Results 81 to 90 of about 6,010 (246)

Ethnobotanical survey and phytochemistry of medicinal plants used in the management of HIV/AIDS in Eastern Uganda

Heliyon
Currently, highly active antiretroviral therapy is unable to cure HIV/AIDS because of HIV latency. This study aimed at documenting medicinal plants used in the management of HIV/AIDS in Eastern Uganda so as to identify phytochemicals with HIV latency ...
Richard Oriko Owor, Carol Kawuma, Gauden Nantale, Kenedy Kiyimba, Samuel Baker Obakiro, Simple Ouma, Jalia Lulenzi, Yahaya Gavamukulya, Mercy Chebijira, Tonny Wotoyitide Lukwago, Moses Egor, Peter Musagala, Moses Andima, Dan Kibuule, Paul Waako, Joseph Hokello   +15 more
doaj   +1 more source

Total Syntheses of Phorbol and 11 Tigliane Diterpenoids and Their Evaluation as HIV Latency-Reversing Agents

Tigliane diterpenoids possess exceptionally complex structures comprising common 5/7/6/3-membered ABCD-rings and disparate oxygen functionalities.
Masanori Nagatomo (1696051), Satoshi Miura (2667748), Yuto Hikone (11972034), Masayuki Inoue (737292), Akira Hirose (480633), Naoki Kishimoto (82096), Tae Yasutake (18159149), Ayumu Watanabe (11198938), Towa Abe (9369889), Shogo Misumi (2289145)   +9 more
core   +1 more source

From the Discovery of the Giant Magnetocaloric Effect to the Development of High‐Power‐Density Systems

Advanced Materials Technologies, EarlyView.
The article overviews past and current efforts on caloric materials and systems, highlighting the contributions of Ames National Laboratory to the field. Solid‐state caloric heat pumping is an innovative method that can be implemented in a wide range of cooling and heating applications.
Agata Czernuszewicz, Yaroslav Mudryk, Jun Cui, Lucas Griffith, Duane D. Johnson, Julie Slaughter   +5 more
wiley   +1 more source

PolyIC-coated Prussian blue nanoparticles as a dual-mode HIV latency reversing agent - Supplementary dataset

, 2023
Aim: To investigate Prussian blue nanoparticles (PBNPs) coated with the synthetic analog of dsRNA polyinosinic-polycytidylic acid (polyIC) for their ability to function as HIV latency reversing agents.
Preethi B Balakrishnan (14563084), Carissa S Holmberg (14563086), Debbie K Ledezma (14563087), Alberto Bosque (202328), Rohan Fernandes (1438021)   +4 more
core   +1 more source

Transducers Across Scales and Frequencies: A System‐Level Framework for Multiphysics Integration and Co‐Design

Advanced Materials Technologies, EarlyView.
Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu, Mengyao Xiao, Zhouli Sui, Yinpeng Wang, Daoye Zheng, Yuxin Liu, Luwei Wang, Huajun Liu, Chengkuo Lee   +8 more
wiley   +1 more source

Development of novel HIV-1 latency reversing agents [PDF]

, 2018
© 2018 Dr. Jonathan Colin JacobsonHIV-1 establishes a highly stable latent reservoir early in infection, necessitating lifelong combinational antiretroviral therapy. Elimination of the latent reservoir remains a significant roadblock for a functional HIV-
Jacobson, Jonathan
core  

ChicGrasp: Imitation‐Learning‐Based Customized Dual‐Jaw Gripper Control for Manipulation of Delicate, Irregular Bio‐Products

Advanced Robotics Research, EarlyView.
Automated poultry processing lines still rely on humans to lift slippery, easily bruised carcasses onto a shackle conveyor. Deformability, anatomical variance, and hygiene rules make conventional suction and scripted motions unreliable. We present ChicGrasp, an end‐to‐end hardware‐software co‐designed imitation learning framework, to offer a ...
Amirreza Davar, Zhengtong Xu, Siavash Mahmoudi, Pouya Sohrabipour, Chaitanya Pallerla, Yu She, Wan Shou, Philip Glen Crandall, Dongyi Wang   +8 more
wiley   +1 more source

The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2

JCI Insight
Nonreceptor tyrosine phosphatases (NTPs) play an important role in regulating protein phosphorylation and have been proposed as attractive therapeutic targets for cancer and metabolic diseases. We have previously identified that 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one (HODHBt) enhanced STAT activation upon cytokine stimulation, leading to increased ...
J. Natalie Howard, Thomas D. Zaikos, Callie Levinger, Esteban Rivera, Elyse K. McMahon, Carissa S. Holmberg, Joshua Terao, Marta Sanz, Dennis C. Copertino, Weisheng Wang, Natalia Soriano-Sarabia, R. Brad Jones, Alberto Bosque   +12 more
openaire   +2 more sources

A macrophage-cell model of HIV latency reveals the unusual importance of the bromodomain axis

Virology Journal
Background Although macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and reactivated in these cell types is poorly understood.
Javan K. Kisaka, Daniel Rauch, Malachi Griffith, George B. Kyei   +3 more
doaj   +1 more source

Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency

EMBO Molecular Medicine, 2017
Highly active antiretroviral therapy (HAART) has improved the outlook for the HIV epidemic, but does not provide a cure. The proposed “shock‐and‐kill” strategy is directed at inducing latent HIV reservoirs, which may then be purged via boosted immune ...
Pargol Hashemi, Kris Barreto, Wendy Bernhard, Adam Lomness, Nicolette Honson, Tom A Pfeifer, P Richard Harrigan, Ivan Sadowski   +7 more
doaj   +1 more source