Results 41 to 50 of about 844,387 (281)

ECG diagnosis for arrhythmia detection with a cloud-based service and a wearable sensor network in a smart city environment

Frontiers in Sustainable Cities, 2022
Irregular heartbeats are a primary indicator of Cardiovascular Disease (CVD), which is the leading cause of death in a developing smart city environment.
C. Prajitha, K. P. Sridhar, S. Baskar
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Sodium butyrate impedes the lymphoma caused by Marek’s disease virus via regulating the mitochondrial apoptosis pathway

Frontiers in Veterinary Science
Sodium butyrate (NaB) has garnered attention in recent years for its ability to impede the malignant progression of tumors. In order to explore the potential inhibitory effects of NaB on the replication of Marek’s disease virus (MDV) and subsequent ...
Qiaoer Lin, Jun Zhou, Fan Yang, Congsen Zheng, Meiting Chen, Chuanzhe Chang, Shikai Cai, Feng Wen, Feng Wen, Nina Wang, Nina Wang, Yanfeng Chen, Yanfeng Chen, Limei Qin, Limei Qin   +14 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Potrayal of Hyperreality in Movie Latency (2024)

Lingual
This research analyzes the construction of hyperreality in the film Latency (2024) through a descriptive qualitative approach by focusing on Baudrillard's (1981) four stages of simulacra.
Arfian Dwi Saputra, Andri Fernanda
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Dynamic Load Balancing for Enhanced Network Performance in IoT-Enabled Smart Healthcare With Fog Computing

IEEE Access
The rapid expansion of Internet of Things (IoT) devices in healthcare has increased data volumes, creating challenges for the efficiency and latency of real-time monitoring systems.
Mohammed Alaa Ala'anzy, Raiymbek Zhanuzak, Ramis Akhmedov, Nader Mohamed, Jameela Al-Jaroodi   +4 more
doaj   +1 more source

Bioactive molecules released from cells infected with the Human Cytomegalovirus

Frontiers in Microbiology, 2016
Following primary infection in humans, the Human Cytomegalovirus (HCMV) persists in a latent state throughout the host’s lifetime despite a strong and efficient immune response.
Anna eLuganini, Maria Elena eTerlizzi, Giorgio eGribaudo   +2 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants

Cell Reports, 2017
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to determine the distribution of latent replication-competent HIV-1 within ...
Bonnie Hiener, Bethany A. Horsburgh, John-Sebastian Eden, Kirston Barton, Timothy E. Schlub, Eunok Lee, Susanne von Stockenstrom, Lina Odevall, Jeffrey M. Milush, Teri Liegler, Elizabeth Sinclair, Rebecca Hoh, Eli A. Boritz, Daniel Douek, Rémi Fromentin, Nicolas Chomont, Steven G. Deeks, Frederick M. Hecht, Sarah Palmer   +18 more
doaj   +1 more source