy: Nucleic Acids, 2021 The advent of antiretroviral therapy almost 25 years ago has transformed HIV-1 infection into a manageable chronic condition, albeit still incurable. The inability of the treatment regimen to eliminate latently infected cells that harbor the virus in an ...
Saikat Boliar, David G. Russell
doaj +1 more source
De Novo synthesis of VP16 coordinates the exit from HSV latency in vivo [PDF]
, 2009 The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade
Sawtell, N.M. +5 more
core +1 more source
Engineering CAR T Cells to Target the HIV Reservoir
Frontiers in Cellular and Infection Microbiology, 2020 The HIV reservoir remains to be a difficult barrier to overcome in order to achieve a therapeutic cure for HIV. Several strategies have been developed to purge the reservoir, including the “kick and kill” approach, which is based on the notion that ...
Wenli Mu +2 more
doaj +1 more source
Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling
, 2017 International audienceIn this study, we looked for a new family of latency reversing ...
Campos, Noëlie +29 more
core +1 more source
Novel Triazolopyridine-Based BRD4 Inhibitors as Potent HIV‑1 Latency Reversing Agents
, 2023 Bromodomain-containing protein 4 (BRD4) inhibitors have been proven to be a promising option for anti-HIV-1 latency therapeutics. We herein describe the design, synthesis, and anti-HIV-1 latency bioevaluation of triazolopyridine derivatives as BRD4 ...
Zhi-Yu Li (7008698) +13 more
core +1 more source
Frontiers in Microbiology, 2018 Identifying the source and dynamics of persistent HIV-1 at single-cell resolution during cART is crucial for the design of strategies to eliminate the latent HIV-1 reservoir.
Wang Zhang +5 more
doaj +1 more source
The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent [PDF]
, 2018 Abstract The leading strategy towards eradication of human immunodeficiency virus (HIV) infection is the depletion of viral reservoirs through reversal of viral latency, followed by clearance of persistently infected cells.
Sampey, Gavin C. +12 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Identification of benzazole compounds that induce HIV-1 transcription. [PDF]
PLoS ONE, 2017 Despite advances in antiretroviral therapy, HIV-1 infection remains incurable in patients and continues to present a significant public health burden worldwide.
Jason D Graci +9 more
doaj +1 more source
Molecular Modeling and Synthesis of New HIV Latency-Reversing Agents Targeting the Lymphatic System
Medical Sciences Forum, 2022 During the HIV infection, a small amount of the virus remains in a latent state, forming a viral reservoir in places with limited access to drugs such as lymph nodes. HIV latency reversing agents, as HDAC inhibitors, have been used in the “kick and kill”
Beatriz Meduqui Rodrigues +3 more
doaj +1 more source