Results 51 to 60 of about 119,179,614 (214)

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Frequency of islet autoantibody seropositivity among adults with newly diagnosed type 2 diabetes in the Kazakh population: A cross‐sectional study

Journal of Diabetes Investigation
Aims/Introduction Type 2 diabetes mellitus (T2DM) is a heterogeneous condition, and a proportion of patients show autoimmune features consistent with latent autoimmune diabetes in adults (LADA).
Khatimya Kudabayeva, Bibigul Tleumagambetova, Yerlan Bazargaliyev, Lorina Vudu   +3 more
doaj   +1 more source

Latent autoimmune diabetes in adults phenotype with recurrent hypoglycemia as diagnostic challenge (case report)

Mìžnarodnij Endokrinologìčnij Žurnal
Latent autoimmune diabetes in adults (LADA) represents a hybrid form of diabetes characterized by autoimmune destruction of β-cells, clinical features of type 2 diabetes, and a slow progression to insulin dependence.
Teuta Mulla Goga, Afrim Zeqiraj
doaj   +1 more source

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

Advanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen, Shen Zhang, Yuli Zhu, Da Zhou, Chunya Ji, Mingrui Zhu, Sirui Wang, Yuting Shen, Jifeng Yu, Heng Zhang, Yan Fang, Huixiong Xu, Haohao Yin   +12 more
wiley   +1 more source

Latent Autoimmune Diabetes in Adults Differs Genetically From Classical Type 1 Diabetes Diagnosed After the Age of 35 Years

, 2010
OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years.
Turunen, Joni A., Lundgren, Virve, Per-Henrik Groop, Isomaa, Bo, Virve Lundgren, Forsblom, Carol, Leif Groop, Groop, Leif, Andersen, Mette K., Groop, Per-Henrik, Groop, Per Henrik, Carol Forsblom, Tiinamaija Tuomi, Bo Isomaa, Mette K. Andersen, Joni A. Turunen, Tuomi, Tiinamaija, Groop, Leif,, Lund University.   +18 more
core   +1 more source

Prevalence and Correlates of Latent Autoimmune Diabetes in Adults in Tianjin, China

, 2010
OBJECTIVE Data on latent autoimmune diabetes in adults (LADA) from population-based studies are sparse. We sought to investigate the prevalence and correlates of LADA.
Yun Xie, Qi, X, Jia, J, Jing Sun, Xie, Y, Wang, J, Jianhua Wang, Zhongliang Xu, Xiuying Qi, Peizhong Peter Wang, Wang, PP, Xie, Yun, Wang, Jianhua, Xu, Z, Xu, Zhongliang, Murphy, Madonna, Jia, Junting, Junting Jia, Xu, W,, Jing Wang, Wang, Jing, Wang, Peizhong Peter, Weili Xu, Sun, J, Madonna Murphy, Xu, Weili,, Murphy, M, Sun, Jing, Qi, Xiuying   +28 more
core   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Exogenous Insulin Injection-Induced Stiff-Person Syndrome in a Patient With Latent Autoimmune Diabetes: A Case Report and Literature Review

Frontiers in Endocrinology, 2020
Stiff-person syndrome (SPS) is highly associated with anti-glutamic acid decarboxylase (GAD) antibody. However, GAD antibodies alone appear to be insufficient to cause SPS, and they possibly are involved in only part of its pathophysiology.
Yi-Yin Lee, Cheng-Wei Lin, I-Wen Chen
doaj   +1 more source

Fecal microbiota transplantation and microbiota‐based therapeutics in pediatric clinical practice: Current status and emerging indications

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Fecal microbiota transplantation (FMT) is a safe and effective treatment for recurrent or refractory Clostridioides difficile infection (rCDI) in children and adults. This review outlines the evidence behind FMT for rCDI, considerations in special pediatric populations, and limitations in current practice due to FMT access for patients under ...
Nikhil Pai, Maribeth Nicholson, Steven Rich, Máire A. Conrad   +3 more
wiley   +1 more source

Subcorneal Pustular Dermatosis, a Systematic Review and Pooled Analysis of a Rare and Underdiagnosed Disease

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Subcorneal pustular dermatosis (SPD), or Sneddon–Wilkinson disease, is a rare, relapsing pustular skin condition of unknown cause, characterised by subcorneal pustules. Objectives To summarise the demographic, clinical, histopathological, management and disease course of SPD.
Mason H. Crossman, Jeffrey Weng, Alysha Vuong, Lawrence Lin, Zhao Feng Liu, Christopher Y. Chew   +5 more
wiley   +1 more source