Results 61 to 70 of about 1,759,507 (251)
Identification of benzazole compounds that induce HIV-1 transcription. [PDF]
PLoS ONE, 2017 Despite advances in antiretroviral therapy, HIV-1 infection remains incurable in patients and continues to present a significant public health burden worldwide.
Jason D Graci +9 more
doaj +1 more source
New AI‐Assisted Approach for Expanding the Solution Space: Application to Lattice Structure Design
Advanced Engineering Materials, EarlyView.This work introduces an innovative framework for designing structured materials by ex panding the design space through reparameterization of qualitative variables into continuous structural descriptors. Combined with machine‐learning‐based prediction and multi‐objective optimization, the approach enables the discovery of novel lattice architectures ...
G. H. Gahimbare +5 more
wiley +1 more source
Optimal control of an HIV model with gene therapy and latency reversing agents
, 2023 In this project, we study the dynamics of HIV under gene therapy and latency reversing agents. For constant treatment controls, we establish global stability of the disease-free equilibrium and endemic equilibrium based on the value of the basic ...
Hazelton, Paul, Grant, Andrew
core
Issues in Implementing Latency Insensitive Protocols [PDF]
, 2004 The latency insensitive protocols (LIP), which are designed to improve the performance of systems-on-chip, were refined. The refined protocol was validated by using many proof-of-concept examples, that comprised of various combinations of feedforward and
L. Macchiarulo +3 more
core +1 more source
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo [PDF]
, 2021 An ability to activate latent HIV-1 expression could benefit many HIV cure strategies, but the first generation of latency reversing agents (LRAs) has proven disappointing. We evaluated AKT/mTOR activators as a potential new class of LRAs.
Roan, Nadia R +31 more
core +1 more source
Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?
VirusesHuman Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara +1 more
doaj +1 more source
Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials
Advanced Engineering Materials, EarlyView.Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley +1 more source
Novel Triazolopyridine-Based BRD4 Inhibitors as Potent HIV‑1 Latency Reversing Agents
, 2023 Bromodomain-containing protein 4 (BRD4) inhibitors have been proven to be a promising option for anti-HIV-1 latency therapeutics. We herein describe the design, synthesis, and anti-HIV-1 latency bioevaluation of triazolopyridine derivatives as BRD4 ...
Zhi-Yu Li (7008698) +13 more
core +1 more source
The SMAC Mimetic AZD5582 is a Potent HIV Latency Reversing Agent [PDF]
, 2018 Abstract The leading strategy towards eradication of human immunodeficiency virus (HIV) infection is the depletion of viral reservoirs through reversal of viral latency, followed by clearance of persistently infected cells.
Sampey, Gavin C. +12 more
openaire +1 more source
Advanced Engineering Materials, EarlyView.Gallium microalloying redirects interfacial reactions in low‐temperature Bi–Sn solders from Cu–Sn toward Cu–Ga intermetallic formation. The resulting Cu–Ga layer suppresses intermetallic growth during thermal aging, alters fracture pathways, and improves interfacial stability.
Iva Králová +6 more
wiley +1 more source