Results 71 to 80 of about 5,637 (225)
Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency
EMBO Molecular Medicine, 2017 Highly active antiretroviral therapy (HAART) has improved the outlook for the HIV epidemic, but does not provide a cure. The proposed “shock‐and‐kill” strategy is directed at inducing latent HIV reservoirs, which may then be purged via boosted immune ...
Pargol Hashemi +7 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.The article overviews past and current efforts on caloric materials and systems, highlighting the contributions of Ames National Laboratory to the field. Solid‐state caloric heat pumping is an innovative method that can be implemented in a wide range of cooling and heating applications.
Agata Czernuszewicz +5 more
wiley +1 more source
Advanced Robotics Research, EarlyView.Automated poultry processing lines still rely on humans to lift slippery, easily bruised carcasses onto a shackle conveyor. Deformability, anatomical variance, and hygiene rules make conventional suction and scripted motions unreliable. We present ChicGrasp, an end‐to‐end hardware‐software co‐designed imitation learning framework, to offer a ...
Amirreza Davar +8 more
wiley +1 more source
Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab
Nature Communications, 2019 Here, the authors identify B lymphocyte antigen CD20 as a marker for HIV-infected T cells and provide evidence for the potential use of anti-CD20 antibodies in combination with latency reversing agents for depletion of viral reactivated CD4 T cells in ...
Carla Serra-Peinado +19 more
doaj +1 more source
Compliant Pneumatic Feet with Real‐Time Stiffness Adaptation for Humanoid Locomotion
Advanced Robotics Research, EarlyView.A compliant pneumatic foot with real‐time variable stiffness enables humanoid robots to adapt to changing terrains. Using onboard vision and pressure control, the foot modulates stiffness within each gait cycle, reducing impact forces and improving balance. The design, cast in soft silicone with embedded air chambers and Kevlar wrapping, offers durable,
Irene Frizza +3 more
wiley +1 more source
The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2
JCI InsightNonreceptor tyrosine phosphatases (NTPs) play an important role in regulating protein phosphorylation and have been proposed as attractive therapeutic targets for cancer and metabolic diseases. We have previously identified that 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one (HODHBt) enhanced STAT activation upon cytokine stimulation, leading to increased ...
J. Natalie Howard +12 more
openaire +2 more sources
Broad activation of latent HIV-1 in vivo
Nature Communications, 2016 Treatment of HIV-1 infected patients with latency-reversing agents (LRA) induces transcription of proviruses in CD4 T cells. Using single-genome sequencing, the authors show that the LRA-induced CD4 T cell-associated HIV RNA is genetically diverse and ...
Kirston Barton +18 more
doaj +1 more source
Miniaturized Magnetic Tip Design for Endoluminal Vine Robot Navigation
Advanced Robotics Research, EarlyView.A magnetic tip mount is designed for a miniaturized 7 mm soft‐growing vine robot to enable wireless magnetic steering and onboard imaging, while preserving a 3 mm working channel. The internal–external ring magnets design balances magnetic attachment with low eversion pressure. Experiments demonstrate ±90° steering, 34 mm bending radius, and successful
Andrea Yanez Trujillo +4 more
wiley +1 more source
Advanced Robotics Research, EarlyView.A flexible, skin‐integrated electromagnetic actuator is developed for wearable virtual/augmented reality (VR/AR) haptic systems. A tunable design model enables control over displacement and resonance frequency. The system is validated through a custom VR application with a 6 × 4 actuator array, demonstrating real‐time, spatially targeted tactile ...
Naji Tarabay +9 more
wiley +1 more source
TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb
eLife, 2019 Comprehensively elucidating the molecular mechanisms of human immunodeficiency virus type 1 (HIV-1) latency is a priority to achieve a functional cure.
Xiancai Ma +22 more
doaj +1 more source