Results 41 to 50 of about 119,179,614 (214)

Small fibre neuropathy in patients with latent autoimmune diabetes in adults

, 2015
The prevalence of latent autoimmune diabetes in adults (LADA) in patients diagnosed with type 2 diabetes mellitus (T2DM) ranges from 7 to 10% (1). They present at a younger age and have a lower BMI but poorer glycemic control, which may increase the risk
Asghar, Omar, Fadavi, Hassan, Tavakoli, M, Ponirakis, Georgios, Ponirakis, Georgos, Malik, Rayaz A, Petropoulos, Ioannis, Petropoulos, Ioannis N., Efron, Nathan, Boulton, Andrew J.M., Jeziorska, Maria, Efron, N, Malik, Rayaz A., Boulton, AJM, Alam, Uazman, Asghar, O, Petropoulos, Ioannis N, Tavakoli, Mitra, Marshall, Andrew, Boulton, Andrew J M   +19 more
core   +1 more source

IMMUNOLOGICAL MARKERS OF DIABETES MELLITUS IN VARIOUS CLINICAL VARIANTS OF THE DISORDER

Медицинская иммунология, 2014
. We studied immune markers of diabetes mellitus, as well as their relations to clinical features at the onset of disease. The patients with newly diagnosed diabetes were examined.
G. G. Baiburina
doaj   +1 more source

Latent Autoimmune Diabetes in Adults: Current Status and New Horizons [PDF]

Endocrinology and Metabolism, 2018
Autoimmune diabetes is a heterogeneous disease which can arise at any age. Subjects with adult-onset autoimmune diabetes who do not necessitate insulin-therapy for at least 6 months after diagnosis are demarcated as having latent autoimmune diabetes in ...
Paolo Pozzilli, Silvia Pieralice
doaj   +1 more source

Serum sclerostin and bone turnover in latent autoimmune diabetes in adults [PDF]

, 2018
Bone formation is impaired in both type 1 and type 2 diabetes (T2D) while sclerostin, an antagonist of bone formation, is increased in T2D only. No data are available on latent autoimmune diabetes in adults (LADA), an autoimmune type of diabetes that may
D'Onofrio, L, Gaetano Leto, Buzzetti, Raffaella, Giuseppe Campagna, Campagna, G, R David Leslie, Hawa, Mohammed I, Napoli, Nicola, Mohammed I Hawa, Manfrini, Silvia, Strollo, R, Simona Zampetti, Leto, Gaetano, Greto, Valentina, Leslie, RD, Palermo, Andrea, Rocky Strollo, Valentina Greto, Silvia Manfrini, Moretti, Chiara, Zampetti, Simona, Moretti, C, Paolo Pozzilli, Napoli, N, Nicola Napoli, D'Onofrio, Luca, Defeudis, Giuseppe, Strollo, Rocky, Andrea Palermo, Raffaella Buzzetti, Leslie, R David, Luca D’Onofrio, Greto, V, Pozzilli, P, Buzzetti, R, Giuseppe Defeudis, Zampetti, S, Manfrini, S, Palermo, A, Chiara Moretti, Campagna, Giuseppe, Defeudis, G, null null, Pozzilli, Paolo, Leto, G, Hawa, MI   +45 more
core   +1 more source

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

The system of tumor necrosis factor α in the pathogenesis of autoimmune diabetes mellitus

Бюллетень сибирской медицины, 2011
The aim of this study was to evaluate the impact of TNFα and their receptor in autoimmune diabetes. It was found the most pronounced inhibition of production of soluble forms of the receptor for TNFα in the background of an increased number of ...
T. S. Prokhorenko, T. V. Saprina, F. E. Lazarenko, N. V. Ryazantseva, I. N. Vorozhtsova, V. V. Novitsky   +5 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Autoimmunity in latent autoimmune diabetes in adults

AIMS Medical Science, 2019
Latent autoimmune diabetes in adults (LADA) is clinically characterized by onset after age 30, absence of ketoacidosis, insulin independence for at least 6 months after diagnosis, and presence of circulating islet-cell antibodies. These include glutamic acid decarboxylase (GADA) autoantibodies, tyrosine phosphatase-2 autoantibodies, or zinc-transporter
openaire   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source