Results 231 to 240 of about 6,010 (246)
Shocking HIV-1 with immunomodulatory latency reversing agents [PDF]
Seminars in Immunology, 2021 The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to ...
Anna Kula-Pacurar +2 more
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The Current Status of Latency Reversing Agents for HIV-1 Remission [PDF]
Annual Review of Virology, 2021 Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected ...
Anthony Rodari, Gilles Darcis
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T cell toxicity of HIV latency reversing agents
Pharmacological Research, 2019 Combination antiretroviral therapy reduces morbidity and mortality in HIV infected patients. However, the cure of HIV infection is hindered by the persistence of the latent HIV reservoir. Latency reversing agents (LRAs) are developed to target the HIV latently infected cells for HIV reactivation.
Manzhi Zhao +2 more
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Latency-reversing agents: where are we now? [PDF]
Current Opinion in HIV and AIDSPurpose of review Despite effective antiretroviral therapy (ART), HIV-1 persists in latently infected cells that evade host immunity and can resume viral production upon treatment interruption. To address this challenge, the “shock and kill” strategy aims to use latency-reversing agents (LRAs) to reactivate HIV ...
Bendoumou, Maryam, Van Lint, Carine
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HIV latency reversal agents: A potential path for functional cure?
European Journal of Medicinal Chemistry, 2021Despite the advances in Human Immunodeficiency Virus (HIV) treatment, the cure for all HIV patients still poses a major challenge, which needs to be surpassed in the coming years. Among the strategies pursuing this aim, the 'kick-and-kill' approach, which involves the reactivation and elimination of a latent HIV reservoir that resides in some CD4+ T ...
Juliana Romano Lopes +2 more
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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
Journal of Visualized Experiments, 2019HIV remains incurable due to the existence of a reservoir of cells that harbors stable and latent form of the virus, which stays invisible to the immune system and is not targeted by the current antiretroviral therapy (cART). Transcription and splicing have been shown to reinforce HIV-1 latency in resting CD4+ T cells. Reversal of latency by the use of
Georges, Khoury, Damian F J, Purcell
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Advances in structure-activity relationships of HDAC inhibitors as HIV latency-reversing agents
Expert Opinion on Drug DiscoveryHIV-infected cells may rebound due to the existence of the silent HIV-infected memory CD4+ T cells (HIV latency). This HIV latency makes the disease almost incurable. In latency, the integrated proviral DNA of HIV is transcriptionally silenced partly due to the activity of histone deacetylases (HDACs).
Samima Khatun +2 more
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Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents
ACS Infectious DiseasesToward human immunodeficiency virus type-1 (HIV-1) cure, cells latently infected with HIV-1 must be eliminated from people living with HIV-1. We previously developed a protein kinase C (PKC) activator, diacylglycerol (DAG)-lactone derivative 3, with high HIV-1 latency-reversing activity, based on YSE028 (2) as a lead compound and found that the ...
Takahiro Ishii +12 more
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THE CURRENT STATUS OF LATENCY REVERSING AGENTS
2019info:eu-repo/semantics ...
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Human Immunodeficiency Virus and Latency Reversing Agents A Path to Cure?
2017Background: Human immunodeficiency virus (HIV), as its namesake implies, is a virus that ultimately causes a deficient immune system that can lead to Acquired Immune Deficiency Syndrome (AIDS). Since the discovery of this cytopathic virus in 1983, there have been many scientific advances in regards to its identification and treatment.
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