Results 31 to 40 of about 119,179,614 (214)

First Genome Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes [PDF]

, 2018
Objective: Latent autoimmune diabetes in adults (LADA) shares clinical features with both type 1 and type 2 diabetes; however there is ongoing debate regarding the precise definition of LADA.
Hodge, Kenyaita, Asvold, Bjorn Olav, Khunti, Kamlesh, Pratley, RE, Fritsche, LG, Andersen, Mette K., Cousminer, Diana, Boehm, Bernhard Otto, Cousminer, Diana L., Bradfield, JP, Pedersen, Oluf, Vella, Adrian, Leslie, RD, Pearson, Ewan; id_orcid, Pearson, Ewan, Mauricio, Didac, Mishra, R, Pratley, Richard, Guy, Vanessa C., Kim, Cecilia, Groop, L, Chesi, Alessandra, Beck-Nielsen, H, Hodge, KM, Hawa, Mohammad I., Hawa, Mohammad, Kalkwarf, Heidi, Højlund, Kurt, Rickels, Michael R., Boehm, Bernhard O., Harris, Ronald, Greenbaum, Carla, Käräjämäki, Annemari, Hawa, MI, Yderstraede, Knud B., Åsvold, BO, Grarup, Niels, Hansen, T, Zhou, Kaixin, Lonsdale, JT, Grarup, N, Hodge, Kenyaita M., Schwartz, S, Varvel, Stephen, Hakonarson, Hakon, Linneberg, Allan, Voight, Benjamin F, Lonsdale, John, Grant, SFA, Shepherd, John, Pratley, Richard E., Yderstræde, KB, David Leslie, R, Yderstræde, Knud B., Schwartz, Stanley, Greenbaum, CJ, Davis, A, Pearson, ER, Andersen, MK, Boehm, BO, Andersen, Mette, Mishra, Rajashree, Wod, Mette, Vestergaard, H, Bone Mineral Density Childhood, Andersen , Mette K., Voight, BF, Sorgjerd, Elin Pettersen, Voight, Benjamin F., Voight, Benjamin, Melander, O, Groop, Leif C., Leslie, R. David, Pearson, Ewan R., Bradfield, Jonathan, Lonsdale, John T., Schloot, Nanette, Hakonarson, Hakon H., Brandslund, I, Grill, VER, Lappe, Joan, Beck-Nielsen, Henning, Ovalle, Fernando, Snyder, James, Kim, Cecilia E., Ovalle, F, Gilsanz, Vicente, Zhou, K, Rickels, MR, Grant, Struan F A, Käräjämäki, A, Varvel, S, Mauricio, D, Mccormack, Shana, Melander, Olle, Hakonarson, H, Tuomi, T, Fritsche, Lars G., Schloot, Nanette C., Zemel, Babette, Snyder, J, Harris, Ronald I., Khunti, K, Rickels, Michael, ?, ?, Kim, CE, Hansen, Torben, Bradfield, Jonathan P., Gran, Struan F.A., Davis, Asa, Brillon, DJ, Witte, Daniel, Froguel, Philippe, Vella, A, Bone Mineral Density in Childhood Study, Greenbaum, Carla J., Schloot, NC, Guy, Vanessa, Kelly, Andrea, Mitchell, Jonathan, Højlund, K, Witte, D, Witte, Daniel R., Boehm, Bernhard, Oberfield, Sharon, Brillon, David J., Grant, Struan F.A., Wod, M, Pedersen, O, Fritsche, Lars, Sørgjerd, Elin Pettersen, Sørgjerd, EP, Harris, RI, Cousminer, Diana L, Asvold, Bjørn Olav, Åkerlund, M, Yderstræde, Knud, Chesi, A, Leslie, R David, Cousminer, DL, Linneberg, A, Groop, Leif, Brillon, David, Grant, Struan F. A., Brandslund, Ivan, Ahlqvist, E, Vestergaard, Henrik, Guy, VC, Grill, Valdemar E. R., Åkerlund, Mikael, Grill, Valdemar E.R., Ahlqvist, Emma, Froguel, P, Tuomi, Tiinamaija, Ahlqvist, Emma,, Cousminer, Diana L,, Tuomi, Tiinamaija,, Melander, Olle,, Lund University., Grant, Struan F A,, Groop, Leif C, Voight, Benjamin F,, Groop, Leif,, Åkerlund, Mikael,, Leslie, R. David,   +164 more
core   +1 more source

Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel [PDF]

, 2020
A substantial proportion of patients with adult-onset diabetes share features of both type 1 diabetes (T1D) and type 2 diabetes (T2D). These individuals, at diagnosis, clinically resemble T2D patients by not requiring insulin treatment, yet they have ...
Tuomi, T, Buzzetti, Raffaella, Pozzilli, P, Zhou, Z, Buzzetti, R, Pietropaolo, M, Leslie, Richard David, Leslie, RD, Pietropaolo, Massimo, Pozzilli, Paolo, Mauricio, Didac, Zhou, Zhiguang, Mauricio, D, Tuomi, Tiinamaija, Leslie, Richard David,, Tuomi T., Pozzilli P., Buzzetti R., Pietropaolo M., Tuomi, Tiinamaija,, Mauricio D., Mauricio, Didac,, Zhou, Zhiguang,, Leslie R. D., Pozzilli, Paolo,, Zhou Z., Pietropaolo, Massimo,, Buzzetti, Raffaella,, Lund University.   +28 more
core   +1 more source

Latent autoimmune diabetes in adults

The Biomedical & Life Sciences Collection, 2013
Latent Autoimmune Diabetes in Adults (LADA) is the term used to describe adults who have a slowly progressive form of diabetes mellitus (DM) of autoimmune etiology, but that may be treated initially without insulin. Although it shares some immunological and genetic aspects with type 1 DM, it affects an age group that is typically affected by type 2 DM.
Felipe, Pollak, Tatiana, Vásquez
openaire   +3 more sources

The role of cholecalciferol deficiency in the development of latent autoimmune diabetes in adults

Mìžnarodnij Endokrinologìčnij Žurnal, 2023
Background. Recently, a lot of information has appeared on the role of cholecalciferol deficiency in the development of the mechanisms of classical types of diabetes mellitus (DM) and its complications.
I.O. Tsaryk, N.V. Pashkovska
doaj   +1 more source

Latent autoimmune diabetes in youth: a new challenge for the clinician (literature review and own data)

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Latent autoimmune diabetes in youth (LADY) is underdiagnosed form of autoimmune diabetes that combines features of type 1 (T1DM) and type 2 diabetes mellitus (T2DM). In contrast to classical T1DM, LADY is characterized by a slowly progressive
N. Pashkovska, I. Tsaryk
doaj   +1 more source

Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

BMC Medicine, 2017
Background In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as ‘latent autoimmune diabetes in adults’ (LADA). In this study, we investigated established type 1 diabetes (T1D) and type 2 diabetes (T2D) genetic loci ...
Rajashree Mishra, Alessandra Chesi, Diana L. Cousminer, Mohammad I. Hawa, Jonathan P. Bradfield, Kenyaita M. Hodge, Vanessa C. Guy, Hakon Hakonarson, Bone Mineral Density in Childhood Study, Didac Mauricio, Nanette C. Schloot, Knud B. Yderstræde, Benjamin F. Voight, Stanley Schwartz, Bernhard O. Boehm, Richard David Leslie, Struan F. A. Grant   +16 more
doaj   +1 more source

Hybrid diabetes in a patient with latent autoimmune diabetes in adults and genetic markers of predisposition to type 2 diabetes and obesity. Сlinical observation

Лечащий Врач, 2023
We present a case report of a 40-year-old Caucasian man who was diagnosed with type 2 diabetes mellitus at the age of 27. In his case, the patient took oral hypoglycemic drugs for 6 months, but then insulin therapy was started because glycemic goals were
A. V. Vetrova, M. M. Orlova, N. E. Kolobanova   +2 more
doaj   +1 more source

Interventions for latent autoimmune diabetes (LADA) in adults [PDF]

Cochrane Database of Systematic Reviews, 2007
Latent autoimmune diabetes in adults (LADA) is a slowly developing type 1 diabetes.To compare interventions used for LADA.Studies were obtained from searches of electronic databases, supplemented by handsearches, conference proceedings and consultation with experts. Date of last search was December 2010.Randomised controlled trials (RCT) and controlled
S, Brophy, H, Brunt, H, Davies, S, Mannan, R, Williams   +4 more
openaire   +8 more sources

Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes

BMC Endocrine Disorders, 2020
Background A growing body of evidence supports neutrophils as having an active role in the development of diabetic kidney disease (DKD). However, the clinical relevance of neutrophils and DKD in autoimmune diabetes remains unknown.
Yao Yu, Qiuqiu Lin, Dewei Ye, Yanfei Wang, Binbin He, Yanhua Li, Gan Huang, Zhiguang Zhou, Yang Xiao   +8 more
doaj   +1 more source

Glutamic Acid Decarboxylase Autoantibody Detection by Electrochemiluminescence Assay Identifies Latent Autoimmune Diabetes in Adults with Poor Islet Function [PDF]

Diabetes & Metabolism Journal, 2020
BackgroundThe detection of glutamic acid decarboxylase 65 (GAD65) autoantibodies is essential for the prediction and diagnosis of latent autoimmune diabetes in adults (LADA).
Yuxiao Zhu, Li Qian, Qing Liu, Jing Zou, Ying Zhou, Tao Yang, Gan Huang, Zhiguang Zhou, Yu Liu   +8 more
doaj   +1 more source