Results 61 to 70 of about 7,475 (211)

Subgroups of Adult‐Onset Diabetes: A Prospective Follow‐Up Study of Progression of Insulin Resistance and Deficiency and Association With Liver Steatosis and Fibrosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess progression of insulin deficiency and resistance in diabetes, the stability of cluster‐based subgrouping, and the association between steatotic liver disease (SLD), liver fibrosis (LF), and tissue insulin resistance. Materials and Methods Participants from a regional diabetes register were studied within 3 years from diagnosis ...
Aleksi Laitinen, Annemari Käräjämäki, Aki J. Käräjämäki, Samu Kurki, Liisa Hakaste, Olof Asplund, Johan Hultman, Kaj Lahti, Mikko Lehtovirta, Emma Ahlqvist, Tiinamaija Tuomi   +10 more
wiley   +1 more source

Latent autoimmune diabetes in adults: current data (review of literature and own data)

Mìžnarodnij Endokrinologìčnij Žurnal
The article provides up-to-date information on latent autoimmune diabetes in adults (LADA), presents data on epidemiology, factors and mechanisms of development, clinical features of this disease.
N.V. Pashkovska, I.O. Tsaryk
doaj   +1 more source

Dupilumab as an Effective Adjuvant Therapy for Corticosteroid‐Refractory Lichenoid‐Bullous Dermatitis Secondary to Pembrolizumab

Australasian Journal of Dermatology, EarlyView.
Brandon Tan, Gaurav N. Pathak, Alexis Lara Rivero   +2 more
wiley   +1 more source

Impact of Autoimmune Hypothyroidism and Celiac Disease on Progression to Diabetes in Individuals Positive for GAD65 or IA‐2 Autoantibodies

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether autoimmune hypothyroidism (AH) or celiac disease (CD) influences diabetes progression among individuals who tested positive on a pooled screening assay for glutamic acid decarboxylase 65 and insulinoma‐associated protein 2 autoantibodies (GADA/IA‐2A).
Afif Nakhleh, Gil Beeri, Omer Sudri, Shay Rotkopf, Naim Shehadeh   +4 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Latent autoimmune diabetes in youth

Frontiers in Immunology
Latent autoimmune diabetes in youth (LADY) is an emerging and under-recognized subtype of autoimmune diabetes, occurring in young individuals who present with clinical features overlapping both type 1 and type 2 diabetes.
Qingxia Sun, Qingxia Sun, Min Yang, Yiheng Jing, Lingzhe Meng, Chang Zhang, Jie Ruan, Na Wu   +7 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series

Diabetes, Metabolic Syndrome and Obesity, 2021
Song Wen, Wenjing Jiang, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan ...
Wen S, Jiang W, Zhou L
doaj