Results 211 to 220 of about 5,637 (225)

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Journal of Visualized Experiments, 2019
HIV remains incurable due to the existence of a reservoir of cells that harbors stable and latent form of the virus, which stays invisible to the immune system and is not targeted by the current antiretroviral therapy (cART). Transcription and splicing have been shown to reinforce HIV-1 latency in resting CD4+ T cells. Reversal of latency by the use of
Georges, Khoury, Damian F J, Purcell
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Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents

ACS Infectious Diseases
Toward human immunodeficiency virus type-1 (HIV-1) cure, cells latently infected with HIV-1 must be eliminated from people living with HIV-1. We previously developed a protein kinase C (PKC) activator, diacylglycerol (DAG)-lactone derivative 3, with high HIV-1 latency-reversing activity, based on YSE028 (2) as a lead compound and found that the ...
Takahiro Ishii, Takuya Kobayakawa, Kouki Matsuda, Kiyomi Nigorikawa, Peter Bolah, Airi Noborio, Kohei Tsuji, Nami Ohashi, Kazuhisa Yoshimura, Wataru Nomura, Hiroaki Mitsuya, Kenji Maeda, Hirokazu Tamamura   +12 more
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THE CURRENT STATUS OF LATENCY REVERSING AGENTS

2019
info:eu-repo/semantics ...
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Creation of an Improved HIV Latency Model to Test Latency Reversal Agents

HIV is a retrovirus that infects CD4+ T-cells by integrating into the human genome. During productive infection, the virus enters a latent state in a small subset of cells. This allows HIV to persist and remain undetected by the immune system and current antiretroviral therapies (ART). While ART is highly effective at controlling HIV, it is not a
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Human Immunodeficiency Virus and Latency Reversing Agents A Path to Cure?

2017
Background: Human immunodeficiency virus (HIV), as its namesake implies, is a virus that ultimately causes a deficient immune system that can lead to Acquired Immune Deficiency Syndrome (AIDS). Since the discovery of this cytopathic virus in 1983, there have been many scientific advances in regards to its identification and treatment.
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Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency‐Reversing Agents

Chemistry - A European Journal, 2023
Kenichi Murai, Mitsuhiro Arisawa
exaly  

Potential HIV latency-reversing agents with STAT1-activating activity from the leaves of Wikstroemia chamaedaphne

Phytochemistry, 2022
Shifei Li
exaly  

HIV‐1 infection and latency‐reversing agents bryostatin‐1 and JQ1 disrupt amyloid beta homeostasis in human astrocytes

Glia, 2020
Michel J Tremblay, Alize Proust
exaly  

Ex vivo model of HIV latency to screen latency-reversing agents

Science-Business eXchange, 2014
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New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

Nature Medicine, 2014
Janet Siliciano, Robert Siliciano, Christine M Durand   +2 more
exaly