Results 51 to 60 of about 6,010 (246)

Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling

, 2017
International audienceIn this study, we looked for a new family of latency reversing ...
Campos, Noëlie, Pierre Corbeau, Maurel, Damien, Sandrine Gimenez, Comps-Agrar, Laetitia, Prézeau, Laurent, Etienne Doumazane, Laetitia Comps-Agrar, Gimenez, Sandrine, Clément Mettling, Benjamin Viala, Caroline Boulouis, Laurent Prézeau, Duquenne, Charline, Charline Duquenne, Jamal Tazi, Boulouis, Caroline, Psomas, Christina, François, Vincent, Noëlie Campos, Doumazane, Etienne, Damien Maurel, Viala, Benjamin, Guigues, Adeline, Tazi, Jamal, Corbeau, Pierre, Vincent François, Christina Psomas, Adeline Guigues, Mettling, Clément   +29 more
core   +1 more source

Discovering the Mechanisms of Oleodaphnone as a Potential HIV Latency-Reversing Agent by Transcriptome Profiling

International Journal of Molecular Sciences, 2023
Latent HIV is a key factor that makes AIDS difficult to cure. Highly effective and specific latent HIV activators can effectively activate latent HIV, and then combined with antiretroviral therapy to achieve a functional cure of AIDS. Here, four sesquiterpenes (1–4) including a new one (1), five flavonoids (5–9) including three biflavonoid structures ...
Shifei Li, Xiuyi Wang, Yuqin Yang, Xingkang Wu, Liwei Zhang   +4 more
openaire   +2 more sources

Characterization of Inducible Transcription and Translation-Competent HIV-1 Using the RNAscope ISH Technology at a Single-Cell Resolution

Frontiers in Microbiology, 2018
Identifying the source and dynamics of persistent HIV-1 at single-cell resolution during cART is crucial for the design of strategies to eliminate the latent HIV-1 reservoir.
Wang Zhang, Wang Zhang, Sara Svensson Akusjärvi, Anders Sönnerborg, Anders Sönnerborg, Ujjwal Neogi   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Identification of benzazole compounds that induce HIV-1 transcription. [PDF]

PLoS ONE, 2017
Despite advances in antiretroviral therapy, HIV-1 infection remains incurable in patients and continues to present a significant public health burden worldwide.
Jason D Graci, Daniel Michaels, Guangming Chen, Gillian M Schiralli Lester, Sarah Nodder, Marla Weetall, Gary M Karp, Zhengxian Gu, Joseph M Colacino, Andrew J Henderson   +9 more
doaj   +1 more source

Molecular Modeling and Synthesis of New HIV Latency-Reversing Agents Targeting the Lymphatic System

Medical Sciences Forum, 2022
During the HIV infection, a small amount of the virus remains in a latent state, forming a viral reservoir in places with limited access to drugs such as lymph nodes. HIV latency reversing agents, as HDAC inhibitors, have been used in the “kick and kill”
Beatriz Meduqui Rodrigues, Juliana Romano Lopes, Andressa Francielli Bonjorno, Jean Leandro dos Santos   +3 more
doaj   +1 more source

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. [PDF]

PLoS Pathog, 2016
Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently ...
Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD.   +25 more
europepmc   +2 more sources

Optimal control of an HIV model with gene therapy and latency reversing agents

, 2022
In this project, we study the dynamics of HIV under gene therapy and latency reversing agents. For constant treatment controls, we establish global stability of the disease-free equilibrium and endemic equilibrium based on the value of the basic ...
Hazelton, Paul, Grant, Andrew, Grant, Andrew B   +2 more
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source