Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents [PDF]
Journal of Infectious Diseases, 2017 Quiescent proviral genomes that persist during human immunodeficiency virus type 1 (HIV-1) infection despite effective antiretroviral therapy (ART) can fuel rebound viremia after ART interruption and is a central obstacle to the cure of HIV infection.
, Nancie Archin, Archin Nancie M
exaly +5 more sources
Trade-off between synergy and efficacy in combinations of HIV-1 latency-reversing agents. [PDF]
PLoS Computational Biology, 2018 Eradicating HIV-1 infection is difficult because of the reservoir of latently infected cells that gets established soon after infection, remains hidden from antiretroviral drugs and host immune responses, and retains the capacity to reignite infection ...
Vipul Gupta, Narendra M Dixit
doaj +2 more sources
Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy? [PDF]
Viruses, 2021 Rungroch Sungthong +2 more
exaly +2 more sources
Approaches to discover latency-reversing agents
Journal of Virus Eradication, 2015 doaj +2 more sources
Combinations of Histone Deacetylase Inhibitors with Distinct Latency Reversing Agents Variably Affect HIV Reactivation and Susceptibility to NK Cell-Mediated Killing of T Cells That Exit Viral Latency [PDF]
International Journal of Molecular Sciences, 2021 Margherita Doria, Daniela Angela Covino
exaly +2 more sources
Diversity of small molecule HIV‐1 latency reversing agents identified in low‐ and high‐throughput small molecule screens [PDF]
Medicinal Research Reviews, 2020 Ivan Sadowski, Pargol Hashemi
exaly +2 more sources
Identification of a promising new class of latency reversing agents
Journal of Virus Eradication, 2017 A. Gramatica +6 more
doaj +2 more sources
G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells [PDF]
Cell Cycle, 2020 Stephen Dewhurst +2 more
exaly +2 more sources
Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents. [PDF]
AIDS, 2020 Objective: While latently HIV-infected cells have been described in the blood, it is unclear whether a similar inducible reservoir exists in the gut, where most HIV-infected cells reside. Tissue-specific environments may contribute to differences in the mechanisms that govern latent HIV infection and amenability to reactivation.
Telwatte S +8 more
europepmc +6 more sources