Results 141 to 150 of about 26,399 (169)

Development of a latency model based on HIV-1 subtype C to study how long terminal repeat genetic variation impacts viral persistence and latency reversal

Maikoo S, Palstra R, Dong KL, Mahmoudi T, Ndung’u T, Madlala P.   +5 more
europepmc   +1 more source

HIV-1 Latency and Latency Reversal: Does Subtype Matter? [PDF]

Viruses, 2019
Cells that are latently infected with HIV-1 preclude an HIV-1 cure, as antiretroviral therapy does not target this latent population. HIV-1 is highly genetically diverse, with over 10 subtypes and numerous recombinant forms circulating worldwide. In spite of this vast diversity, much of our understanding of latency and latency reversal is largely based
Indra Sarabia, Alberto Bosque, Bosque Alberto   +2 more
exaly   +4 more sources

Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal

ACS Infectious Diseases, 2020
A hallmark of human immunodeficiency type-1 (HIV) infection is the integration of the viral genome into host chromatin, resulting in a latent reservoir that persists despite antiviral therapy or immune response. Thus, key priorities toward eradication of
Anne-Marie W Turner, Raghuvar Dronamraju, Frances Potjewyd   +2 more
exaly   +3 more sources

Novel Latency Reversal Agents for HIV-1 Cure [PDF]

Annual Review of Medicine, 2018
Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART is not curative owing to the persistence of replication-competent, latent proviruses in long-lived resting T cells. Strategies that target these latently infected cells and allow immune recognition and clearance of this reservoir will be necessary to eradicate ...
Adam M Spivak, Vicente Planelles
exaly   +3 more sources

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Reverse Offloading for Latency Minimization in Vehicular Edge Computing

ICC 2021 - IEEE International Conference on Communications, 2021
The safety of autonomous driving can be improved with the support of Cooperative Vehicle-Infrastructure System (CVIS) and Vehicular Edge Computing (VEC), which benefit greatly from crowdsensing of CVIS and accurate decision in a short deadline of VEC.
Weiyang Feng, Shuzhong Yang, Yuan Gao, Ning Zhang 0007, Ruirui Ning, Siyu Lin   +5 more
openaire   +1 more source

Latency-reversing agents: where are we now? [PDF]

Current Opinion in HIV and AIDS
Purpose of review Despite effective antiretroviral therapy (ART), HIV-1 persists in latently infected cells that evade host immunity and can resume viral production upon treatment interruption. To address this challenge, the “shock and kill” strategy aims to use latency-reversing agents (LRAs) to reactivate HIV ...
Bendoumou, Maryam, Van Lint, Carine
openaire   +2 more sources

Reversal of Latency as Part of a Cure for HIV-1

Trends in Microbiology, 2016
Here, the use of pharmacological agents to reverse HIV-1 latency will be explored as a therapeutic strategy towards a cure. However, while clinical trials of latency-reversing agents LRAs) have demonstrated their ability to increase production of latent HIV-1, such interventions have not had an effect on the size of the latent HIV-1 reservoir ...
Rasmussen, Thomas Aagaard; id_orcid 0000-0001-5354-2442, Tolstrup, Martin; id_orcid 0000-0001-7020-5173, Søgaard, Ole Schmeltz   +2 more
openaire   +3 more sources

Latency Reversal and Clearance of Persistent HIV Infection

2022
Efforts to prevent and treat human immunodeficiency virus type 1 (HIV) infection have begun to blunt the spread of HIV infection. Potent, safe, and well-tolerated antiretroviral therapy (ART) allows those infected with HIV to attain a life expectancy similar to that of HIV-uninfected individuals.
openaire   +2 more sources

Class 1-Selective Histone Deacetylase (HDAC) Inhibitors Enhance HIV Latency Reversal while Preserving the Activity of HDAC Isoforms Necessary for Maximal HIV Gene Expression

Journal of Virology, 2018
Combinations of drugs that affect distinct mechanisms of HIV latency aim to induce robust latency reversal leading to cytopathicity and elimination of the persistent HIV reservoir. Thus far, attempts have focused on combinations of protein kinase C (PKC)
Thomas D Zaikos, Mark M Painter, Kathleen L Collins   +2 more
exaly   +2 more sources

The Relevance of Post-Transcriptional Mechanisms in HIV Latency Reversal

Current Pharmaceutical Design, 2017
Infection by the human immunodeficiency virus has become a treatable disease, which could not be cured because the virus persists in the face of an efficacious drug treatment. Current efforts for the rescue of replication-competent virus from cellular reservoirs are limited to drugs targeting transcriptional reactivation of the dormant virus and ...
Sarracino, Ambra, Marcello, Alessandro
openaire   +2 more sources