Results 31 to 40 of about 6,010 (246)

Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV Cure. [PDF]

Front Immunol, 2018
Antiretroviral therapy regimens durably suppress HIV replication, but do not cure infection. This is partially attributable to the persistence of long-lived pools of resting CD4+ T-cells harboring latent replication-competent virus.
Clutton GT, Jones RB.
europepmc   +4 more sources

Experimental Systems for Measuring HIV Latency and Reactivation

Viruses, 2020
The final obstacle to achieving a cure to HIV/AIDS is the presence of latent HIV reservoirs scattered throughout the body. Although antiretroviral therapy maintains plasma viral loads below the levels of detection, upon cessation of therapy, the latent ...
Koh Fujinaga, Daniele C. Cary
doaj   +1 more source

Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity

Viruses, 2022
Immune cell state alterations rewire HIV-1 gene expression, thereby influencing viral latency and reactivation, but the mechanisms are still unfolding.
Emily Cruz-Lorenzo, Nora-Guadalupe P. Ramirez, Jeon Lee, Sonali Pandhe, Lei Wang, Juan Hernandez-Doria, Adam M. Spivak, Vicente Planelles, Tianna Petersen, Mamta K. Jain, Elisabeth D. Martinez, Iván D’Orso   +11 more
doaj   +1 more source

HIV-1 latency reversal agent boosting is not limited by opioid use

JCI Insight, 2023
Abstract The opioid epidemic may impact the HIV-1 reservoir and its reversal from latency in virally suppressed people with HIV (PWH). We studied forty-seven PWH and observed that lowering the concentration of HIV-1 latency reversal agents (LRA), used in combination with small molecules that do not reverse latency ...
Tyler Lilie, Jennifer Bouzy, Archana Asundi, Jessica Taylor, Samantha Roche, Alex Olson, Kendyll Coxen, Heather Corry, Hannah Jordan, Kiera Clayton, Nina Lin, Athe Tsibris   +11 more
openaire   +3 more sources

Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4+ T cells

eLife, 2018
Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence of latently infected cells. The ‘shock and kill’ approach to a cure proposes to eliminate this reservoir via transcriptional activation of latent proviruses ...
Emilie Battivelli, Matthew S Dahabieh, Mohamed Abdel-Mohsen, J Peter Svensson, Israel Tojal Da Silva, Lillian B Cohn, Andrea Gramatica, Steven Deeks, Warner C Greene, Satish K Pillai, Eric Verdin   +10 more
doaj   +1 more source

TLR7 Agonist GS–9620 Combined with Nicotinamide Generate Viral Reactivation in Seronegative SHIV_SF162P3-Infected Rhesus Monkeys

Biomedicines, 2023
Antiretroviral therapy is capable of inhibiting HIV replication, but it fails to completely achieve a cure due to HIV persistence. The commonly used HIV cure approach is the “shock and kill” strategy, which employs latency-reversing agents to trigger ...
Zhe Cong, Yuting Sun, Cui Dang, Chenbo Yang, Jingjing Zhang, Jiahan Lu, Ting Chen, Qiang Wei, Wei Wang, Jing Xue   +9 more
doaj   +1 more source

Relationship between Measures of HIV Reactivation and Decline of the Latent Reservoir under Latency-Reversing Agents. [PDF]

J Virol, 2017
Antiretroviral-free HIV remission requires substantial reduction of the number of latently infected cells and enhanced immune control of viremia.
Petravic J, Rasmussen TA, Lewin SR, Kent SJ, Davenport MP.   +4 more
europepmc   +2 more sources

Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch. [PDF]

Retrovirology, 2015
Background\ud Latent HIV-1 reservoirs are identified as one of the major challenges to achieve HIV-1 cure. Currently available strategies are associated with wide variability in outcomes both in patients and CD4+ T cell models.
Venkatachari NJ, Zerbato JM, Jain S, Mancini AE, Chattopadhyay A, Sluis-Cremer N, Bar-Joseph Z, Ayyavoo V.   +7 more
europepmc   +2 more sources

Coloring hidden viruses

eLife, 2018
An improved dual-color reporter reveals how the fate of latent HIV-1 depends on where it integrates in the human genome.
Marina Lusic
doaj   +1 more source

Histone deacetylase inhibitors containing a benzamide functional group and a pyridyl cap are preferentially effective human immunodeficiency virus-1 latency-reversing agents in primary resting CD4+ T cells [PDF]

Journal of General Virology, 2017
Celine Gelinas, Joseph P Dougherty
exaly   +2 more sources