Results 61 to 70 of about 119,179,614 (214)

Insulin Autoimmune Syndrome as Part of Pre-Clinical LADA

Diabetes, Metabolic Syndrome and Obesity, 2021
Edyta Sutkowska,1 Malgorzata Ostrowska,2 Magdalena Sutkowska3 1Medical Division, Department and Division of Medical Rehabilitation, Wroclaw Medical University, Wroclaw, Poland; 2Clinical Department of Nephrology and Dialysis Station, Karol Marcinkowski ...
Sutkowska E, Ostrowska M, Sutkowska M
doaj  

Time-varying risk of microvascular complications in latent autoimmune diabetes of adulthood compared with type 2 diabetes in adults: a post-hoc analysis of the UK Prospective Diabetes Study 30-year follow-up data (UKPDS 86)

, 2020
Background: Latent autoimmune diabetes of adulthood (LADA) differs in clinical features from type 2 diabetes. Whether this difference translates into different risks of complications remains controversial.
Maddaloni E., Coleman R. L., Holman R. R., Buzzetti R., Agbaje O.   +4 more
core   +1 more source

Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]

, 2010
OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.
Ruaidhri J. Carmody, Shi-Jun Zheng, Scott Palmer, Palmer, S., Ruan, Q., Chen, Y.H., Carmody, R.J., Youhai H. Chen, Zheng, S.-J., Qingguo Ruan   +9 more
core   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes

, 2021
Latent autoimmune diabetes of adults (LADA) is typically defined as a new diabetes diagnosis after 35 years of age, presenting with clinical features of type 2 diabetes, in whom a type 1 diabetes–associated islet autoantibody is detected.
Hagopian, William, Hattersley, Andrew T., Jones, Angus G., Shields, Beverley M., McDonald, Timothy J., William Hagopian, Timothy J. McDonald, Angus G. Jones, Beverley M. Shields, Andrew T. Hattersley   +9 more
core   +1 more source

Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records

Movement Disorders, EarlyView.
Abstract Background Ursodeoxycholic acid (UDCA) has shown mitochondrial and neuroprotective effects and has been proposed as a treatment for Parkinson's disease (PD). However, population‐level evidence on its effect on PD risk is lacking. Objectives To compare the risk of incident PD among UDCA initiators versus matched non‐initiators within a ...
Chengsheng Ju, Anette Schrag, Camille Carroll, Xi Xiong, James Carpenter, Oliver Bandmann, Thomas Foltynie, Li Wei   +7 more
wiley   +1 more source

Adult-onset autoimmune diabetes: comparative analysis of classical and latent presentation

Diabetology & Metabolic Syndrome, 2020
Introduction Adult-onset autoimmune diabetes (AID) has two different phenotypes: classic type 1 diabetes mellitus (T1DM), with insulin requirement just after diagnosis, and latent autoimmune diabetes in adults (LADA).
Lúcia Fadiga, Joana Saraiva, Diana Catarino, João Frade, Miguel Melo, Isabel Paiva   +5 more
doaj   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

The role of Th1/Th2 disbalanced immune response in the determination of clinical features of autoimmune diabetes mellitus

Сахарный диабет, 2011
Aim. To elucidate the role of Th1/Th2 polarization of immune response in LADA patients in the realization of the clinical phenotype of the disease. Materials and methods. 70 patients aged 21-61 (mean 41.3?1.0 yr) with DM diagnosed based on WHO criteria
Tatiana Vladimirovna Saprina, F E Lazarenko, T S Prokhorenko, N V Ryazantseva, Irina Nikolaevna Vorozhtsova   +4 more
doaj   +1 more source

High Levels of Education Are Associated With an Increased Risk of Latent Autoimmune Diabetes in Adults

, 2010
OBJECTIVE To investigate whether the risk for autoimmune diabetes in adults differs between socioeconomic groups and to compare such risk with that for type 2 diabetes.
Lisa Olsson, Anders Ahlbom, Valdemar Grill, Ahlbom, A,, Kristian Midthjell, Olsson, L,, Midthjell, K, Grill, V, Sofia Carlsson, Carlsson, S   +9 more
core   +1 more source