Results 71 to 80 of about 1,759,507 (251)
Advanced Functional Materials, EarlyView.The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan +4 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou +6 more
wiley +1 more source
Development of novel HIV-1 latency reversing agents [PDF]
, 2018 © 2018 Dr. Jonathan Colin JacobsonHIV-1 establishes a highly stable latent reservoir early in infection, necessitating lifelong combinational antiretroviral therapy. Elimination of the latent reservoir remains a significant roadblock for a functional HIV-
Jacobson, Jonathan
core +1 more source
Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure
Viruses, 2023 Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control of ...
Natasha N. Duggan +3 more
doaj +1 more source
Photo‐Switchable Molecular Module Programming PET Biodegradation in Aquatic Environments
Advanced Functional Materials, EarlyView.We address the plastic durability paradox by integrating an itaconic acid–derived pyrrolidone module into polymer backbones. Sunlight in water triggers Norrish Type I ring‐opening and hydrophilization, enabling rapid biodegradation into nontoxic minerals.
Mohammad Asif Ali +16 more
wiley +1 more source
Shocking HIV out of hiding: Where are we with clinical trials of latency reversing agents?
, 2016 PURPOSE OF REVIEW: To provide an overview of the initial experiences with the use of latency-reversing agents (LRAs) in clinical trials in HIV and to discuss and contrast results arising from these studies.
Rasmussen, TA, Lewin, SR
core +1 more source
Adaptive Latency Insensitive Protocols [PDF]
, 2007 Latency-insensitive design copes with excessive delays typical of global wires in current and future IC technologies. It achieves its goal via encapsulation of synchronous logic blocks in wrappers that communicate through a latency-insensitive protocol ...
Casu, Mario Roberto, Macchiarulo, Luca
core +1 more source
Advanced Functional Materials, EarlyView.Nitride MXenes remain constrained by a persistent gap between computational prediction and experimental realization. This Review identifies the thermodynamic, kinetic, and chemical barriers limiting their synthesis, critically evaluates emerging fabrication routes, and proposes a multidimensional computational‐experimental framework to accelerate the ...
Naresh Varnakavi, Masoud Soroush
wiley +1 more source
Global Dynamics of the HIV Latent Reservoir with Latency Reversing Agents and Immune Response
, 2020 In this project, we model the dynamics of HIV-1 latently infected cells under the effects of latency reversing agents (LRAs) to promote a natural immune response. We establish the existence of immune-free and positive equilibria and then utilize Lyapunov
Berchtold, Claire, Mitchum, Hannah
core +1 more source
HeliyonCurrently, highly active antiretroviral therapy is unable to cure HIV/AIDS because of HIV latency. This study aimed at documenting medicinal plants used in the management of HIV/AIDS in Eastern Uganda so as to identify phytochemicals with HIV latency ...
Richard Oriko Owor +15 more
doaj +1 more source